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Adalimumab may reduce health-care costs for Crohn's disease patients
Date:11/12/2008

t to examine the effect of adalimumab maintenance treatment on both all-cause and CD-related hospitalizations. Of the 778 patients randomized, 260 were assigned to adalimumab every other week, 257 were assigned to adalimumab weekly and 261 received placebo.

Both three- and 12-month hospitalization risks were significantly lower for patients who received adalimumab. In addition, adalimumab every other week and weekly maintenance therapies were associated with 52 percent and 60 percent relative reductions in 12-month, all-cause hospitalization risk, and 48 percent and 64 percent reductions in 12-month risk of CD-related hospitalization.

The combined adalimumab group was associated with 56 percent reductions in both all-cause and CD-related hospitalization risks. Fewer CD-related surgeries occurred in the adalimumab every other week, weekly and combined groups compared with placebo (0.4, 0.8 and 0.6 versus 3.8 per 100 patients, all p<0.05).

"It is important to recognize that CD patients experience comorbidities such as osteoporosis, depression and anxiety disorders, which may improve following successful medical management," said Brian G. Feagan, MD, of the University of Western Ontario and lead author of the study. "Accordingly, the significant decrease in all-cause hospitalization we observed following adalimumab maintenance treatment suggests that therapy may reduce total health-care costs incurred by CD patients. Decreasing the incidence of hospitalization and surgery may be the key to controlling the total health-care burden of CD."

CD is a chronic inflammatory bowel disease that primary affects the small intestine and colon. Because it frequently occurs earlier in life than many other chronic conditions, it imposes a substantial burden. There is remarkable consistency in the literature that hospitalization costs, including surgery, make up 56 percent to 63 percent of the total direct costs. In addition, other economic studies
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Contact: Alissa Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

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