Navigation Links
Adiponectin shows potential in blocking obesity-related carcinogenesis
Date:10/19/2010

A research team from Emory University School of Medicine investigated the role between adiponectin and leptin in obesity-related carcinogenesis. Their findings, published in the November issue of Hepatology, suggest that the protein hormone adiponectin has potential for inhibiting the oncogenic actions of leptin, namely in hepatocellular carcinoma (HCC), and could offer a promising therapy for the disease.

Obesity is on the rise and is associated with increased risk and progression of a number of cancers including colon, prostate, breast, and liver cancers. The World Health Organization declared obesity one of the greatest public health challenges of the 21st century and projects that by 2015, more than 700 million adults will be obese. In the U.S., the Centers for Disease Control and Prevention (CDC) estimates roughly 72.5 million adults are considered obesehaving a body mass index (BMI) greater than 30.

Obese populations have higher circulating levels of leptin, the protein hormone that controls appetite, but lower concentrations of adiponectin which regulates glucose levels and the breakdown of fatty acids. Understanding the these hormones play a role in obesity-related cancers and the vast number of individuals who are at risk, Neeraj K. Saxena, Ph.D. and colleagues investigated the protective effect of adiponectin and its impact on leptin in HCC.

"Our study presents important clinical implications since HCC has the highest increased risk associated with obesity compared to other cancers such as prostate, kidney, colon, and stomach," commented Dr. Saxena. Using human cell-lines, mice models of HCC, and tissue microarray researchers determined the antagonistic role of adiponectin on the cancer-causing actions of leptin.

The authors found that adiponectin treatment inhibited leptin-induced proliferation, invasion, and migration of HCC cells. Treatment with adiponectin also slowed leptin-induced HCC tumor growth in vivo. Further analysis showed that leptin expression correlated positively with HCC proliferation and nonalcoholic steatohepatitis (NASH). Adiponectin expression had an inverse correlation with tumor size, and a direct correlation to disease-free survival in human HCC tumor samples.

"Taken together our results suggest an attractive molecular strategy employing adiponectin analogues for potential therapy of metastatic HCC," concluded Dr. Saxena. "With the prevalence of obesity in the U.S., our study could significantly improve overall survival for a vast number of obese liver cancer patients by using adiponectin to inhibit growth, invasion, and migration of HCC cells."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. First blinded study of venous insufficiency prevalence in MS shows promising results
2. People with anxiety disorder less able to regulate response to negative emotions, study shows
3. Poll Shows Eroding Support for Health Reform
4. Protecting patients: Study shows that Johns Hopkins flu vaccination rates twice national average
5. Compound shows promise against intractable heart failure
6. Drama or reality TV: Do medical shows depict proper first aid for seizures?
7. TV Shows Often Botch Proper Seizure Responses
8. UQ research shows canecutters disease on the rise among travelers
9. Brain Scan Shows What Beauty is Worth
10. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
11. New research shows emotional impact of low sexual desire and associated distress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... Harrisburg, PA (PRWEB) , ... May 04, 2016 , ... ... Commonwealth recently convened in the state capitol for the annual “Hike to Harrisburg” advocacy ... Society (PATS) and The Winter Group, PATS lobby Group. The goal for the ...
(Date:5/3/2016)... (PRWEB) , ... May 04, 2016 , ... ... than 40 national and global construction firms representing the Construction Industry Safety Initiative ... joined forces with one purpose: to inspire everyone in the industry to be ...
(Date:5/3/2016)... ... May 03, 2016 , ... In April, Amerec launched a new website ... help find the best steam and sauna solutions. , First, the Amerec website has ... improvement brings all of the site’s features, especially the Steam Builder Tool , ...
(Date:5/3/2016)... Irvine, California (PRWEB) , ... May 03, 2016 ... ... of its innovative brainsalvation tool – a web application that helps people assess ... medical research, the brainsalvation™ web app will provide users a “Risk Reduction Score™” ...
(Date:5/3/2016)... NJ (PRWEB) , ... May 03, 2016 , ... ... BCBSNJ) today announced that it has been honored as one of the nation’s ... the 2016 InformationWeek Elite 100. Horizon received the recognition for technology achievements that ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... YORK , May 3, 2016 ... (MRI) Market Size, Share, Development, Growth and Demand Forecast ... Open), by Field Strength (High Field, Very High Field, ... Application (Brain, Head and Neck, Spine, Musculoskeletal, Vascular, Breast, ... the global magnetic resonance imaging (MRI) market was valued ...
(Date:5/3/2016)... 3, 2016 Global and ... a basic overview of the industry that covers ... surgical mesh report explores into the international and ... report on Surgical Mesh market spread across 150 ... and figures is available at http://www.reportsnreports.com/reports/470569-global-and-chinese-surgical-mesh-industry-2016-market-research-report.html ...
(Date:5/2/2016)... 2016  Deerfield announced today it led the ... Inc. Graybug Vision is an early stage pharmaceutical ... care for ocular diseases including wet age-related macular ... first developed at Johns Hopkins University and has ... Graybug Vision is developing ophthalmology products ...
Breaking Medicine Technology: