Navigation Links
Adapting to clogged airways makes common pathogen resist powerful drugs
Date:2/9/2010

c fibrosis secretions contain a lot of nitrates and amino acids, which Pseudomonas can use to grow.

Inside mucus plugs oxygen levels are low. Some Pseudomonas strains can live in this oxygen-poor, nutrient-rich environment. Hoffman and his team found that a mutation that occurs commonly in Pseudomonas from cystic fibrosis patients allows the pathogen to grow better in the nutrient environment in cystic fibrosis secretions. This particular mutation inactivates a gene named lasR. Pseudomonas with this mutation apparently undergo a metabolic shift: consuming less oxygen while utilizing nitrate more efficiently. lasR mutant bacteria also can handle oxidative stress resulting from an imbalance of damaging substances called free radicals forming faster than they can be detoxified.

One source of oxidative stress encountered by Pseudomonas is the antibiotic treatment that is frequently given to people who have cystic fibrosis. Antibiotics like ciprofloxacin and tobramycin kill bacteria partly by inducing the overproduction of free radicals and causing oxidative stress. Hoffman and his team found that, because these mutant microbes are resistant to oxidative stress, they were relatively resistant to these antibiotics when grown in conditions that were like cystic fibrosis mucus.

"We learned that simply by adapting to the conditions inside the airways of cystic fibrosis patients, mutated Pseudomonas can withstand the effects of ciprofloxacin and tobramycin," Hoffman said. They did not need any previous exposure to these antibiotics to reduce their susceptibility.

Hoffman and his team suspect that Pseudomonas is not the only microbe that can do this. Some of the characteristics conferred by the mutation in Pseudomonas are also exhibited in other microbes found in chronic lung infections, such as tuberculosis or the fungal pathogen, Cryptococcus neoformans, Hoffman noted. M
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Adapting space-industry technology to treat breast cancer
2. 2009 Catholic Health Assembly to Focus on Hope in a Time of Hardship and Adapting for the Future in a Time of Health Reform
3. Adapting Gait May Help Elderly Avoid Falls
4. Adapting to pregnancy played key role in human evolution, study shows
5. Enzyme is key to clogged arteries
6. New Computerized Scans Effective for Spotting Clogged Arteries
7. High-tech CT scans: not a bad choice to test for clogged arteries
8. New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways
9. Data Published in Leading Respiratory Journal Reinforce Importance of Small Airways In Asthma Management
10. US Airways to Match Miles with Mercy Medical Airlift
11. Measles Spread Doesnt Depend on Airways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 2015 NOVAtime Technology, Inc. ( ... solutions for enterprise organizations, announced today that SanMar ... automate its time, attendance and point tracking processes ... the United States. , Family-owned since 1971, ... 21 retail, private label, and mill brands. SanMar ...
(Date:5/27/2015)... 27, 2015 The MedSpa at Hendrick ... dermal filler treatments in Abilene, Texas: Xeomin®, Belotero Balance® ... appearance of glabellar lines, better known as the lines ... is designed to treat smoker’s lines around the mouth ... while Radiesse® improves the appearance of smile lines or ...
(Date:5/27/2015)... IL (PRWEB) May 27, 2015 On ... North-based advertising agency, will partner with LifeSource to host ... event will take place in a LifeSource donor coach ... a.m. to 4:00 p.m. , Demand for whole blood ... in Illinois, during the summer months. LifeSource requires approximately ...
(Date:5/27/2015)... 2015 With InnerVoice Communication App ... the message is not only heard but seen -- by ... any motivating image. This award-winning and affordable app takes full ... Now, using InnerVoice Sender app in conjunction with ... a learner remotely for no additional cost. , InnerVoice ...
(Date:5/27/2015)... Columbus, Ohio (PRWEB) May 27, 2015 ... resulted in MediaSource and Roswell Park ... award. , The award-winning story, Cancer Can’t ... at the Roswell Park Cancer Institute. The production team ... journey for several months as they received treatment from ...
Breaking Medicine News(10 mins):Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 2Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 3Health News:The MedSpa at Hendrick Introduces Xeomin®, Belotero Balance® and Radiesse® Injectables 2Health News:Donate Your Break and Save Lives at the River North Blood Drive 2Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 2Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 3Health News:Newly Released: InnerVoice Sender App Ups the Ante in Communication Technology for Autism with Remote Prompting 4Health News:MediaSource Wins New York Emmy® Award as Premier Health Care Storytellers 2Health News:MediaSource Wins New York Emmy® Award as Premier Health Care Storytellers 3
... You,re visiting the dentist for what you think is a ... need a root canal. Though it,s a term you,ve probably ... you may have several questions and feel apprehensive about your ... quite some time. The Pennsylvania Dental Association (PDA) wants to ...
... , WASHINGTON, Nov. 12 Over the next several weeks, ... a major step toward improving food safety for all Americans. ... organizations and groups representing victims of foodborne illness is sending ... Safe for the Holidays!" , Every year, millions of Americans ...
... Mesa Laboratories, Inc. (Nasdaq: MLAB ) today announced ... dividend of $.11 per share of common stock, up from ... payable December 15, 2009, to shareholders of record on November ... has maintained strong cash positions and has continued to build ...
... Leader Harry Reid reportedly is moving closer toward a progressive ... The Associated Press late Wednesday reported that one of the ... more than $250,000 a year to pay a modest increase ... would bring in needed revenue to pay for comprehensive health ...
... use declined, so did incidence of abnormal cells in milk ... Declining use of hormone replacement therapy may be driving down ... risk factor for breast cancer, new research suggests. , This ... atypical ductal hyperplasia -- abnormal cells in the breast,s milk ...
... in the November issue of the Journal of the ... under 40 years old who undergo fertility preservation do not ... when their care is coordinated in a timely fashion. ... and reproductive endocrinologists is critical," said Lynn Westphal, MD, associate ...
Cached Medicine News:Health News:Painful Root Canals Are a Thing of the Past 2Health News:New Polls, Reports Highlight The Need To Update The U.S. Food Safety System And To 'Make Our Food Safe For The Holidays' 2Health News:New Polls, Reports Highlight The Need To Update The U.S. Food Safety System And To 'Make Our Food Safe For The Holidays' 3Health News:Reid Moves Toward Progressive Financing Measure to Help Fund Health Care Reform 2Health News:Less HRT, Fewer Cases of Possible Breast Cancer Precursor 2Health News:Less HRT, Fewer Cases of Possible Breast Cancer Precursor 3Health News:Fertility procedures need not delay breast cancer treatment for younger women 2
(Date:5/27/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/f6rkcf/north_america ) ... Portable X Ray Devices Market - Growth, Trends ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... for Portable X-Ray Devices is expected to grow ... X-Ray is a form of electromagnetic ...
(Date:5/27/2015)... May 27, 2015  LumiThera Inc., a developmental ... (PBM) treatment for ocular disorders and disease, announced ... Washington State Life Sciences Discovery Fund (LSDF) ... of the LSDF matching grants worth $500,000 to ... subjects with dry age-related macular degeneration (AMD). ...
(Date:5/27/2015)... , May 26, 2015 Research and Markets( http://www.researchandmarkets.com/research/ljsxt8/asia_pacific ... Portable X Ray Devices Market - Growth, Trends And Forecasts ... The Asia Pacific market for ... CAGR from 2014 to 2020 X-Ray is a ... abnormalities in the body, especially bones. The need of point ...
Breaking Medicine Technology:North America Portable X Ray Devices Market Report 2015 - Growth, Trends And Forecasts 2014-2019 2LumiThera Receives LSDF Commercialization Grant Award 2Asia Pacific Portable X Ray Devices Market 2015 - Trends And Forecasts to 2019 2
... Scripts (Nasdaq: ESRX ), one of the largest pharmacy ... to release its third quarter earnings on Wednesday, October 28, ... conference call to discuss third quarter results on Thursday, October ... Time). , This call is being webcast and can be ...
... VIEW, Calif., Oct. 1 IRIDEX Corporation (Nasdaq: ... laser fiber probe intended for effective delivery of laser ... at the 2009 American Academy of Otolaryngology-Head and ... consumable product represents an increase in IRIDEX, presence in ...
Cached Medicine Technology:Express Scripts Announces Third Quarter 2009 Earnings Conference Call 2IRIDEX Introduces New ENT Laser Delivery Devices at AAO-HNSF Annual Meeting 2
Lancets are the fine needles used with a lancing device to draw a blood sample for glucose testing. To make testing less painful, we developed lancets with extra-thin tips....
... HEMOCHRON Jr. Signature Microcoagulation System performs rapid ... just one drop (.015cc) of fresh whole ... hand-held, battery-operated instrument, the HEMOCHRON Jr. Signature ... print (optional) both patient and quality control ...
Inquire...
... ideal for hospital laboratories, blood bank laboratories ... laboratories. It fully automates the entire procedure ... from different manufacturers. The Genesis RMP easily ... 600'000 tests, using 4 needles, 8 needles ...
Medicine Products: