Navigation Links
Addex highlights strength of allosteric modulation technology platform
Date:11/12/2010

Geneva, Switzerland, 12 November 2010 Allosteric modulation company Addex Pharmaceuticals (SIX:ADXN) announced today that data on a total of nine therapeutic programs will be presented during Society for Neuroscience 2010 (November 13-17, San Diego, USA), highlighting the strength of its allosteric modulation technology platform. The data being presented cover multiple receptor types and therapeutic areas, including Parkinson's disease, schizophrenia, anxiety, Alzheimer's disease and depression.

"The data generated by Addex and our partners, Ortho-McNeil-Janssen and Merck & Co., being presented at the Society for Neuroscience 2010 conference illustrate the power of our allosteric modulation product generating engine. Although the targets we are addressing have been pursued for many years with standard discovery technologies, most have proven elusive," explained Dr. Vincent Mutel, CEO of Addex. "Our technology is allowing us to bring a new kind of chemistry to industrial drug discovery efforts and thereby improve discovery productivity, a key bottleneck hindering the pharmaceutical industry. Beyond our presentations at Society for Neuroscience this year, we have recently demonstrated our ability to expand our discovery technology beyond GPCRs, like glutamate receptors, to cover other types of cell surface receptors, such as cytokine receptors, including TNF receptors. In addition to advancing our own molecules, we will look to sign multiple collaborative partnerships to realize the potential of our platform."

Small molecule allosteric modulators represent an unexploited kind of chemistry which is different from the traditional small molecule drugs. Orally available allosteric modulators can offer multiple competitive advantages over classical drugs. Most importantly, they can be more specific for their target receptor in the body, while at the same time, offering more precise control over receptor function. They can do this because they bind to cell surface receptors at a different site than traditional drugs. Although allosteric binding sites offer greater control, molecules that bind them cannot be identified using conventional high throughput screening techniques.

Society for Neuroscience 2010 Presentations

Sun, Nov 14, 8:00 - 9:00 AM
162.9/V17 - Novel triazinedione derivatives as GABAB receptor positive allosteric modulators: Synthesis, in vitro pharmacological characterization, pharmacokinetic profile and in vivo activity in rodent model of anxiety

Mon, Nov 15, 8:00 - 9:00 AM
406.9/MMM57 - An mGluR2/3 negative allosteric modulator improves recognition memory assessed by natural forgetting in the novel object recognition test in the rat

Mon, Nov 15, 2:00 - 3:00 PM
514.14/OOO34 - Validating the role of mGluR4 receptors in the physiopathology of anxiety using a selective mGluR4 positive allosteric modulator

Tue, Nov 16, 11:00 AM - 12:00 PM
557.12/M18 - Anti-parkinsonian and anti-dyskinetic effects of ADX48621, a novel mGlu5 negative allosteric modulator

Tue, Nov 16, 1:00 - 2:00 PM
642.5/E29 - JNJ-40068782: A novel potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor

Tue, Nov 16, 2:00 - 3:00 PM
643.22/F23 - Identification and characterization of radioligands that bind to an allosteric modulator site on the mGlur4 receptor

Tue, Nov 16, 3:00 - 4:00 PM
651.15/I6 - Selective mGluR2 negative allosteric modulators reverse the scopolamine-induced deficit in the novel object recognition test

Wed, Nov 17, 2:00 - 3:00 PM
886.14/VV7 - Effects of a mGluR2/3 negative allosteric modulator and a reference mGluR2/3 orthosteric antagonist in a genetic mouse model of depression

Wed, Nov 17, 3:00 - 4:00 PM
885.11/TT19 - Development of a cAMP BRET cellular HTS assay to characterize pharmacological properties of mGluR7 ligands


'/>"/>

Contact: Mike Sinclair
msinclair@halsin.com
44-207-318-2955
Halsin Partners
Source:Eurekalert

Related medicine news :

1. Mayo Clinic Proceedings: November highlights
2. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
3. New study highlights sexual behavior, condom use by US individuals ages 14 to 94
4. 2010 AAO-HNSF new research daily highlights: Wednesday, Sept. 29, 2010
5. Medicinal cannabis review highlights dilemmas facing health care professionals
6. AWARD Fellowship highlights critical role of African women in agricultural research
7. Trainee publication highlights success of US-China agricultural injury research training project
8. Patient safety highlights American Association of Physicists in Medicine
9. Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010
10. STDTestExpress Highlights National HIV Testing Day with Free HIV Testing
11. Survey highlights major Canada-US differences in people in middle age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... ... April 29, 2017 , ... TransDark is a set of dynamic transitions ... the next without having to set a single keyframe in Final Cut Pro ... video production. , TransDark features dynamic transitions that momentarily splits the RGB layers of ...
(Date:4/28/2017)... ... April 28, 2017 , ... An April 24th article on Yahoo! Beauty discusses ... with the help of a weight loss surgery. The woman, declaring “I will not hate ... been left following her dramatic weight loss. Dr. Feiz & Associates notes that, while it ...
(Date:4/28/2017)... ... 2017 , ... Beginning in 2017, Ridgecrest Herbals will be phasing out the ... ClearLungs Extra Strength formula. To ensure that the effectiveness of Clear Lungs Extra Strength ... , Removal of the homeopathic element , Adding their ...
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio ... These lamps offer an instant energy-saving solution for F32T8 fluorescent lamps on most ... disconnect ballasts. These 50,000 hour rated lamps utilize the existing electronic ballast, saving ...
(Date:4/28/2017)... ... April 28, 2017 , ... From April 30 to May ... Medicine will host industry leaders for the annual spring Convention & Expo, called ... industry adapt to the issues currently affecting urgent care and on-demand healthcare. , ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  RXi Pharmaceuticals Corporation (NASDAQ: RXII), ... address significant unmet medical needs, today announced that ... consumer product development program, based on its proprietary ... Investigative Dermatology (SID) 76 th Annual Meeting.  ... the sciences relevant to skin health and disease ...
(Date:4/20/2017)... 20, 2017   ZappRx, Inc ., a digital health ... process, today announced it closed $25 million in Series B ... firm based in Seattle that is ... . The Series B round included participation from SR ... and GV (formerly Google Ventures). As part of ...
(Date:4/20/2017)... -- Eyevensys, a private biotechnology company developing ... technology that enables the safe, local, sustained production of ... range of ophthalmic diseases, announces it has received approval ... (MHRA) to advance its technology into clinical development. ... The EyeCET platform ...
Breaking Medicine Technology: