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Active surveillance for low-risk prostate cancer may offer better quality-of-life
Date:11/30/2010

experienced by men under active surveillance. Active surveillance is associated with significant improvements in QALE even in analyses in which the probability of dying of prostate cancer or of developing progressive disease during active surveillance is increased. However, the finding that the optimal strategy is sensitive to utility weights [weight assigned to an individual's preference for a particular health state] is evidence that the decision whether to pursue active surveillance must be individualized. Models that incorporate individual patient utilities should be developed to assist patients and their caregivers to estimate the risks and potential benefits of active surveillance before making this decision," the authors conclude.

(JAMA. 2010;304[21]:2373-2380. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Please Note: For this study, there will be multimedia content available, including the JAMA Report video, embedded and downloadable video, audio files, text, documents, and related links. This content will be available at 3 p.m. CT Tuesday, November 30 at www.digitalnewsrelease.com/?q=jama_3767.

Editorial: Active Surveillance for Prostate Cancer

Ian M. Thompson, M.D., of the University of Texas Health Science Center at San Antonio, Texas, and Laurence Klotz, M.D., of Sunnybrook Health Science Centre, Toronto, write in an accompanying editorial that for the majority of men with favorable-risk localized disease, surveillance will be an attractive option that avoids adverse effects of treatment.

"Ongoing studies to identify biomarkers that are highly specific for indolent tumorsand can effectively id
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Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
JAMA and Archives Journals
Source:Eurekalert

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