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Adamas Pharmaceuticals Expands Management Team; Names Michael D. Coffee and Amy K. Patick to Executive Positions
Date:8/25/2009

successful approval of Viracept (nelfinavir) for HIV infection. Most recently, Dr. Patick was Vice President, Biological Sciences at Genelabs Technologies. Dr. Patick earned her PhD in Medical Microbiology from the University of Wisconsin, and had postdoctoral training at the Mayo Clinic/Foundation in Rochester, MN. She is the co-author of more than 70 scientific publications and holds over 20 patents. She is the current President of the International Society for Antiviral Research.

About TCAD Therapy

Adamas is pioneering triple-combination antiviral drug (TCAD) therapy for influenza, which is designed to inhibit viral replication at multiple points in the virus proliferation pathway. TCAD therapy includes Adamas' investigational proprietary fixed-dose combination of amantadine and ribavirin, to be administered adjunctively with a neuraminidase inhibitor such as Tamiflu (oseltamivir phosphate, Roche). Preclinical data indicate that the in vitro combination of these drugs, each with their own mechanism of action, act synergistically to provide a much higher level of antiviral activity than single or double drug combination therapies. In in vitro studies to date, TCAD therapy also has been found to provide greater antiviral activity across multiple strains of influenza, even those resistant to single pharmaceutical agents. Adamas is accelerating development of its TCAD therapy for influenza A by conducting a Phase 2 clinical trial in the Southern Hemisphere where the novel influenza A/H1N1 pandemic is active, and is preparing to initiate a clinical study of TCAD therapy for influenza A in North America during this upcoming flu season.

About Adamas

Adamas is an emerging pharmaceutical company focused on developing small molecule, Advantaged Therapeutics to treat neurological and infectious diseases, including influenza A, the cause of the current flu pandemic.
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SOURCE Adamas Pharmaceuticals, Inc.
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