Navigation Links
Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer

A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation of cancerous cells.

Over the past 3-4 decades much scientific research has dealt with the medicinal properties of different fungi. One of the important characteristics of fungi is the ability to fight cancer in a number of ways; however most of the research has been concentrated on how fungi affect the immune system. In this research, conducted by Dr. Ben-Zion Zaidman, under the direction of Prof. Eviatar Nevo and Prof. Solomon Wasser from the Institute of Evolution at the University of Haifa, and Dr. Jamal Mahajna from the Migal Galilee Technology Center, the researchers examined how fungi fight cancer from within cells. "Up to now, research has been based on enhancing the immune system with high-molecular-weight polysaccharides that act through specific receptors in cell membranes. We concentrated our research on low-molecular-weight secondary metabolites that can penetrate the cells and act at the molecular level from within the cell itself," explained Dr. Zaidman.

According to Dr. Zaidman, prostate cancer, one of the most common cancers found among men in the Western World, is controlled by the androgen receptor, especially at the initial stages of development of the disease. Therefore, all of the current medications used to treat prostate cancer work to reduce the production of androgens or to interfere with their function via the androgen receptor.

At the first stage of the research, 201 organic extracts from 68 types of fungi were produced with solvents such as ether, ethyl acetate and ethanol. These solvents are used to select molecules that are small enough to act from within the cells. Of the 201 extracts, 11 were found to deter androgen receptor activity by more than 40%. In further testing, 169 extracts were tested for cancer cell growth inhibition. In this study, 14 extracts were found to be active in inhibiting prostate cancer cells.

From among the active extracts, those from Ganoderma lucidum were found to be the most effective in inhibiting the function of the androgen receptor and controlling vital development of cancerous cells. "The results of this research are particularly interesting from a commercial aspect. Potential possibilities exist to establish research and development of bioactive metabolites from Ganoderma lucidum that could yield an anti-prostate cancer drug," remarked Dr. Zaidman.


Contact: Dr. Amir Gilat
University of Haifa

Related medicine news :

1. Many Older Americans Have Active Sex Lives
2. More than two-thirds of sexually active NYC youth use condoms, but other forms of birth control lag
3. Schwablearning.Org Launches Interactive Tool to Help Parents of Children Struggling in School
4. Human C-reactive protein regulates myeloma tumor cell growth and survival
5. National Movement Disorders Interactive Experience Center Comes to Tampa Bay for First Time
6. Figure Skater Peggy Fleming Teams with HealthSaver: Raise Healthy Children Through Active Parenting
7. A New Interactive Consumer Experience Highlighting Successful Weight Loss Strategies is Coming to a Mall Near You
8. PDL BioPharma to Actively Seek Sale of Entire Company or Its Key Assets
9. Strawberry Consumption Associated with C-Reactive Protein Among Women: New Harvard Study
10. Mayo Clinic Proceedings: Men with chronic heart failure can have active sex lives
11. Overweight mothers run greater risk of having hyperactive children
Post Your Comments:
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... A team ... ways to treat it. Surviving Mesothelioma has just posted the findings on the ... University Hospital Zurich analyzed the cases of 136 mesothelioma patients who were treated with ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion ... Cut Pro X. With ProSidebar: Fasion, video editors can easily add an informative ... a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, and ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment you ... for not only fulfilling the needs of advisers and clients but going above ... and providing top-tier customer service. However, there's always room for improvement, which is ...
(Date:11/27/2015)... San Francisco, California (PRWEB) , ... November 27, 2015 , ... ... 1969 Janis Joplin Ann Arbor Michigan boxing style concert posters. This is one of ... 1969 at the Canterbury House at the University of Michigan in Ann Arbor. The ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... Representative. As a franchise owner, Somu now offers travelers, value and care based ... packages, private cruise sales, as well as, cabin upgrades and special amenities such ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Research and Markets ( ) has ... Market 2015-2019" report to their offering. ... report, the author the present scenario and growth prospects ... calculate the market size, the report considers revenue generated ... IUDs and copper IUDs. The report forecasts the global ...
(Date:11/26/2015)... Países Bajos, November 26, 2015 ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... con la terapia fotodinámica de Bremachlorin para el cáncer ... enfoque combina la inmunoterapia con la terapia fotodinámica de ... Clinical Cancer Research . --> Clinical Cancer ...
(Date:11/26/2015)... Nederland, November 26, 2015 ... Een nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische ... ) --> ...      (Photo: ) ... Universitair Medisch Centrum (LUMC) blijkt ...
Breaking Medicine Technology: