Navigation Links
Addex highlights strength of allosteric modulation technology platform

Geneva, Switzerland, 12 November 2010 Allosteric modulation company Addex Pharmaceuticals (SIX:ADXN) announced today that data on a total of nine therapeutic programs will be presented during Society for Neuroscience 2010 (November 13-17, San Diego, USA), highlighting the strength of its allosteric modulation technology platform. The data being presented cover multiple receptor types and therapeutic areas, including Parkinson's disease, schizophrenia, anxiety, Alzheimer's disease and depression.

"The data generated by Addex and our partners, Ortho-McNeil-Janssen and Merck & Co., being presented at the Society for Neuroscience 2010 conference illustrate the power of our allosteric modulation product generating engine. Although the targets we are addressing have been pursued for many years with standard discovery technologies, most have proven elusive," explained Dr. Vincent Mutel, CEO of Addex. "Our technology is allowing us to bring a new kind of chemistry to industrial drug discovery efforts and thereby improve discovery productivity, a key bottleneck hindering the pharmaceutical industry. Beyond our presentations at Society for Neuroscience this year, we have recently demonstrated our ability to expand our discovery technology beyond GPCRs, like glutamate receptors, to cover other types of cell surface receptors, such as cytokine receptors, including TNF receptors. In addition to advancing our own molecules, we will look to sign multiple collaborative partnerships to realize the potential of our platform."

Small molecule allosteric modulators represent an unexploited kind of chemistry which is different from the traditional small molecule drugs. Orally available allosteric modulators can offer multiple competitive advantages over classical drugs. Most importantly, they can be more specific for their target receptor in the body, while at the same time, offering more precise control over receptor function. They can do this because they bind to cell surface receptors at a different site than traditional drugs. Although allosteric binding sites offer greater control, molecules that bind them cannot be identified using conventional high throughput screening techniques.

Society for Neuroscience 2010 Presentations

Sun, Nov 14, 8:00 - 9:00 AM
162.9/V17 - Novel triazinedione derivatives as GABAB receptor positive allosteric modulators: Synthesis, in vitro pharmacological characterization, pharmacokinetic profile and in vivo activity in rodent model of anxiety

Mon, Nov 15, 8:00 - 9:00 AM
406.9/MMM57 - An mGluR2/3 negative allosteric modulator improves recognition memory assessed by natural forgetting in the novel object recognition test in the rat

Mon, Nov 15, 2:00 - 3:00 PM
514.14/OOO34 - Validating the role of mGluR4 receptors in the physiopathology of anxiety using a selective mGluR4 positive allosteric modulator

Tue, Nov 16, 11:00 AM - 12:00 PM
557.12/M18 - Anti-parkinsonian and anti-dyskinetic effects of ADX48621, a novel mGlu5 negative allosteric modulator

Tue, Nov 16, 1:00 - 2:00 PM
642.5/E29 - JNJ-40068782: A novel potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor

Tue, Nov 16, 2:00 - 3:00 PM
643.22/F23 - Identification and characterization of radioligands that bind to an allosteric modulator site on the mGlur4 receptor

Tue, Nov 16, 3:00 - 4:00 PM
651.15/I6 - Selective mGluR2 negative allosteric modulators reverse the scopolamine-induced deficit in the novel object recognition test

Wed, Nov 17, 2:00 - 3:00 PM
886.14/VV7 - Effects of a mGluR2/3 negative allosteric modulator and a reference mGluR2/3 orthosteric antagonist in a genetic mouse model of depression

Wed, Nov 17, 3:00 - 4:00 PM
885.11/TT19 - Development of a cAMP BRET cellular HTS assay to characterize pharmacological properties of mGluR7 ligands


Contact: Mike Sinclair
Halsin Partners

Related medicine news :

1. Mayo Clinic Proceedings: November highlights
2. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
3. New study highlights sexual behavior, condom use by US individuals ages 14 to 94
4. 2010 AAO-HNSF new research daily highlights: Wednesday, Sept. 29, 2010
5. Medicinal cannabis review highlights dilemmas facing health care professionals
6. AWARD Fellowship highlights critical role of African women in agricultural research
7. Trainee publication highlights success of US-China agricultural injury research training project
8. Patient safety highlights American Association of Physicists in Medicine
9. Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010
10. STDTestExpress Highlights National HIV Testing Day with Free HIV Testing
11. Survey highlights major Canada-US differences in people in middle age
Post Your Comments:
(Date:10/10/2015)... ... October 10, 2015 , ... The Bank of America 500 NASCAR Sprint Cup ... Saturday, October 10th, defending race winner, Kevin Harvick, will battle it out for the ... and all of the stars of the NASCAR Sprint Cup Series. As part ...
(Date:10/10/2015)... ... October 10, 2015 , ... In the inaugural people’s choice contest, entitled Bold ... Work in Jacksonville, amongst medium-sized companies with 25 – 99 employees. The announcement was ... a celebratory gala on October 1st. , Many of the features of the ...
(Date:10/9/2015)... ... October 09, 2015 , ... With the FCPX LUT Vibrance pack ... footage. A LUT is a Lookup Table that contains a mathematical formula for modifying ... the table. This pack comes with 60 vibrant CUBE LUT files. , ...
(Date:10/9/2015)... CA (PRWEB) , ... October 09, 2015 , ... ... now offering a special promotion on Invisalign, the orthodontic system that uses clear, ... The aligners are almost invisible against the teeth, which allow patients to complete ...
(Date:10/9/2015)... ... 09, 2015 , ... Confidence Plus Insurance has just celebrated ... initiative that involves working with a series of local charities throughout the California ... Insurance is the Gleason Park Electric Violin Ensemble (GPEVE). , GPEVE provides a ...
Breaking Medicine News(10 mins):
... , New Report Highlights Best and Worst State ... Va., Sept. 10 A new report by The Vision Council, ... for children entering school are inconsistent, impeding children,s ability to succeed ... visual processing of information, undetected vision problems can severely impact a ...
... largest network of Hispanic health advocates joins President Obama,s efforts to improve ... , WASHINGTON, Sept. 9 "There was a clear ... reform. We need to work together to get the job done and ... our history, it is essential that we do this to support America,s ...
... , Statement attributable to: J. James Rohack, M.D. President, ... that Medical Liability Reform is Needed , , ... is unacceptable. The AMA will continue to work for reform that makes ... opportunity this year to achieve meaningful health reform for America,s patients and ...
... Sept. 9 In commemoration of the first September 11 National ... Los Angeles will host three 2-hour volunteer orientations for 100+ youth and ... tour of the chapter,s new state of the art Emergency Operation Center, ... recent California wildfires. , , What: ...
... MECHANICSBURG, Pa., Sept. 9 Select Medical Holdings ... the launch of its initial public offering of 33,333,333 shares ... is expected to be between $11.00 and $13.00 ... of common shares by Select, and Goldman, Sachs & Co., ...
... 9 As the nation awaits President Obama,s address on ... Philanthropic Collaborative (TPC) sent today a letter to the President ... foundations in the field of health. , , ... the social and economic effectiveness of health-related philanthropic activities. ...
Cached Medicine News:
(Date:10/8/2015)... Oct. 8, 2015  Allergan plc (NYSE: AGN ... it will hold its R&D Day on November 4, ... – to 1:00 p.m. PT). The company will also ... at 9:00 a.m. ET (6:00 a.m. PT). ... --> Logo - ...
(Date:10/8/2015)... CAMBRIDGE, Mass. , Oct. 8, 2015 /PRNewswire/ ... has awarded approximately $40 million to the Broad ... whole genome sequencing of 20,000 individuals, as well ... sequencing and metabolite profiling. Trans-Omics for ... an initial step toward a larger initiative, which ...
(Date:10/8/2015)... FRANCISCO , Oct. 8, 2015  Nektar Therapeutics ... the Company,s pain and oncology portfolio during an Investor ... - 3:30 p.m. Eastern Time in New ... carcinoma.  Details of the NKTR-214 Phase 1/2 clinical program ... CD122-biased immune-stimulatory cytokine designed to preferentially stimulate the production ...
Breaking Medicine Technology:
... (SIX: RO, ROG; OTCQX: RHHBY) announced today that the David ... be using the Roche LightCycler ® 480 System, a ... gene expression and genetic variation, in advanced cancer research. ... 480 System to support several key areas of research it ...
... 2011 /PRNewswire/ -- Royal Philips Electronics ... States availability of the Ingenia MRI system, the ... Previously available in Europe, Canada and Japan, the ... Food and Drug Administration. Driven by Philips commitment ...
Cached Medicine Technology:
CDIs new improved Implant Stabilizer has super-soft elastic bands with lace trim....
Bras and Breast Support...
Post-Surgical compression garments...
... The Albumin Cobalt Binding (ACB®) Test is ... Modified Albumin (IMA®) by measuring the cobalt ... serum sample. First identified in the early ... comes in contact with ischemic tissue in ...
Medicine Products: