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Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
Date:6/23/2009

ide. The transduction specificity of the ablated retargeted vector towards human pancreatic cancer cells was enhanced almost 10-fold in vitro. In a subsequent in vivo study of a nude (nu/nu ) mouse model however, no increased adenoviral targeting to subcutaneously growing human pancreas cancer nodules was seen upon injection into the tail vein, nor upon injection into the peritoneum.

Although re-directing of the adenoviral vector has been reported, this is the first paper showing effective uptake of adenoviral vector by the EphA2R that is present on solid tumors.


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Contact: Lai-Fu Li
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World Journal of Gastroenterology
Source:Eurekalert

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