Navigation Links
Adalimumab therapy effective in AS, RA and PsA patients refractory to other anti-TNF therapies
Date:6/12/2008

. 54% of patients who had previously been intolerant of their medications reached ASAS20 and 37% reached ASAS40. Of those who had had no response to previous treatment, 41% reached ASAS20, and 27% achieved ASAS40.

Rheumatoid arthritis

66% of RA patients who had lost response to their previous anti-TNF treatment reached ACR20 (American Collage of Rheumatology 20% symptom improvement) after twelve weeks, and 36% reached ACR50 (50% symptom improvement). 67% of previously anti-TNF intolerant patients reached ACR20, and 39% attained ACR50. 51% of patients who had had no response to an anti-TNF in the past reached ACR20, and 26% achieved ACR50.

Psoriatic arthritis

42% of PsA patients who had previously undergone anti-TNF therapy achieved ACR50 and had a mean change in DAS28 of -2.1 after 12 weeks of adalimumab therapy.

About the Trials

Investigators examined patients with a disease duration of 9-12 years who were enrolled into three large, open-label studies: 1,250 AS patients in the RHAPSODY trial, 6,610 RA patients in ReAct, and 442 PsA patients in STEREO. All patients received 40mg adalimumab subcutaneously every other week for 12 weeks, in addition to their current antirheumatic treatment regimens. Patients with prior anti-TNF experience could only enroll into RHAPSODY or STEREO studies if infliximab therapy had been discontinued two months or longer previously and/or etanercept therapy had been discontinued three or more weeks previously. Those who entered the ReAct trial had to have discontinued etanercept and infliximab therapies two months or more prior to the start of the study.

In these three studies, adalimumab appeared to be well-tolerated in patients with prior anti-TNF treatment in all three disease groups.


'/>"/>

Contact: Rory Berrie / Camilla Dormer
eularpressoffice@uk.cohnwolfe.com
44-078-761-90439
European League Against Rheumatism
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis
2. Abbott Receives FDA Approval for HUMIRA(R) (Adalimumab) for Polyarticular Juvenile Idiopathic Arthritis
3. Abbott Study Examines Rates of Uveitis (Inflammation of the Eye) in Ankylosing Spondylitis Patients Treated with HUMIRA(R) (adalimumab)
4. Abbotts HUMIRA(R) (adalimumab) Honored With Prestigious Galen Prize for Innovation in Patient Care
5. Latest research on allergies: Specific immunotherapy can help
6. Anti-estrogen drug therapy reduces risk of invasive breast cancer in older women
7. Breakthrough Isolaz(TM) Acne Therapy Featured in U.S. News & World Report:
8. Solid tumor cells not killed by radiation and chemotherapy become stronger
9. Specialist nurses can play a key role in supporting patients having radiotherapy
10. Majority of U.S. House Supports Repeal of Medicare Therapy Caps
11. Hill-Rom Innovative TotalCare(R) Bariatric Plus Therapy System Receives Gold Medical Device Excellence Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... December 20, 2014 These vanadium reserves ... other nations. Around 151,000 tons of vanadium were produced ... global vanadium usage increased at 6.7% AAGR during the ... and iron industry, being the largest consumer, accounted for ... followed by titanium-vanadium alloy and the chemical industry. , ...
(Date:12/19/2014)... News) -- The intestinal bacteria that cause inflammatory bowel ... be inherited, researchers report. The findings, published recently ... in efforts to prevent the disease and treat the ... authors added. "The intestinal bacteria, or ,gut microbiome, ... a big impact on your health for the rest ...
(Date:12/19/2014)... (HealthDay News) -- The cost of cancer treatment can ... study finds. Researchers examined data from 1,000 people ... colorectal or lung cancer. Of those patients, almost 900 ... than 100 had advanced cancer. Nearly half of ... medical bills, which was linked with a poorer health-related ...
(Date:12/19/2014)... Kan. (PRWEB) December 19, 2014 B. ... exclusively to healthcare providers, has been retained to lead ... Estes Park Medical Center in Estes Park, Colo. The ... E. Smith has recently placed more than 900 healthcare ... (EPMC) is a 25-bed, not-for-profit critical access hospital and ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Pain Free ... is excited to announce a new Superior magnetic ... magnets. These are the strongest neodymium magnets for the ... Free Living developed the Superior Magnetics brand for the ... Free Living performs magnetic therapy using Superior Magnetic Jewelry ...
Breaking Medicine News(10 mins):Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3Health News:Crohn's, Colitis May Have Genetic Underpinnings, Study Finds 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:New Superior Magnetic Necklace Relieves Migraine Headache 2
... -- If you are one of the many people who ... steps can help reduce your stress on Thanksgiving. Mary ... at Binghamton University, State University of New York, offers the ... of time and have a list ready for what you ...
... HealthDay Reporter , TUESDAY, Nov. 23 (HealthDay News) -- ... has spread to the lymph nodes could prevent many unnecessary ... is usually done via a major operation called a thoracotomy. ... operation can remove the cancer. However, if the cancer has ...
... HealthDay Reporter , TUESDAY, Nov. 23 (HealthDay News) -- ... almost 44 percent in those at highest risk for contracting the ... study finds. The reduction in risk climbed to nearly 73 ... percent of the time, the researchers added. Truvada is already ...
... Reinberg HealthDay Reporter , TUESDAY, Nov. 23 (HealthDay ... of the year, many Americans will soon be subjected to ... rising tide of concerns and complaints in recent weeks over ... machines is too low to pose any serious health threat. ...
... (Nov. 23, 2010) Breast cancer stem cells (CSCs), the aggressive ... which promote metastasis, are stimulated by estrogen via a pathway ... were able to halt the expansion of breast CSCs, a ... done in mice, is published in the Proceedings of ...
... -- Ferrography, a practice used by the American and ... extracts tiny iron particles from lubricants such as oil ... a system requires preventative maintenance can be the key ... University scientists are exploring a modification of this technique ...
Cached Medicine News:Health News:Less Invasive Lung Cancer Staging Looks Promising 2Health News:Less Invasive Lung Cancer Staging Looks Promising 3Health News:Daily Pill Lowers Odds for Infection With HIV 2Health News:Daily Pill Lowers Odds for Infection With HIV 3Health News:Daily Pill Lowers Odds for Infection With HIV 4Health News:Airport Body Scanners Safe, Experts Say 2Health News:Airport Body Scanners Safe, Experts Say 3Health News:Discovery halts breast cancer stem cells 2Health News:Monitoring wear in helicopters -- and hips, knees and ankles, too 2Health News:Monitoring wear in helicopters -- and hips, knees and ankles, too 3
(Date:12/19/2014)... 2014 Capnia, Inc. (NASDAQ: ... diagnostics based on its proprietary Sensalyze™ Technology Platform ... financial results for the third quarter and nine ... the completion of our initial public offering (IPO), ... recently initiated CoSense® commercial launch," said Anish Bhatnagar, ...
(Date:12/19/2014)... 18, 2014 Baptist Health Lexington is the first ... receive full Atrial Fibrillation with Electrophysiology Services (EPS) Accreditation status ... Atrial fibrillation is the most common cardiac arrhythmia and has ... can lead to stroke and possible death. More than 5 ... have atrial fibrillation and the numbers are rapidly increasing as ...
(Date:12/19/2014)... Dec. 18, 2014   Aratana Therapeutics, Inc ... company focused on the licensing, development and commercialization ... positive results from its pivotal field study of ... pain in dogs with osteoarthritis.  In the study, ... scores that were statistically significant compared to placebo ...
Breaking Medicine Technology:Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... Nov. 5, 2011 Savient Pharmaceuticals, Inc. (NASDAQ: ... providing further clarity and context surrounding the risk ... occur with KRYSTEXXA® (pegloticase) in the treatment of ... at the American College of Rheumatology (ACR) Annual ...
... Volcano Corporation (NASDAQ: VOLC ), a ... designed to enhance the treatment of coronary and peripheral ... ( AD enosine V asodilator I ndependent ... by Volcano, will be presented in a Late-Breaking Session ...
Cached Medicine Technology:Savient Pharmaceuticals Announces New Data Surrounding KRYSTEXXA® and the Impact of Refractory Chronic Gout at the American College of Rheumatology Meeting 2Savient Pharmaceuticals Announces New Data Surrounding KRYSTEXXA® and the Impact of Refractory Chronic Gout at the American College of Rheumatology Meeting 3Savient Pharmaceuticals Announces New Data Surrounding KRYSTEXXA® and the Impact of Refractory Chronic Gout at the American College of Rheumatology Meeting 4Savient Pharmaceuticals Announces New Data Surrounding KRYSTEXXA® and the Impact of Refractory Chronic Gout at the American College of Rheumatology Meeting 5Savient Pharmaceuticals Announces New Data Surrounding KRYSTEXXA® and the Impact of Refractory Chronic Gout at the American College of Rheumatology Meeting 6Savient Pharmaceuticals Announces New Data Surrounding KRYSTEXXA® and the Impact of Refractory Chronic Gout at the American College of Rheumatology Meeting 7Savient Pharmaceuticals Announces New Data Surrounding KRYSTEXXA® and the Impact of Refractory Chronic Gout at the American College of Rheumatology Meeting 8Volcano Corporation Announces Upcoming Presentation of Late-Breaking Clinical Trial Results and FFR Product Launch at TCT 2011 2Volcano Corporation Announces Upcoming Presentation of Late-Breaking Clinical Trial Results and FFR Product Launch at TCT 2011 3Volcano Corporation Announces Upcoming Presentation of Late-Breaking Clinical Trial Results and FFR Product Launch at TCT 2011 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: