Navigation Links
Active surveillance can reduce suffering among men with prostate cancer

With active surveillance many men with prostate cancer could dispense with radiation treatment and surgery, and thus avoid adverse effects such as incontinence and impotence. This is the outcome of a study of almost 1,000 men diagnosed with prostate cancer conducted at Sahlgrenska Academy, University of Gothenburg, Sweden.

The introduction of PSA tests, which are used to screen for prostate cancer, offers early tumour detection, reducing mortality rates. At the same time, prostate cancer is in many cases a slow-growing form of cancer. Many men may never develop symptoms during their lifetime, which means that they are being treated unnecessarily and may be forced to live with serious side-effects such as bowel disorders, urinary incontinence and impotence.

In a study involving 968 men, researchers at Sahlgrenska Academy, University of Gothenburg, found that many prostate cancer sufferers could dispense with treatment and avoid side-effects if they instead opted to undergo active surveillance. This study is a substudy within the major prostate cancer screening trial that has been running in Gothenburg since 1995 under the direction of Jonas Hugosson of Sahlgrenska Academy, University of Gothenburg.

"Active surveillance means monitoring development of the tumour through regular PSA-tests and prostate biopsies. If the tumour shows signs of growth or becomes more aggressive, then the next stage is surgery or radiation treatment. Many men can entirely avoid or at any event postpone the adverse effects associated with curative treatment," says Rebecka Arnsrud Godtman, a doctoral student supervised by Jonas Hugosson.

Of the 968 men with prostate cancer studied, around half (46 per cent) opted for active surveillance as the treatment strategy. The majority of the men had low-risk tumours, but there were also men with intermediate or high-risk tumours.

The results show that:

  • Of the 440 men who chose active surveillance, 60 died, but only one death was the result of prostate cancer.
  • None of the men diagnosed with low-risk tumours developed metastatic prostate cancer or died from the cancer.
  • 63 per cent of the men studied continued with active surveillance for the duration of the follow-up period (up to 15 years).
  • 37 per cent of those who chose active surveillance discontinued this in favour of treatment (surgery, radiation treatment or hormone therapy). The main reason was that surveillance revealed that the tumour had grown.
  • Only four men discontinued active surveillance on the grounds that it made them feel anxious.

  • Active surveillance is more risky for men with intermediate or high-risk tumours. The risk to men with intermediate or high-risk tumours of developing incurable and/or terminal cancer was four times greater than that to men with low-risk tumours.

    "Overall, our results show that active surveillance has the potential to reduce overtreatment, enabling more men to avoid side-effects. A large proportion of the tumours detected through PSA screening are low-risk tumours, and older men in particular could dispense with treatment and instead be monitored safely with active surveillance," says Rebecka Arnsrud Godtman.


    Contact: Rebecka Arnsrud Godtman
    University of Gothenburg

    Related medicine news :

    1. Even physically active women sit too much
    2. Attractive names sustain increased vegetable intake in schools
    3. Human genome far more active than thought
    4. Soy Formula May Harm Babies With Underactive Thyroid: Report
    5. Exergames Can Help Inactive Folks Get Moving: Study
    6. When Parents Get Active, So Do Kids: Study
    7. Interactive personal health records increase clinical preventive services
    8. EliNext Completes Development of a Series of Virtual Reality Interactive 5D Simulation Games on Unity 3D
    9. Friends Life Care, a Pennsylvania Based Long-Term Care Provider, Launches VigR eMeetinghouse — An Interactive Online Community
    10. Author, Speaker Richard London Battles Parkinson’s with an Active Lifestyle and the Desire to Give Back
    11. Active, Outdoor Teens Are Happier Teens: Study
    Post Your Comments:
    (Date:10/13/2015)... ... October 13, 2015 , ... The Lymphoma Research Foundation ... research and serving the lymphoma community through a comprehensive series of education programs, ... Hope; A Commitment to Cure last night at the Mandarin Oriental in New ...
    (Date:10/13/2015)... — , ... ... Association of America (MOAA) will hold its 2015 annual meeting ... a free military career fair; informational seminars; a luncheon featuring ... the Joint Chiefs of Staff; and the Community Heroes Award ...
    (Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... Vision Group ... Vision of San Diego, California. With brands including The LASIK Vision Institute and TLC ... making it the nationwide leader in laser vision correction. , Global Laser Vision will ...
    (Date:10/13/2015)... ... October 13, 2015 , ... PhyMed Healthcare Group , ... its partnership with WPC Healthcare , a provider of predictive analytics solutions ... data into an aggregated data repository necessary to perform reporting and analytics on ...
    (Date:10/13/2015)... Texas (PRWEB) , ... October 13, 2015 , ... Symposium ... for the 19th annual Dallas Cosmetic Symposium to be held March 2nd and 3rd, ... place immediately afterwards, draws plastic surgeons and cosmetic physicians from around the world. , ...
    Breaking Medicine News(10 mins):
    (Date:10/13/2015)... 2015   Vigilant Biosciences, Inc. ("Vigilant"), a ... the early detection and intervention of cancer, announced today ... CEO, Matthew H.J. Kim , the Weaver H. ... entrepreneur who has made extraordinary contributions to the growth ... in the leadership of a company or institution. ...
    (Date:10/13/2015)... Oct. 13, 2015 WuXi PharmaTech (Cayman) ... technology platform company serving the pharmaceutical, biotechnology, and ... launched a mobile version of OncoWuXi, the first ... access oncology models and data on the go.  ... at any time to identify relevant tumor models ...
    (Date:10/13/2015)... , Oct. 13, 2015   Happy ... direct-to-consumer laboratory home testing kit for breast ... technologies provide an unparalleled, detailed assessment of ... milk—fats, proteins, carbs and key vitamins—all charted ... for personal health tracking.  In addition, Happy Vitals ...
    Breaking Medicine Technology: