Navigation Links
Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
Date:6/23/2009

Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. However, clinical studies have demonstrated poor efficacy of adenoviral gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as the coxsackie and adenovirus receptor (CAR). Circumventing CAR-mediated entry therefore seems a promising option to improve adenoviral entry into pancreatic cancer cells and to enhance the efficacy of adenoviral vectors.

A research team led by Dr. Piter J Bosma from University of Amsterdam addressed this question. Their study will be published on June 14, 2009 in the World Journal of Gastroenterology.

They present a novel adenoviral vector that binds to the EphA2 receptor (EphA2R). This receptor is highly expressed in several solid tumors including pancreatic cancer. YSA, a small peptide ligand that binds the EphA2R with high affinity, was inserted into the HI loop of the adenovirus serotype 5 fiber knob. To further increase the specificity of this vector, binding sites for native adenoviral receptors, the coxsackie and adenovirus receptor (CAR) and integrin, were ablated from the viral capsid. The ablated retargeted adenoviral vector was produced on 293T cells. Specific targeting of this novel adenoviral vector to pancreatic cancer was investigated on established human pancreatic cancer cell lines. Upon demonstrating specific in vitro targeting, in vivo targeting to subcutaneous growing human pancreatic cancer was tested by intravenous and intraperitoneal administration of the ablated adenoviral vector.

They found that ablation of native cellular binding sites reduced adenoviral transduction at least 100-fold. Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor. YSA-mediated transduction was inhibited by addition of synthetic YSA pept
'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. American Medical Association Clears Path for Adenoviral Conjunctivitis - Pink Eye - Detector
2. State Legislature Declares April 21 to 25, 2008 West Nile Virus and Mosquito and Vector Control Awareness Week
3. Non-Profit Healthcare Facilities Invited to Submit Essays in Vector180s Worthy Of Wi-Fi Contest
4. Vaporized viral vector shows promise in anti-cancer gene therapy
5. EaglePicher Technologies Introduces First Implantable Medical Cell Designed Specifically for Monitoring Applications
6. eDiets(R) Partners with alli(R) to Launch Specifically Designed Fresh Meal Delivery Program
7. Paro, the Worlds Only Robotic Baby Harp Seal - Designed Specifically for Therapy - to be Focus of Industry Event at Vinson Hall Retirement Community in McLean, Va., June 2
8. leViv Launches First Meal Programs Specifically Designed for Taste and Health
9. The First Treatment Specifically Approved for Huntingtons Disease Patients is Now Available in the United States
10. Video: Schering-Plough Introduces TINACTIN(R) CHILL, a Line of Antifungal Products Geared Specifically to Young Males
11. First and Only Weaning Product Based on 100% Non-Allergenic Amino-Acids Specifically Designed for Children With Cows Milk Protein Allergy and Multiple Food Protein Intolerance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , ... August 01, 2015 , ... The Honor Society ... Advisory Panel on the Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, ... participate in this meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted by Becker’s ... predictive health analytics , Jvion continues to disrupt the predictive analytic and big ... targets patient and population level illness to drive prevention and better health outcomes. ...
(Date:7/31/2015)... ... , ... There’s no better way to enjoy the summer weather than by ... next meal, making July the most appropriate to be National Hot Dog Month. King ... Make the next cookout different than the ones in the past. Celebrate National Hot ...
(Date:7/31/2015)... ... 31, 2015 , ... M3 USA MDLinx.com, source of the Smartest Doc Board ... Courses. , The additions of Gastroenterology, Pulmonology and Allergy/Immunology round out an already ... for the exam easy and painless. MDLinx offers thousands of board-exam style questions ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Well-known for ... now offering wedding cakes with custom designs, making life just a little ... beautifully designed wedding cakes for each customer who orders one. , The bakery provides ...
Breaking Medicine News(10 mins):Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2
... mimic sounds and now researchers have used ,virtual mates, to ... on a mate. The research, published in Ethology , ... ,calls,. Parrots are among the few species of ... mimic new sounds, but the evolutionary reason for this ability ...
... a single rock being overturned or an entire mountaintop ... processes, and vice versa. Ecological scientists will discuss findings ... growth to the diversity of insect species on green ... buildingsat the Ecological Society of America,s 95th Annual Meeting ...
... tools for simultaneous tumor imaging and treatment, because of ... cells. In mice, researchers from Emory University School of ... to implanted brain tumors, while enhancing tumor visibility via ... online by the journal Cancer Research . ...
... Reinberg HealthDay Reporter , MONDAY, Aug. 2 ... time on the Internet run the risk of developing ... 1990s, uncontrolled or unreasonable Internet use has been identified ... researchers say. Pathological Internet use has been linked with ...
... Dotinga HealthDay Reporter , MONDAY, Aug. 2 (HealthDay ... partly inherited, a new study reveals that close relatives of ... are much more likely than those of other people to ... families with autism," said study co-author John A. Sweeney. "These ...
... symbol of courage and sacrifice, of sin and sexuality, of ... the color red makes men more alluring to women. ... found men more appealing when they were either pictured wearing ... finding is reported in the August issue of the ...
Cached Medicine News:Health News:'Virtual mates' reveal role of romance in parrot calls 2Health News:Scientists unravel human-ecosystem interactions 2Health News:Scientists unravel human-ecosystem interactions 3Health News:Scientists unravel human-ecosystem interactions 4Health News:Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment 2Health News: Addictive Internet Use Tied to Depression in Teens 2Health News: Addictive Internet Use Tied to Depression in Teens 3Health News:Vision Abnormality Seen in Close Relatives of Autism Patients 2Health News:Women more attracted to men in red 2
(Date:7/30/2015)... Calif. , July 30, 2015 Edwards Lifesciences ... science of heart valves and hemodynamic monitoring, today announced that ... Board of Directors. "Bob is an ardent champion ... a true privilege to have him on Edwards, board as ... Mussallem , Edwards, chairman and CEO.  "Bob has provided a ...
(Date:7/30/2015)... 2015  ResMed Inc. (NYSE: RMD ) today ...  Revenue for the quarter was $453.1 million, a 9 ... 2014 (a 17 percent increase on a constant currency ... quarter ended June 30, 2014.  Diluted earnings per share ... ended June 30, 2014.  The results ...
(Date:7/30/2015)...  Unichem Pharmaceuticals ( USA ), Inc. ... 25 mg 1000-count bottle to the consumer level. This ... to the identification of a Clopidogrel tablet found in ... risk associated with mistakenly taking a Clopidogrel tablet instead ... experiencing Clopidogrel,s side effects which include bleeding and/or bruising. ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
... from the "NEXT" Study Also Showed Arzoxifene Significantly ... Women with OsteoporosisATHENS, Greece, March 23 Eli ... presented new data showing arzoxifene, an investigational selective ... at increasing bone mineral density (BMD) in the ...
... TBI TrialCOSTA MESA, Calif., March 19 Oxygen Biotherapeutics, ... company has received a letter from the FDA that ... a basis to resume clinical studies of Oxycyte(R) in ... carrier.The letter was in response to the company,s request ...
Cached Medicine Technology:Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 2Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 3Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 4Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 5Oxygen Biotherapeutics, Inc. Receives Letter From FDA Outlining Path Forward to Resume Oxycyte Clinical Trials in TBI in U.S.A. 2Oxygen Biotherapeutics, Inc. Receives Letter From FDA Outlining Path Forward to Resume Oxycyte Clinical Trials in TBI in U.S.A. 3
For vacuum-driven processing of spin columns; Reduced sample handling and accelerated processing; Parallel sample processing using QIAGEN spin columns; Easy cleaning of internal components by simpl...
Inquire...
... allows processing of up to 24 spin columns in ... columns into and out of a centrifuge. The ... savings rapid vacuum-driven purification and cleanup of ... Convenience minimal hands-on-time ...
... Caliper provide an automated alternative to Kuderna-Danish, Rotary, Vacuum-Style and Nitrogen Blow-Down Evaporators. For over ten years ... ... ... ...
Medicine Products: