Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs most frequently in people in their late teens and twenties. There have been cases in children as young as two years old and in older adults in their seventies and eighties; men and women have an equal chance of getting the disease.
While the cause(s) of IBD are not known, one theory is based on genetics, indicating that IBD runs in families. About 15 percent to 30 percent of patients with IBD have a relative with the disease. Research is underway to find out if a specific gene or a group of genes makes a person more susceptible to getting the disease. Additionally, many changes in the body's immune system have been discovered in patients with IBD. There is a large amount of research being done in this area as well, including studies to find out if IBD is caused by an infectious agent.
Two recent studies published in Gastroenterology and Clinical Gastroenterology and Hepatology further our understanding of these major illnesses.
Adalimumab Therapy May Provide Important Economic Benefits for Crohn's Disease Patients
Crohn's disease (CD) patients treated with adalimumab have lower one-year risks of hospitalization and surgery, reports a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.
Adalimumab is an anti-tumor necrosis factor (TNF) monoclonal antibody, of human origin, effective for inducing and maintaining clinical response and remission in patients with moderate to severe CD. It is approved for the treatment of CD in North America and Europe.
All data used in these analyses were collected during the Crohn's Trial of the Fully Human Antibody Adalimumab for Remission Maintenance (CHARM) trial, a multi-center, Phase III, double-blind, randomized, placebo-controlled study. This analysis was the firs
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American Gastroenterological Association