Navigation Links
Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer
Date:12/12/2007

A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation of cancerous cells.

Over the past 3-4 decades much scientific research has dealt with the medicinal properties of different fungi. One of the important characteristics of fungi is the ability to fight cancer in a number of ways; however most of the research has been concentrated on how fungi affect the immune system. In this research, conducted by Dr. Ben-Zion Zaidman, under the direction of Prof. Eviatar Nevo and Prof. Solomon Wasser from the Institute of Evolution at the University of Haifa, and Dr. Jamal Mahajna from the Migal Galilee Technology Center, the researchers examined how fungi fight cancer from within cells. "Up to now, research has been based on enhancing the immune system with high-molecular-weight polysaccharides that act through specific receptors in cell membranes. We concentrated our research on low-molecular-weight secondary metabolites that can penetrate the cells and act at the molecular level from within the cell itself," explained Dr. Zaidman.

According to Dr. Zaidman, prostate cancer, one of the most common cancers found among men in the Western World, is controlled by the androgen receptor, especially at the initial stages of development of the disease. Therefore, all of the current medications used to treat prostate cancer work to reduce the production of androgens or to interfere with their function via the androgen receptor.

At the first stage of the research, 201 organic extracts from 68 types of fungi were produced with solvents such as ether, ethyl acetate and ethanol. These solvents are used to select molecules that are small enough to act from within the cells. Of the 201 extracts, 11 were found to deter androgen receptor activity by more than 40%. In further testing, 169 extracts were tested for cancer cell growth inhibition. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From among the active extracts, those from Ganoderma lucidum were found to be the most effective in inhibiting the function of the androgen receptor and controlling vital development of cancerous cells. "The results of this research are particularly interesting from a commercial aspect. Potential possibilities exist to establish research and development of bioactive metabolites from Ganoderma lucidum that could yield an anti-prostate cancer drug," remarked Dr. Zaidman.


'/>"/>

Contact: Dr. Amir Gilat
agilat@univ.haifa.ac.il
972-482-40092
University of Haifa
Source:Eurekalert

Related medicine news :

1. Many Older Americans Have Active Sex Lives
2. More than two-thirds of sexually active NYC youth use condoms, but other forms of birth control lag
3. Schwablearning.Org Launches Interactive Tool to Help Parents of Children Struggling in School
4. Human C-reactive protein regulates myeloma tumor cell growth and survival
5. National Movement Disorders Interactive Experience Center Comes to Tampa Bay for First Time
6. Figure Skater Peggy Fleming Teams with HealthSaver: Raise Healthy Children Through Active Parenting
7. A New Interactive Consumer Experience Highlighting Successful Weight Loss Strategies is Coming to a Mall Near You
8. PDL BioPharma to Actively Seek Sale of Entire Company or Its Key Assets
9. Strawberry Consumption Associated with C-Reactive Protein Among Women: New Harvard Study
10. Mayo Clinic Proceedings: Men with chronic heart failure can have active sex lives
11. Overweight mothers run greater risk of having hyperactive children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ATLANTA, Ga. (PRWEB) , ... July 27, 2017 , ... ... Man native Sam Brand to the men’s pro squad as a stagiaire for the ... to make his professional debut on July 31st at the Tour of Utah. , ...
(Date:7/26/2017)... ... ... Capillus, LLC has announced the redesign of their FDA-cleared low-level laser (light) ... a more comfortable, adaptable fit and is available for purchase immediately. , Carlos ... therapy caps intended to improve both user experience and hair regrowth. , “Our ...
(Date:7/26/2017)... Ca (PRWEB) , ... July 26, 2017 , ... A ... lyophilization processes. Inconsistent results freeze drying samples and a lengthy freeze dry cycle are ... webinar will discuss freeze drying techniques, as well as new accessories and advancements in ...
(Date:7/26/2017)... ... , ... It's time to sign up for the new One-A-Month Essential Oil Club ... founder of Sublime Naturals and author of numerous books on essential oils. , ... the 5th. , Two items are included in the December mailing. , ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... and cats has opened in Jupiter. The state of the art center ... class leading treatments with a goal of providing heart patients longer lives. , ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... LOVELAND, Colo. , July 26, 2017 ... Tristan Guttridge and the Bimini SharkLab to custom design the ... diagnostic images of sharks in their native habitat. In ... for Discovery Channel,s Shark Week, Dr. Guttridge approached ... to take pregnancy diagnosis directly to hammerhead sharks underwater. ...
(Date:7/26/2017)... July 26, 2017 The Galien Foundation ... USA Award Nominees. Counted among the ... Award recognizes outstanding biomedical and technology product achievement that improves ... To qualify, each candidate must be U.S. Food and Drug ... and demonstrate tremendous potential to impact human health. Sales data ...
(Date:7/24/2017)... , July 24, 2017 IBM (NYSE: IBM ... Magic Quadrant for Solid-State Arrays (SSA) for the fourth year ... According to Gartner, "Vendors in the Leaders quadrant have ... of Vision. A vendor in the Leaders quadrant has the ... drive the acceptance of new technologies. These vendors demonstrate a ...
Breaking Medicine Technology: