Navigation Links
Adding ipilimumab to standard chemotherapy treatment for late-stage lung cancer may improve survival
Date:12/9/2010

Ipilimumab used in combination with paclitaxel/carboplatin for stage IIIb/IV non-small cell lung cancer showed superior results in progression free survival when compared to paclitaxel/carboplatin alone, according to research presented at the 2010 Chicago Multidisciplinary Symposium in Thoracic Oncology. This symposium is sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO), the International Association for the Study of Lung Cancer (ISLAC) and the University of Chicago.

Paclitaxel/carboplatin are commonly used chemotherapy drugs in lung cancer patients. Ipilimumab is a human monoclonal antibody that is used to activate the immune system. It works by blinding to and blocking the activity of CTLA-4, a molecule on T-cells that is thought to play a large role in regulating natural immune responses, which as a result sustains an active immune response when attacking cancer cells.

Researchers in this randomized phase II trial sought to determine if adding ipilimumab to treatments for stage IIIb/IV lung cancer patients would impact overall survival and progression free survival. Over 200 patients were treated using ipilimumab plus a concurrent schedule of paclitaxel/carboplatin, ipilimumab plus a phased schedule of paclitaxel/carboplatin or paclitaxel/carboplatin alone.

With both schedules, using ipilimumab in combination with paclitaxel/carboplatin showed improved progression free survival rates when compared to paclitaxel/carboplatin alone. The phased schedule did show better efficacy than the concurrent schedule, but in no instance did ipilimumab increase paclitaxel/carboplatin related toxicity.

"Phase III and IV lung cancers do not often see positive end results, so there is a lot of room to improve treatments for this disease," Thomas Lynch, M.D., lead author of the study, a professor of medicine at Yale University in New Haven, Conn., and director of the Yale Cancer Center, said. "Ipilimumab is one of the few immunotherapies that have shown positive results in treating lung cancers, and if adding this to standard treatments can improve survival, then it is worth further trials."


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-431-2332
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Alzheimers Association Applauds Social Security Administration for Adding Early-Onset Alzheimers to Its Compassionate Allowances Initiative
2. Adding Surgery to Meds May Improve Life With Parkinsons
3. Ellsworth Adhesives Is Adding PRC Rapid Seal Product Line Offering
4. Adding Recess to the Workday Gains Backers
5. Adding topotecan to standard treatment for ovarian cancer does not improve progression-free survival
6. Adding radiation to hormone therapy for prostate cancer treatment will increase survival chances
7. Adding Monounsaturated Fats to Diet May Boost Heart Health
8. Adding monounsaturated fats to a low-cholesterol diet can further improve levels
9. Adding pharmacists to docs offices helps patient outcomes, study shows
10. Adding Surgery to Meds May Help Diabetics With Heart Disease
11. One-third of antimalarial medicines sampled in 3 African nations found to be substandard
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Coast Dental ... February is National Children’s Dental Health Month and family dentist Yvonne Dorrian, DMD, is ... at Coast Dental , located next to Target at 1207 North Peachtree Parkway ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... BantamPro L top-load case packer for pouches, bags, and flow wrapped products at ... help co-packers and specialty product manufacturers step up to semi-automatic or fully-automatic case ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... metro area, has selected the latest beneficiary of their ongoing community enrichment program. ... preventing bullying in area schools. Donations are now being accepted at: http://www.angelsanddoves.com/donate.html ...
(Date:2/8/2016)... ... ... Remember the old saying “rub some dirt on it”? Perhaps you should ... Bentonite Clay” the health benefits of integrating clay into a daily diet are numerous, ... former motivational speaker, Perry A~ has since dedicated her life to learning about the ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... greater than 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth ... ”It is time to make a change in public health,” states Carole Baggerly, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... COLUMBUS, Ohio , Feb. 8, 2016 /PRNewswire/ ... to introduce the PW Series Solvent Recycling Systems, ... series offers full integration with new and existing ... This integration produces consistently-fresh solvent through continuous recycling ... --> --> ...
(Date:2/8/2016)... , Feb. 8, 2016  Ventana Medical Systems, ... hundreds of the world,s top oncologists, pathologists, research ... the 12 th annual Tucson Symposium March ... theories and new outcomes in cancer research and ... lives. Thomas Grogan , annually draws ...
(Date:2/8/2016)... --  GS1 US will hold a series of ... Standards implementation to address the requirements of the U.S. ... rule. Scott Brown , director of ... director industry development, medical devices, GS1 US; and ... --> Scott Brown , director of ...
Breaking Medicine Technology: