Navigation Links
Adding Chemo Helps Head, Neck Cancer Patients
Date:10/27/2009

Study found it doubled survival time

TUESDAY, Oct. 27 (HealthDay News) -- Combining chemotherapy with radiation treatment for patients with advanced head and neck cancer increases their event-free survival to 2.2 years from just one year with radiotherapy alone, finds a new study.

According to the study authors, "events" include cancer recurrence, new tumors or death.

British researchers looked at the 10-year outcomes of 966 patients with locally advanced head and neck cancer. Those who hadn't undergone surgery for their cancer were randomly assigned to one of four groups: radiotherapy alone (233 patients); two courses of simultaneous (SIM) chemotherapy given at the same time as radiotherapy (166 patients); two courses of chemotherapy after (subsequent -- SUB) completing radiotherapy (160 patients); or both SIM and SUB (154 patients). Patients who'd had surgery were randomly assigned to radiotherapy alone (135 patients) or SIM alone (118 patients).

Overall, non-platinum-based chemotherapy given at the same time as radiotherapy reduced deaths and cancer recurrence in patients who hadn't undergone surgery, with acceptable toxicity. But patients who'd undergone surgery didn't benefit from this combined treatment. The researchers also found that chemotherapy given after radiotherapy was ineffective, didn't improve survival, and doubled the rate of toxicity.

Among patients who didn't have surgery, median survival time was 2.6 years in the radiotherapy group, and 4.7 years, 2.3 years and 2.7 years, respectively, in patients who received SIM alone, SUB alone, and SIM plus SUB.

Median event-free survival among patients who didn't have surgery was one year in the radiotherapy group, 2.2 years in patients who received SIM alone, and one year in those who received either SUB alone, or SIM plus SUB.

The findings show the long-term benefit of non-platinum chemotherapy drugs, which are "inexpensive, relatively easy to deliver, and have lower toxicity than platinum therapies ... [which] considerably improves the likelihood of completing treatment, essential for improving the chances of a cure," wrote the U.K. Head and Neck Cancer Group researchers in their report published in the Oct. 27 online edition of The Lancet Oncology.

Combination chemotherapy/radiation treatment should be standard for all advanced head and neck cancer patients for whom surgery isn't appropriate, they concluded.

More information

The U.S. National Cancer Institute has more about head and neck cancer.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, Oct. 27, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Adding tools against breast tumors
2. Adding Drug Doesnt Help Control Blood Pressure
3. CutisPharma Launches New Prescription Mouthwash Kit Adding to Product Line
4. Adding a Stent May Help Resolve Brain Aneurysm
5. Dakim BrainFitness Now Used in 286 Senior Living Communities, Adding 136 Sites in 12 Months for Dementia-Fighting System
6. Hospital Improves Patient Experience by Adding Email and Web Access in Patient Rooms With Virtual Linux Desktops
7. Contracts adding legal twist to family health care
8. Takeda to Acquire IDM Pharma, Adding MEPACT(R) (Mifamurtide), the First Treatment Approved for Osteosarcoma in More Than 20 Years, to Its Oncology Franchise
9. CoolSign 4.3 Released Adding New Features for Digital Signage Networks
10. Syndication Inc. Seeks Director of Marketing for Sy-Med Decompression Centers; BOD Considers Adding a Green Energy New Company Subsidiary to its Ranks
11. Adding a Cancer Drug May Make Matters Worse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... The CFOs included on ... health systems in the nation and help their organizations navigate the challenges in ... been instrumental in developing successful hospital and health system strategy. , Becker's Hospital ...
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – with a ... lifting weights for strength training and exercise or simply lifting heavy objects, advises Dr. ... position is everything,” Dr. Chang says. “Improper technique in lifting anything heavy or an ...
(Date:5/23/2017)... ... 23, 2017 , ... MDLand International (MDLand), a leading Electronic ... its iClinic V12.2 solution has achieved approval from National Center for Quality Assurance ... standards which emphasize team-based care with a significant focus on the care management ...
(Date:5/23/2017)... ... ... Allegheny Health Network and the Alexis Joy D’Achille Foundation ... at West Penn Hospital , a unique facility that will offer the most ... Construction of the Center is underway with a scheduled opening in the fall of ...
(Date:5/23/2017)... ... 23, 2017 , ... Cambridge, MA, May 23, 2017—Total costs ... to a Workers Compensation Research Institute (WCRI) study, a contrast from the increases ... CompScope™ Benchmarks, 17th Edition looks at indemnity and medical payments for workers’ ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
(Date:5/3/2017)... 2017  Kalorama Information notes that transplant diagnostics ... year and this is projected to continue to ... (HSCT) or bone marrow transplants require histocompatibility between ... for this task. This according to a new ... The various PCR-based methodologies, Sanger sequencing and NGS ...
(Date:5/2/2017)... YORK and LONDON , ... of market intelligence, MarketResearch.com is pleased to announce a ... AB that allows for the marketing and distribution ... analyses through the MarketResearch.com website. The new ... to complete product descriptions and tables of contents from ...
Breaking Medicine Technology: