Navigation Links
Acute psychological stress promotes skin healing in mice
Date:8/6/2014

Brief, acute psychological stress promoted healing in mouse models of three different types of skin irritations, in a study led by UC San Francisco researchers.

The scientists found that healing was brought about by the anti-inflammatory effects of glucocorticoids steroid hormones produced by the adrenal glands in response to stress.

"Under chronic stress, these same naturally-occurring steroids damage the protective functions of normal skin and inhibit wound healing, but during shorter intervals of stress, they are beneficial for inflammatory disorders and acute injury in both mice and humans," said senior investigator Peter Elias, MD, a UCSF professor of dermatology based at the San Francisco VA Medical Center (SFVAMC).

"We believe that our findings explain why this otherwise harmful component of the stress response has been preserved during human evolution," he said.

The study was published online in the Journal of Investigative Dermatology on August 7, 2014, in advance of print publication in the journal.

The scientists studied mouse models of three types of common skin irritations: irritant contact dermatitis, caused by exposure to an irritant such as a soap or solvent; acute allergic contact dermatitis, of the sort caused by poison ivy or poison oak; and atopic dermatitis, or eczema.

After exposure to irritants on a small patch of skin on one ear, one group of mice was returned to its regular cages, while another group was put in a stressful situation being placed in very small enclosures for 18 hours a day over the course of four days.

The researchers found that the stressed mice showed significantly reduced inflammation and faster healing in all three types of skin irritation.

When stressed mice were simultaneously given mifepristone, which blocks steroid action, all of the healing benefits of stress disappeared. "This demonstrated the central role of internal steroids in providing these benefits," said Elias.

He noted that other researchers have recently proposed that psychological stress has a potential role in promoting healing, "but that work has focused on the immune system rather than glucocorticoids as the responsible, beneficial mediator."

According to Elias, the study provides a clue to an evolutionary puzzle: why, over millions of years, humans have preserved the tendency to produce steroids under stress. Previous research by Elias's laboratory and others has demonstrated that prolonged exposure to steroids harms both the structure and function of skin and other organs.

"Our ancestors did not have an arsenal of pharmaceutical steroids available to treat acute illnesses or injuries," Elias observed. "This safe, effective internal anti-inflammatory system provides just the correct amount of steroids to promote healing, over a time interval that is too short to cause harm."

Elias emphasized that the study did not look at the implications for human medical treatments. However, he contrasted the "substantial benefits" seen from modest increases in glucocorticoid levels brought on by short-term stress with the "adverse effects that we see all too commonly" with steroid therapy. Elias speculated that those negative effects could be the result of "overly aggressive treatment too high doses, and perhaps for unnecessarily prolonged treatment intervals."

He said that while his research team did not study other kinds of inflammatory disorders, "the same benefits of psychological stress should accrue in any acute illness or injury."


'/>"/>

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. Diverticulitis patients reveal psychological, physical symptoms long after acute attacks
2. SWI assesses signal strength in different brain regions after acute hemorrhagic anemia
3. Acute Coronary Syndrome (ACS) Incident Cases to Reach 1.47 million by 2023, Says a New Report Available at ReportsnReports.com
4. GW researchers: Acute kidney injury and chronic kidney disease as interconnected syndromes
5. Citing urgent, acute mental health issues, especially in Africa, experts petition govts to act
6. Negative iron balance predicts acute heart failure survival
7. Moffitt Cancer Centers phase 3 study may be game-changer for acute myeloid leukemia
8. Acute respiratory distress syndrome: Study IDs surgical patients at risk
9. A gene within a gene contributes to the aggressiveness of acute myeloid leukemia
10. Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids
11. New Residential Post-Acute Facility Specializing in Traumatic Brain Injury and Spinal Cord Injury Opens in Mount Dora; Expected to Employ 175
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... certification process to promote standards of excellence for the field of eating disorders, ... March 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ...
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
Breaking Medicine Technology: