Navigation Links
Added benefit of saxagliptin/metformin combination is not proven
Date:4/29/2013

>Regarding the combination with insulin, the manufacturer submitted a study that directly compared saxagliptin/metformin and insulin with metformin und human insulin. But the results of this study cannot be used for the assessment of the added benefit.

The main reason for this is that the insulin therapy could not be tailored sufficiently to the individual patient in the first treatment phase: even though their current insulin therapy was insufficient, patients were neither supposed to change the insulin nor to adapt the dose. But to be able to draw conclusions about the added benefit, the combination of saxagliptin/metformin and insulin would have to be compared with other strategies for optimizing treatment, for example optimizing insulin use.

Not tailoring treatment to the individual patient does not meet the current standard of diabetological practice anyway. Instead, insulin therapy is optimized for the individual patient so that hyperglycaemia and hypoglycaemia do not occur in the first place. So in the study, insulin was not used in a way that would be necessary and appropriate in this indication.

Therefore, there are no study results for either of the two therapeutic indications of the fixed combination saxagliptin/metformin from which an added benefit could be derived.

G-BA decides on the extent of added benefit

The dossier assessment is part of the overall procedure for early benefit assessments supervised by the G-BA. After publication of the manufacturer's dossier and IQWiG's assessment, the G-BA conducts a commenting procedure, which may provide further information and result in a change to the benefit assessment. The G-BA then decides on the extent of the added benefit, thus completing the early benefit assessment.


'/>"/>

Contact: Anna-Sabine Ernst
presse@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Left Coast Marijuana Delivery Service Added To Top-Tier Dispensary Locator
2. BPA Added To California’s Toxic Chemicals List Making BPA-Free Dental Products from PureLife More Attractive
3. Astro-Clairvoyant Norah Guide With Premium Astrology Extends Blog Series With Newly Added Video Features
4. New Karlsson Vintage Wall Clocks Added at Contemporary Heaven
5. Innovative Medical Marijuana Growing Product added to PotLocator.com Lineup
6. Master Numerologist at Numerology Secret Added New Rave Reviews To His Testimonial Base
7. New Lines Added to the Arti & Mestieri Clocks Range at Contemporary Heaven US
8. Perampanel for epilepsy: No proof of added benefit
9. Added benefit of aclidinium bromide is not proven
10. Linagliptin: Once again, no proof of added benefit
11. New Wall Clocks Added to the Balvi Range at Contemporary Heaven
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... With the Affordable Care Act (ACA) open enrollment period starting ... Research (AIR) finds that three out of four Americans are ... percent say they are not likely or only somewhat likely ... , The AIR survey found wide gaps in Americans’ health ... how much they owe for a routine doctor’s visit. , ...
(Date:10/22/2014)... 2014 Although there are only 24 hours in ... people who have trouble finding time within their busy schedules for ... long periods of time to get in shape. Here are five ... the go. , Change Up Your Commute , Consider riding ... add some exercise into your daily routine. If you must use ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter , ... in vitro fertilization (IVF) are only about half as likely ... reproduction technique, new research indicates, and the racial disparity persists ... about 31 percent of white patients became pregnant after IVF, ... more than 4,000 IVF cycles over two years to tease ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... health officials on Monday officially tightened guidelines for health workers ... skin exposure and use of a respirator at all times. ... to issue the tougher rules after two Dallas nurses contracted ... the United States, Liberian national Thomas Eric Duncan. Nina Pham ...
(Date:10/20/2014)... The Advocator Group, LLC is proud ... for Suicide Prevention’s (AFSP) Out of the Darkness walk ... that hosts hundreds of community walks throughout the country ... to help understand and prevent suicide through not only ... , The Advocator Group shares this passion for ...
Breaking Medicine News(10 mins):Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3
... WASHINGTON, July 14, 2009 News media covering chemical ... an American Chemical Society (ACS) Small & Medium Business ... professionals, scientists and entrepreneurs. Scheduled for ... the webinar will feature Kenneth Polk, who joined ACS ...
... , , VIENNA, July 14 ... in moderate physical activity may help preserve our memory and thinking ... the Alzheimer,s Association 2009 International Conference on Alzheimer,s Disease (ICAD 2009) ... http://www.newscom.com/cgi-bin/prnh/20090529/ICADLOGO ) ...
... KUALA LUMPUR, Malaysia, July 14 Ramuan , a little-known secret ... will be revealed to a global audience for the first time ... and Beauty from the Rainforest: Malaysian Traditions of Ramuan, and ... lifestyle approach to wellness, ramuan literally means in Malay ...
... WASHINGTON, July 14 To help the general public better ... National Council on Skin Cancer Prevention has issued a position ... The Council recommends that vitamin D be obtained from a ... exposure to ultraviolet (UV) radiation. , ...
... , SCHAUMBURG, Ill., July 14 The American ... D after an updated review of the increasing body of scientific literature ... , The Academy continues to recommend that ... not from unprotected exposure to ultraviolet (UV) radiation from the sun or ...
... ... Percent of Employers Say the System is Crucial to Limiting Health Plan Costs ... Bethesda, MD (PRWEB) ... companies to better manage their healthcare costs by analyzing their benefit programs to understand ...
Cached Medicine News:Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 2Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 3Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 4Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 5Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 6Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 7Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 8Health News:U.S. Debut: Holistic Health And Beauty From The Rainforest - New Book Reveals Closely Guarded Malaysian Health and Beauty Secrets Introducing the World to Time-Honored Tradition of Ramuan 2Health News:U.S. Debut: Holistic Health And Beauty From The Rainforest - New Book Reveals Closely Guarded Malaysian Health and Beauty Secrets Introducing the World to Time-Honored Tradition of Ramuan 3Health News:National Council on Skin Cancer Prevention Encourages Americans to Obtain Vitamin D Through Diet and Supplements 2Health News:American Academy of Dermatology Issues Updated Position Statement on Vitamin D 2Health News:American Academy of Dermatology Issues Updated Position Statement on Vitamin D 3Health News:American Academy of Dermatology Issues Updated Position Statement on Vitamin D 4Health News:WellNet Introduces Facebook-like Point to Point Healthcare 2Health News:WellNet Introduces Facebook-like Point to Point Healthcare 3Health News:WellNet Introduces Facebook-like Point to Point Healthcare 4
(Date:10/22/2014)... Oct. 22, 2014 AVACEN Medical announced today ... 510 (k) OTC clearance by the U.S. Food and ... be marketed over the Internet for: the temporary ... and minor strains and sprains . Logo ... 100 (MSRP $2495) is a sophisticated medical device incorporating ...
(Date:10/22/2014)... Oct. 22, 2014  With a vision to ... medications, a Global Pharmaceutical and Biotech manufacturer selects ... and turnkey solution to protect their animal health ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... serialized and aggregated by the Xyntek and Antares ...
(Date:10/22/2014)... 21, 2014  Early symptoms of diabetic eye ... but new technology, coupled with yearly, comprehensive eye ... earlier detection of eye diseases, including those associated ... If left untreated, these diseases can potentially lead ... Recently, optometric researchers have deployed a new ...
Breaking Medicine Technology:AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2Xyntek and Antares Serialization Solution Protects Pets Too! 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3
... N.J., Oct. 10, 2011 The New Jersey Patient Care ... the Garden State, encourages men and their families to speak ... Preventive Services Task Force (USPSTF) recommended healthy men should no ... routine cancer screening. This decision was made ...
... 10, 2011 IRIDEX Corporation (Nasdaq: IRIX ) ... President and Chief Executive Officer effective today. Dr. Beck replaces ... Chief Technology Officer, and will also replace Mr. Boutacoff on ... has spent the majority of his career in leadership and ...
Cached Medicine Technology:NJ Docs Say Cancer Detection Tool Saves Lives 2IRIDEX Names Veteran Healthcare Executive Dominik Beck President, CEO 2IRIDEX Names Veteran Healthcare Executive Dominik Beck President, CEO 3IRIDEX Names Veteran Healthcare Executive Dominik Beck President, CEO 4
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Each handle is designed to fit a specific trephine size....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medicine Products: