Navigation Links
Added benefit of Cannabis sativa for spasticity due to multiple sclerosis is not proven
Date:9/17/2012

An extract from the plant Cannabis sativa (trade name Sativex) was approved in May 2011 for patients suffering from moderate to severe spastic paralysis and muscle spasms due to multiple sclerosis (MS). In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether the new drug, which is used as a mouth spray, offers an added benefit over the optimized standard therapy. However, no such added benefit can be inferred from the dossier, as the drug manufacturer deviated from the specifications of the Federal Joint Committee (G-BA) and chose a different comparator therapy.

Comparison of different possibilities for optimizing treatment

The extract from Cannabis sativa, which contains the active ingredient combination of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), is approved as add-on therapy to the already used antispastic drugs. Usually, drugs such as baclofen or tizanidine are given to treat muscle spasms. The cannabis extract can be considered when, despite an individual, patient-tailored use of these drugs, the symptoms caused by spasticity cannot be adequately relieved.

The G-BA specified an optimized standard therapy containing baclofen, tizanidine or drugs that are approved for the treatment of spasticity in underlying neurological diseases as the appropriate comparator therapy. At least two previous attempts at treatment were to have been made, in each of which different oral antispastic (spasmolytic) drugs had been used in an optimum way. Again, at least one product was to have contained the active ingredients baclofen or tizanidine. The aim of the assessment by IQWiG was to compare the additional administration of the Cannabis sativa extract with other available possibilities for optimizing treatment and to assess the added benefit.

Opti
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
49-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Tafamidis: Approval denotes proven added benefit
2. Telaprevir: Added benefit in certain patients with hepatitis C
3. Keeping Up a Healthy Lifestyle Pays Off in Added Years: Study
4. Belimumab for lupus erythematosus: Added benefit not proven
5. Added benefit of fampridine is not proven
6. Added benefit of eribulin in breast cancer is not proven
7. Added benefit of linagliptin is not proven
8. Collagenase for Dupuytrens contracture: Added benefit not proven
9. Abiraterone: Indication of considerable added benefit in certain patients
10. Nurse Alert Provides Added Level of Senior Alert Care With New Nurse Triage Feature
11. Tafamidis: Approval denotes proven added benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... CA (PRWEB) August 21, 2014 Sleep Apnea ... across the U.S. This provides doctors with a convenient way ... find a doctor are that much closer to finding ... have no idea they are experiencing this sleep disorder ... receive treatment at all. , Thanks to Sleep Apnea Doctors ...
(Date:8/21/2014)... Cary, NC (PRWEB) August 21, 2014 ... solutions for the health and human services markets, announced ... features and capabilities incorporating the Tin Can API. ... and their employees have the most advanced mobile learning ... greatest in adult learning tools and techniques,” says Jim ...
(Date:8/21/2014)... ERT, a leading global solution ... endpoint data collection, today opened registration for ... Product Value with Optimized Endpoints. The ... developers to network with leading researchers as ... implementing, and justifying effective strategies for collecting ...
(Date:8/21/2014)... elicited by T-type calcium channels in the thalamic ... of calcium. These channels enable thalamic reticular nucleus ... to enter a hyper-excited state. , In order ... absence seizures, the researchers conducted an experiment to ... techniques to delete the T-type calcium channel CaV3.3. ...
(Date:8/21/2014)... Do we drive to work or take the train? From ... make hundreds of different decisions every day. Even if these ... for our long-term personal development to make decisions that are ... difficult, however. They are known to make impulsive decisions, often ... of making a choice that yields a greater reward later ...
Breaking Medicine News(10 mins):Health News:Sleep Apnea Doctors US is Now Offering Complimentary Listings to Sleep Apnea Doctors Across the United States 2Health News:Relias Learning Announces Support for Tin Can API 2Health News:ERT Opens Registration for PROFICIENCY™ Regional Conference Series 2Health News:ERT Opens Registration for PROFICIENCY™ Regional Conference Series 3Health News:ADHD children make poor decisions due to less differentiated learning processes 2
... SOUTH SAN FRANCISCO, Calif., July 29 Poniard Pharmaceuticals, Inc. ... innovative oncology therapies, today announced that Jerry McMahon, Ph.D., chairman ... overview, including a discussion about the clinical development program for ... conferences: , , , ...
... , SAN DIEGO, July 29, 2009 Arena ... will report second quarter 2009 financial results after the NASDAQ ... afternoon, Jack Lief, Arena,s President and Chief Executive Officer, and ... Officer, will host a conference call at 5:00 p.m. Eastern ...
... , JACKSONVILLE, Fla., July 29 Today, Wounded ... bill (H.R. 3155) that will assist the family caregivers of ... (S. 801) that would provide more comprehensive support and coverage ... need of these services. H.R. 3155, the Caregiver Assistance and ...
... SAN FRANCISCO, July 29 Medivation, Inc. (Nasdaq: ... and webcast with management to discuss second quarter 2009 financial results ... at 4:30 p.m. Eastern Time. A press release for the second ... on August 5, 2009. , , Interested parties ...
... , , , , ... Carefx Corporation , a leading provider of interoperable workflow ... that one of its clients, the Louisiana Rural Health Information Exchange (LARHIX), ... Health Information Executives , a top healthcare information technology magazine. ...
... , , MONROVIA, ... ), a leading developer, manufacturer and marketer of minimally invasive ophthalmic ... Officer will present at the BMO Capital Markets 9th Annual Focus ... 5th at 4:00 pm Eastern Time. , , ...
Cached Medicine News:Health News:Poniard Pharmaceuticals to Present at Two Upcoming Investor Conferences in August 2Health News:Arena Pharmaceuticals to Host Business and Financial Update Conference Call and Webcast on Monday, August 3, 2009 2Health News:Arena Pharmaceuticals to Host Business and Financial Update Conference Call and Webcast on Monday, August 3, 2009 3Health News:Wounded Warrior Project (WWP) Pushes for Senate Bill to Assist Family Caregivers of the Most Severely Injured Veterans 2Health News:Medivation Announces Second Quarter 2009 Financial Results Teleconference and Webcast on August 5, 2009 2Health News:Top Healthcare Magazine Awards Carefx Client '2009 IT Project of the Year' 2Health News:Top Healthcare Magazine Awards Carefx Client '2009 IT Project of the Year' 3
(Date:8/21/2014)... Inc. (NASDAQ: CYBX ) today announced results for ... highlights 1   Operating results for the first ... fiscal 2014, and other achievements, include: , Worldwide net ... , Strong international net sales of $13.2 million, an increase ... net product sales reached a new high of $58.8 million, ...
(Date:8/21/2014)... 2014 Asterias Biotherapeutics, Inc. (OTCBB: ASTY), a ... medicine, announced today the appointments of Andrew ("Andy") Arno ... Board of Directors. With these additions, the Asterias Board ... are independent. Andy Arno , 55, ... companies. He is currently Managing Director of Emerging Growth ...
(Date:8/20/2014)... HOLBROOK, N.Y. , Aug. 20, 2014 /PRNewswire/ ... MDIN) today announced that after months of hard ... finally finished the new Snorenz formulation and package ... vitamins E and B-6 back into the product ... well as longer lasting effects.  Snorenz Nighttime will ...
Breaking Medicine Technology:Cyberonics Reports Fiscal 2015 First Quarter Results 2Cyberonics Reports Fiscal 2015 First Quarter Results 3Cyberonics Reports Fiscal 2015 First Quarter Results 4Cyberonics Reports Fiscal 2015 First Quarter Results 5Cyberonics Reports Fiscal 2015 First Quarter Results 6Cyberonics Reports Fiscal 2015 First Quarter Results 7Cyberonics Reports Fiscal 2015 First Quarter Results 8Cyberonics Reports Fiscal 2015 First Quarter Results 9Cyberonics Reports Fiscal 2015 First Quarter Results 10Cyberonics Reports Fiscal 2015 First Quarter Results 11Cyberonics Reports Fiscal 2015 First Quarter Results 12Cyberonics Reports Fiscal 2015 First Quarter Results 13Cyberonics Reports Fiscal 2015 First Quarter Results 14Cyberonics Reports Fiscal 2015 First Quarter Results 15Cyberonics Reports Fiscal 2015 First Quarter Results 16Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 2Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 3Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 4Northstar completes the first phase of its new retail strategy and prepares to ship reformulated Snorenz with all new packaging 2
... W.Va., June 19 Keeping your teeth brushed and flossed can ... and stroke, dentists have warned for years. Now researchers at ... help preserve memory. , , The National Institutes of Health ... further build on studies linking gum disease and mild to moderate ...
... Florida,s First Three-Year Neuroscience Research Doctorate Program , ... Roskamp Institute (Roskamp) today announced the first enrollment ... through which students will conduct full-time laboratory research ... is an Affiliated Research Centre (ARC) of the ...
Cached Medicine Technology:School of Dentistry Studies Link Between Oral Health and Memory 2Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program 2Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program 3
... Speed Pre and Post High Vacuum Autoclaves. ... designed to cover a large of applications ... well as private clinics and dental offices. ... of medical and surgical materials such as ...
... manual autoclaves set the standard for steam ... to compliment any healthcare and laboratory facility. ... of your sterilization needs. Time tested reliability ... product. The Tuttnauer M Series is also ...
... is a confocal laser scanning microscope ... images of the posterior segment. It ... retinal topography and precise follow-up of ... routine application of Heidelberg Retina Tomograph ...
Subjective refraction unit, computer controlled and programmable. Two versions: with and without prisms....
Medicine Products: