Navigation Links
Adalimumab levels detected in cord blood and infants exposed in utero
Date:5/7/2011

Adalimumab (ADA), a drug often prescribed for women with Crohn's disease, actively crosses the placenta during the final trimester of pregnancy and remains in a newborn's bloodstream for at least three months, researchers at the University of California San Francisco have found.

The new study has implications for pregnant women and their obstetricians and pediatricians because ADA is known to decrease the immune system's ability to fight infection. Infants exposed in utero should be monitored closely for infection in the first six months of life and should not receive any live-virus vaccines during that time, cautioned lead researcher Uma Mahadevan, MD.

"Since there is some placental transfer of adalimumab before birth, you have to be vigilant in the first six months of life for the baby," said Dr. Mahadevan, an associate professor of medicine. "However, our findings do not suggest that a pregnant woman should discontinue the drug. Stopping it actually can be more harmful to both baby and mother because of the risk of miscarriage, preterm birth and low birth weight if the Crohn's disease flares."

The study followed five pregnant women with Crohn's disease who were taking ADA. On the day of delivery, ADA levels were measured in the mother, newborn and cord blood. In all cases, the cord blood showed higher levels than the maternal levels indicating transfer from the mother and significant ADA levels were found in three of the newborn samples. Levels continued to be checked in the infants until ADA could no longer be identified.

"At a minimum, it can be detected to three months from birth," Dr. Mahadevan noted.

Dr. Mahadevan said future studies should explore the effects of medications during children's initial years as well as potential risks later in life because of their exposure in utero.

Dr. Mahadevan will present these data on Saturday, May 7 at 4:00 p.m. CT in S404, McCormick Place.


'/>"/>

Contact: Amy Levey
alevey@gymr.com
312-791-6715
Digestive Disease Week
Source:Eurekalert

Page: 1

Related medicine news :

1. Moderate levels of secondhand smoke deliver nicotine to the brain
2. Low Vitamin D Levels Linked to More Aggressive Breast Cancers
3. MRI locates prostate cancer recurrence at extremely low PSA levels
4. Higher Oxygen Levels Improve Preemie Survival: Study
5. Pet Dogs May Be Exposed to High Levels of Flame Retardants
6. Higher levels of social activity decrease the risk of cognitive decline
7. Protein levels could signal that a child will develop diabetes
8. Mexican-American Children Have High Levels of Flame-Retardants in Blood
9. Low Glucose Levels May Raise Death Risk Among Older People
10. Lifestyle Changes Can Slash Blood Fat Levels, Experts Say
11. Research shows blood protein levels may predict risk of a cardiovascular event: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... ... June 25, 2017 , ... CareSet Labs released the Root ... Orleans. This is a new, greatly improved version of the Doctor Referral teaming dataset ... by Fred Trotter and subsequently called the the “Doctor Referral Dataset” as released by ...
(Date:6/24/2017)... York (PRWEB) , ... June 24, 2017 , ... ... the Dental365 family. Located at 217 Portion Road in Lake Ronkonkoma, Dental365 offers ... evenings and weekends so that visits to the dentist fit into their patients’ ...
(Date:6/23/2017)... ... 23, 2017 , ... By scoring 100% for fiscal management and accountability, the ... online charity evaluator, Charity Navigator, validating ANRF's work as a top charity in America. ... Charity Navigator and earns ANRF a spot on their “ 10 Charities Worth Watching ...
(Date:6/23/2017)... ... 2017 , ... Military Connection friend and veteran advocate Micaela Bensko ... Atlantic lounge. , Bensko is no stranger to the plight of the disabled. ... life to supporting our wounded veterans. A world-class photographer, her riveting photos “The Wounds ...
(Date:6/23/2017)... ... 2017 , ... Georgia State University will host the First ... two-day conference is focused on advancing scientific knowledge about the aggressive triple negative ... racial breast cancer-related disparities. The conference theme is “Illuminating Actionable Biology.” , Conference ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 AirXpanders, Inc. (ASX: ... on the design, manufacture, sale and distribution of the ... the progress of its commercial roll-out in ... in more than one hundred (100) medical institutions and ... AeroForm offers a needle-free alternative for women who choose ...
(Date:6/7/2017)... Endo International plc (NASDAQ: ENDP ) today ... R. Goodwin , U.S. District Court Judge for the ... entered a case management order in MDL 2325, American ... (the "MDL") that includes a provision requiring plaintiffs in ... specific causation within one hundred twenty (120) days of ...
(Date:6/3/2017)... , June 3, 2017  Eli Lilly and ... that results from the Phase 3 MONARCH 2 ... & 6 inhibitor, in combination with fulvestrant, significantly ... fulvestrant alone in women with hormone-receptor-positive (HR+), human ... cancer who have relapsed or progressed after endocrine ...
Breaking Medicine Technology: