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Adalimumab may reduce health-care costs for Crohn's disease patients
Date:11/12/2008

have emphasized that CD patients requiring hospitalization are responsible for the majority of costs. Patients suffering from CD experience pain in the abdomen, often in the lower right side, diarrhea, weight loss and occasional bleeding.

5-ASA's Chemopreventive Role: No Effect

In longstanding patients with ulcerative colitis (UC), study findings failed to show that the use of 5-aminosalicylic acid (5-ASA) demonstrated definitive chemopreventative activity. In addition, those with flat low-grade dysplasia (fLGD) have a higher rate of progression to advanced neoplasia than those with no dysplasia (NoD) or indefinite dysplasia (IND), reports a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute.

"Some studies have suggested that 5-ASA can prevent the development of colorectal cancer (CRC) in UC patients, although none have determined where in the colitis-dysplasia-carcinoma sequence these agents might act," said Thomas A. Ullman, MD, of the Mount Sinai School of Medicine and lead author of the study. "This study not only enabled doctors to address where in this process compounds might exert a chemopreventive effect, but it also allowed them to account for changes in 5-ASA exposure over time, an underappreciated concept in chemopreventive literature."

Three groups of UC patients were identified from an institutional database: 311 NoD patients, 56 with IND and 26 with fLGD. The impact of 5-ASA exposure on the subsequent development of advanced neoplasia (high-grade dysplasia or CRC) was assessed using life-table methods. Of the NoD patients, 17 progressed to advanced neoplasia (seven to CRC). For the IND group, four patients progressed (two to CRC) and 10 fLGD patients progressed (three to CRC).

A proportional hazards analysis was performed on the NoD cohort coding 5-ASA as a time-changing covariate and assessing its impact in thr
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Contact: Alissa Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

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