Navigation Links
Added benefit of the fixed combination of dapagliflozin and metformin is not proven
Date:5/15/2014

mmissioned IQWiG to also assess not only studies on glibenclamide and glimepiride, but also on glipizide in each case combined with metformin in the first research question.

Drugs were not used in compliance with their approval

The drug manufacturer presented results of a study that directly compared the fixed combination with glipizide plus metformin. In this study, however, which had already been the basis for its dossier on the monotherapy, the drugs were not used according to the specifications in the approval both in the intervention and in the control arm. It remained unclear whether the same effects would have been observed if the drugs had been administered in compliance with the Summary of Product Characteristics. At any rate, the study results cannot be interpreted with regard to the approval-compliant use.

Insulin therapy could not be optimized

For the second research question, in which the fixed combination was to be complemented with insulin, the manufacturer used three studies, which it had also already cited in the dossier on the monotherapy. However, their results could also not be used for assessing the added benefit. The main reason for this is that the insulin therapy could not be tailored sufficiently to the individual patient: Even though their current insulin therapy was insufficient, patients were neither supposed to change the insulin nor to adapt the dose. But to be able to draw conclusions about the added benefit, the fixed combination would have to be compared with other strategies for optimizing treatment, for example optimizing insulin use.

Not tailoring treatment to the individual patient does not meet the current standard of diabetological practice anyway. Instead, insulin therapy is optimized for the individual patient so that hyperglycaemia and hypoglycaemia do not occur in the first place. So in the study, insulin was not used in a way that would be necessary and appropr
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. No Added Cancer Risk From Hip Replacement Materials: Study
2. Tafamidis: Approval denotes proven added benefit
3. Nurse Alert Provides Added Level of Senior Alert Care With New Nurse Triage Feature
4. Abiraterone: Indication of considerable added benefit in certain patients
5. Collagenase for Dupuytrens contracture: Added benefit not proven
6. Added benefit of linagliptin is not proven
7. Added benefit of eribulin in breast cancer is not proven
8. Added benefit of fampridine is not proven
9. Belimumab for lupus erythematosus: Added benefit not proven
10. Keeping Up a Healthy Lifestyle Pays Off in Added Years: Study
11. Telaprevir: Added benefit in certain patients with hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... Washington, DC (PRWEB) November 23, 2014 ... monthly Tech Report , which features the latest ... a technology expert and reporter for NewsWatch, conducted the ... cameras are unique and powerful options in the car ... is rising and it can be hard to find ...
(Date:11/23/2014)... November 23, 2014 Today Zane ... for small businesses, announced their new on demand ... of Employer-Provided Health Insurance. , According ... greatest financial risk facing most American families. It ... small and large, when it comes to recruiting ...
(Date:11/22/2014)... Recently, UWDress.com, a successful wedding dress shop, has ... in order to prepare for the wedding season. All ... off. , UWDress.com is a reliable company that has ... the new items -- formal wedding guest attire. This new ... including superstar and princess. As one of the leading companies ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Setria® ... Administration (TGA) approved it for use “as a ... and listed within the Therapeutic Goods (Listing) Notice ... , Kyowa Hakko’s Setria® Glutathione will be exclusivity ... specialist that sources and imports fine chemicals to ...
(Date:11/22/2014)... "My friend went in for a mammogram and ... an inventor from Cambria Heights, N.Y. "To add insult ... time because the first results were inaccurate. Her misfortune ... MAMO EASY to offer a more comfortable way to ... from the pain normally involved with this procedure. The ...
Breaking Medicine News(10 mins):Health News:A Leader in Front and Rear Facing In-Car Cameras was Featured on NewsWatch Television on October 30, 2014 2Health News:Zane Benefits, Inc. Announces New Webinar on The End of Employer-Provided Health Insurance Now Available On-Demand! 2Health News:Formal Wedding Guest Attire Added to UWDress.com 2Health News:Setria® Glutathione Now Available in Australia 2Health News:Setria® Glutathione Now Available in Australia 3
... have arisen about the best approach whether it is public ... that more people want public services offering better health care ... Queen Elizabeth Hospital is an example financial difficulty due to ... study reveals that the health care provided by the not-for-profit ...
... a well-known fact that nearly 1/3rd of our lifetime is ... important as the quantity. People who have odd working hours ... chronic sleep deprivation that is responsible for fatigue and other ... North Polar Region have for the first time shed light ...
... the University of Washington researchers between obesity and asthma. ... the Journal of Allergy and Clinical Immunology. Previous studies ... develop asthma. The new research reveals the common genetic ... ,The researchers led by Dr. Teal Hallstrand analyzed ...
... French are reluctant to place their orders for Christmas turkeys ... ,However, the dreaded disease has not stopped the British and ... year, say industry sources. ,In France, bulk ... orders, say industry sources. The consumer confidence seems to have ...
... on bird shows in Britain has been lifted on account of ... ,Various events such as pigeon racing, falconry and other bird shows ... bird flu scare in October which was detected in Eastern Europe ... now since no single case of bird flu was reported the ...
... regarding the Christmas dinner. Turkey still remains popular inspite of the ... risen by 25% in Britain. Supermarket owners say that the sales ... ,When bird flu was spreading and was in its peak ... sales will fall very sharply. ,But the health officials ...
Cached Medicine News:Health News:Reindeer Provide Valuable Insights Into Sleep Disorders 2Health News:Christmas turkey? Anyone? 2
(Date:11/22/2014)... LONG BEACH, Calif. , Nov. 21, 2014   ... implants. Dental implants are often called the gold standard in ... teeth. They are a stable, long-lasting way to restore and ... use dental implants to replace a missing tooth or as ... to completely transform the look and feel of a smile. ...
(Date:11/22/2014)... 21, 2014 Many power shifts are ... influence of patients in the biopharmaceutical market is ... more than ever, understanding how to effectively acquire, ... is essential. According to recent ... companies spent about two-thirds of their patient-focused dollars ...
(Date:11/21/2014)... In September 2014, the staff at Medelita ... new product development plan that started with the launch ... lab coat , aptly named "Vera G.," after one ... world. The new women,s designer lab coat is a ... envelope collar, vertical princess and high waist seaming, and ...
Breaking Medicine Technology:Long Beach Dentist, Dr. Rassouli, is Now Offering Dental Implants 2New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2
... AstraZeneca (NYSE:,AZN) today announced that the U.S. Food ... (quetiapine fumarate) Extended-Release,Tablets for maintenance treatment of schizophrenia ... approved SEROQUEL XR for the acute treatment of,schizophrenia ... rates of symptom relapse, and as,a result, there ...
... from Fort Point Channel to the Cyclorama mark 16th Annual,24-hour ... thousands of youth to process with black and copper buckets ... The Boston Center,for the Arts as part of the annual ... event was named Best Project in a Public Space by ...
Cached Medicine Technology:SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 2SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 3SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 4SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 5SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 6SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 7SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 8Award-Winning Medicine Wheel Returns to the Cyclorama at the Boston Center for the Arts on Dec. 1 for 24-hour Vigil Recognizing World AIDS Day 2Award-Winning Medicine Wheel Returns to the Cyclorama at the Boston Center for the Arts on Dec. 1 for 24-hour Vigil Recognizing World AIDS Day 3Award-Winning Medicine Wheel Returns to the Cyclorama at the Boston Center for the Arts on Dec. 1 for 24-hour Vigil Recognizing World AIDS Day 4
... DAPII brain biopsy needle guide housing. ... Screw mount. Placed through a ... Non-sterile; sterilize via autoclave Guide sphere assembly ... with biopsy needles with barium sleeves. Sterile; ...
A complete system of cannulas, needles and rasps specifically designed for inside-out meniscal repair procedures....
Part of the GraFix® Cruciate Reconstruction System, which is designed to facilitate arthroscopic anterior cruciate ligament reconstructions....
... (KGTI) system offers the latest technology and ... The implant system is anatomically designed and ... KGTI is the most advanced reconstructive device ... the market today. The system consists of ...
Medicine Products: