Navigation Links
Additional Steroid Dose May Help Preemies
Date:1/29/2009

Fewer babies have complications, without ill effects, study finds

THURSDAY, Jan. 29 (HealthDay News) -- Giving a second dose of steroids to babies still in the womb can reduce their post-birth respiratory problems and does not seem to affect their growth the way multiple courses can, new research shows.

In babies born before 34 weeks, about 43 percent of those given a second dose of steroids in utero had complications, compared with about 63 percent of the babies given a placebo.

"We saw a 31 percent reduction in overall composite neonatal morbidity. That's highly significant," said study author Dr. James Kurtzman, an associate clinical professor in the division of maternal-fetal medicine in the department of obstetrics and gynecology at the University of California, Irvine.

The real advantage, he added, came from the reduction in respiratory problems. Fewer babies had respiratory distress syndrome, and fewer babies needed mechanical ventilation.

Results of the study were to be presented Jan. 29 at the Society for Maternal-Fetal Medicine's annual meeting in Washington, D.C. The study will also be published in the March edition of the American Journal of Obstetrics and Gynecology.

Kurtzman and his colleague, Dr. Thomas Garite, began the study because they were concerned that some premature babies were missing out on the potential benefits from at least one dose of pre-birth steroids.

When doctors first started giving steroids to mothers who appeared to be going into pre-term labor, they discovered that, for the babies' health, it was best if the steroid dose was given no more than seven days before delivery.

But it's not always easy to tell exactly when a woman will deliver. So, if a woman passed the seven-day mark and still had not delivered, doctors would repeat the steroid dose. However, doctors soon learned that multiple courses of steroids led to growth restriction and smaller head circumferences in the babies.

"Then the pendulum swung the other way, and doctors were holding out on giving the first dose" until they were sure the woman was going to deliver, Kurtzman explained. That resulted in some women never getting treated before delivery.

"So, we developed this study for patients that remained pregnant for more than two weeks after receiving their first course," he said.

The study included 437 women from 18 medical facilities -- both community hospitals and academic medical centers. The women were randomly assigned to receive either a second, so-called "rescue," dose of steroids closer to delivery or a placebo.

The researchers found a significant reduction in respiratory problems for babies who received the second dose of steroids. Plus, they found no evidence of growth restriction or smaller head circumferences.

"We try to do the best we can to predict who's going to deliver early, but it's not always possible," Kurtzman said. "This information allows us to be a little bit less concerned about the timing of the first course, and that has a tremendously positive impact."

Dr. Peter Bernstein, a maternal-fetal medicine specialist at Montefiore Medical Center in New York City, said that premature birth is "one of our top problems" in obstetrics. "It's the second leading cause of neonatal mortality in the U.S.," he said. "This study shows we're continuing to chip away at this problem, and we're doing better."

More information

The March of Dimes has advice for expectant moms on preventing premature birth.



SOURCES: James Kurtzman, M.D., associate clinical professor, division of maternal-fetal medicine, department of obstetrics and gynecology, University of California, Irvine, and maternal-fetal medicine attending and former obstetrics chief, Saddleback Women's Hospital, Laguna Hills, Calif.; Peter Bernstein, M.D., maternal-fetal medicine specialist, Montefiore Medical Center, and associate professor, obstetrics and gynecology, and women's health, Albert Einstein College of Medicine, New York City; Jan. 29, 2009, presentation, Society for Maternal-Fetal Medicine annual meeting, Washington D.C.


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. USAID Provides Additional Wildfire Assistance to Greece
2. Creative Technology Services Enhances its Global Competitiveness with Additional Regulatory Certifications
3. Additional Top Tier Institutions Implement Mediwares HCLL(TM) Transfusion Management Software
4. Whole Foods Market(R) Donates $25,000, for Midwest Farmers - Hoping to Match an Additional $10,000, via Customer Donations
5. Virginia Techs Raving First Year Results Lead to Additional High-Tech Antimicrobial Defense from SportCoatings(TM)
6. People With Chronic Conditions Experience Additional Benefits of Cost Savings by Wearing a Medical ID
7. Using additional biopsy-scoring data may help determine prostate cancer prognosis
8. Castle Connolly Medical Ltd. Partners with DrScore.com to Provide Additional Quality Information About Doctors to Consumers
9. Dynatronics Adds Three Additional Direct Sales Reps
10. ReBuilder Medical Technologies, Inc. Announces Agreement with Internet Marketer Helio Health; Anticipates 12% Additional Profit
11. Aida Granted Additional Anti-Cancer Patent
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Additional Steroid Dose May Help Preemies
(Date:2/8/2016)... ... 2016 , ... FileHold's document management software has been implemented ... hosted environment for FileHold software that is pay per user subscription-based and also ... the FileHold web services API. DocuSyst also advises clients on fully functioning back ...
(Date:2/8/2016)... ... February 08, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... are derived from a cluster of melanin when exposed to sunlight. Although most moles ... a lifetime of embarrassment. Historically, mole removal has involved a painful, often ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... (NADL), only four states in the U.S. require dental technicians to be certified ... in the dental industry, NADL created the “What’s In Your Mouth?” campaign to ...
(Date:2/7/2016)... ... February 07, 2016 , ... ... has added Kybella® to his medical and surgical expertise. Technically known as deoxycholic ... injectable medication used as a non-surgical alternative for reduction of fat below the ...
(Date:2/6/2016)... ... February 06, 2016 , ... Shark Finds and ... launch of a new DRTV campaign with Belly Bands. , Having a dog is ... sprays to puppy pads and find nothing works, get Belly Bands, the easiest ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  As people age, ... The multitude of recommended screenings and tests that are ... a priority. However, for the majority of aging individuals, ... health planning. For the 37.5 million American adults who ... the present to make hearing health a 2016 healthy ...
(Date:2/5/2016)... , Feb. 5, 2016  Aralez Pharmaceuticals Inc. ("Aralez") ... POZEN Inc. ("POZEN") and Tribute Pharmaceuticals Canada Inc. ("Tribute") following ... shareholders of Tribute. The combined company will operate under ... with operations in Canada , ... States . Under the terms of the Agreement ...
(Date:2/5/2016)... , Feb. 5, 2016 Aethlon Medical, Inc. (Nasdaq: ... Chairman and CEO, will be presenting at Source Capital Group,s ... York, NY at 2:15 p.m. ET on Wednesday, ... Immunotherapy Panel discussion taking place at 3:15 p.m. ET. ... approximately one hour after the conclusion of the live event. ...
Breaking Medicine Technology: