Navigation Links
Acute gastric injury due to high-dose analgesics?
Date:12/29/2008

Analgesics, NSAIDs and acetaminophen, are commonly used for the relief of fever, headaches, and other minor aches and pains. The gastrointestinal side effects of NSAIDs are well documented and acetaminophen is accepted to be a safe drug for the gastrointestinal system. Acute effects of short-term, especially high-dose NSAID and acetaminophen use have not been studied adequately.

A research article to be published on November 21 , 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Soylu and her colleagues from Bakirkoy Dr. Sadi Konuk and Dr. Lutfi Kirdar Kartal Research and Training Hospitals in Istanbul investigated the gastrointestinal side effects of high dose acetaminophen and NSAIDs. Acetaminophen and non-steroidal anti-inflammatory drugs are widely used analgesics alone or in combination with other drugs with or without prescription. Acetaminophen is sometimes grouped with NSAIDs; however, it is not an NSAID. Gastrointestinal side effects of NSAIDs at therapeutic doses are well documented. However, acetaminophen is accepted to be free of gastrointestinal side effects at therapeutic doses.

The study group consisted of 50 patients admitted to the emergency department with high dose analgesic ingestion with suicidal intent. Thirty patients with or without mild complaints of dyspepsia were selected as the control group. The study results indicated that gastric lesions were similar between the groups. Thus, acetaminophen is not free of gastrointestinal side effects at high doses.

Dr. Soylu states that this paper is one of the first to document the endoscopic acute gastric damage caused by acute high-dose acetaminophen, but there still remain several questions to be answered. Gastrointestinal side effects of NSAIDs appear within therapeutic doses, but the gastrointestinal side effects of acetaminophen within therapeutic doses still remain to be investigated.

The results of the present paper may be useful in evaluating the gastrointestinal complications of acute high dose analgesic use. Contrary to current convictions, high-dose acetaminophen, as well as NSAIDs, may also cause endoscopic acute gastric damage.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Diabetes appears to increase risk of death for patients with acute coronary syndromes
2. Keane Wins $1 Million Electronic Medical Record (EMR) Implementation at New Jersey-Based Acute Care Facility
3. Study shows insurance status, not race, linked to complications in patients with acute appendicitis
4. FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis
5. Acute lung injury patients one-third less likely to die in closed model ICUs
6. Stereotaxis Highlights New Data on Acute Success in AFib Treatments With Niobe Magnetic Navigation System
7. Short-term hemofiltration is cost-effective for severe acute pancreatitis
8. Baicalin might be a promising therapeutic tool for severe acute pancreatitis
9. Micromet Receives Regulatory Approval to Conduct a Phase 2 Clinical Trial Investigating MT103 (MEDI-538) in Patients with Acute Lymphoblastic Leukemia
10. Renal Solutions, Inc. Announces FDA 510(k) Clearance of New Design of the Allient(R) Sorbent Hemodialysis System for Chronic and Acute Hemodialysis
11. Acute pancreatitis and cholangitis: a complication caused by a migrated gastrostomy tube
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... , ... After a year and a half of planning the Multiple Pathways of Recovery ... Pathways of Recovery Conference was held May 2 -4, 2016 at the Mystic Marriott ... together to explore the many pathways individuals use to get into and sustain their recovery. ...
(Date:5/27/2016)... ... 2016 , ... Two director-level employees of Horizon Blue Cross Blue Shield of ... 2016 honorees. The award recognizes businesswomen who excel in their fields and who ... the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health and Theresa ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... This ... of a stroke, which we as a society can control and change. , As ... occurs nearly every 40 seconds within the United States. Plus, with an estimated 129,000 ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed ... by inspiring human interest stories, courtesy of leaders in the nursing and health ... the industry, from leading advocates and associations—namely Jones & Bartlett Learning. , Jones ...
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting at ... company to wait until March 2017 for an interest rate increase, according to Rajeev ... of Business. , “The Federal Open Market Committee (FOMC) dot charts are of interest ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... CAMBRIDGE, England , May 25, 2016 /PRNewswire/ ... genomics company employing the precision of circulating tumour ... oncology, today announces the appointment of Professor ... will provide medical leadership across the clinical development ... that Inivata,s products help deliver significant improvements in ...
(Date:5/24/2016)... 24, 2016 Cirujanos holandeses han ... a los médicos a compartir sus mejores prácticas por ... mundial. Profesionales médicos de Europa, África, Asia ... a la aplicación, que combina la transmisión en vivo ... seguro. Educación   "Imagine un médico ...
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
Breaking Medicine Technology: