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Adalimumab may reduce health-care costs for Crohn's disease patients
Date:11/12/2008

ee ways: 1) comparing those with 5-ASA use at any time during surveillance to non-users; 2) comparing those whose average dose was > 2 grams/day to those with ≤ 2 grams/day; and 3) calculating the overall effect of 5-ASA use for each 1 gram increase in dose over the course of surveillance. Using this model, no statistically significant chemopreventative effect was demonstrated comparing non-users to any 5-ASA users. However, point estimates slightly favored chemoprevention in the NoD and IND groups.

While the possibility remains that 5-ASA plays a chemopreventative role for CRC in UC, a larger study group is needed to demonstrate such an effect in a statistically significant way, and further studies are required.

UC occurs only in the inner lining of the colon (large intestine) or rectum. Inflammation of the rectum and colon keeps water from being absorbed into the bloodstream and results in diarrhea, abdominal cramps and rectal bleeding. In addition, the risk of colon cancer is higher in UC patients with involvement of the entire colon and in patients who have had the diagnosis for eight to 10 years or more. Patients with a diagnosis of left-sided UC for 15 to 20 years also fall into a higher risk group for developing cancer.


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Contact: Alissa Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

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