Navigation Links
Adalimumab levels detected in cord blood and infants exposed in utero
Date:5/7/2011

Adalimumab (ADA), a drug often prescribed for women with Crohn's disease, actively crosses the placenta during the final trimester of pregnancy and remains in a newborn's bloodstream for at least three months, researchers at the University of California San Francisco have found.

The new study has implications for pregnant women and their obstetricians and pediatricians because ADA is known to decrease the immune system's ability to fight infection. Infants exposed in utero should be monitored closely for infection in the first six months of life and should not receive any live-virus vaccines during that time, cautioned lead researcher Uma Mahadevan, MD.

"Since there is some placental transfer of adalimumab before birth, you have to be vigilant in the first six months of life for the baby," said Dr. Mahadevan, an associate professor of medicine. "However, our findings do not suggest that a pregnant woman should discontinue the drug. Stopping it actually can be more harmful to both baby and mother because of the risk of miscarriage, preterm birth and low birth weight if the Crohn's disease flares."

The study followed five pregnant women with Crohn's disease who were taking ADA. On the day of delivery, ADA levels were measured in the mother, newborn and cord blood. In all cases, the cord blood showed higher levels than the maternal levels indicating transfer from the mother and significant ADA levels were found in three of the newborn samples. Levels continued to be checked in the infants until ADA could no longer be identified.

"At a minimum, it can be detected to three months from birth," Dr. Mahadevan noted.

Dr. Mahadevan said future studies should explore the effects of medications during children's initial years as well as potential risks later in life because of their exposure in utero.

Dr. Mahadevan will present these data on Saturday, May 7 at 4:00 p.m. CT in S404, McCormick Place.


'/>"/>

Contact: Amy Levey
alevey@gymr.com
312-791-6715
Digestive Disease Week
Source:Eurekalert

Page: 1

Related medicine news :

1. Moderate levels of secondhand smoke deliver nicotine to the brain
2. Low Vitamin D Levels Linked to More Aggressive Breast Cancers
3. MRI locates prostate cancer recurrence at extremely low PSA levels
4. Higher Oxygen Levels Improve Preemie Survival: Study
5. Pet Dogs May Be Exposed to High Levels of Flame Retardants
6. Higher levels of social activity decrease the risk of cognitive decline
7. Protein levels could signal that a child will develop diabetes
8. Mexican-American Children Have High Levels of Flame-Retardants in Blood
9. Low Glucose Levels May Raise Death Risk Among Older People
10. Lifestyle Changes Can Slash Blood Fat Levels, Experts Say
11. Research shows blood protein levels may predict risk of a cardiovascular event: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Little Rock, AR (PRWEB) , ... October 13, ... ... owned firm with locations throughout Arkansas that offers insurance and financial preparation services, ... to benefit the Rock City Rescue organization. , Rock City Rescue is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: ... data solutions, today announced that its MyDario product is expected to appear ... listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The ... ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, Inc. ... response letter from the U.S. Food and Drug Administration ... of sirukumab for the treatment of moderately to severely ... additional clinical data are needed to further evaluate the ... severely active RA. ...
Breaking Medicine Technology: