Navigation Links
Active component of grape seed extract effective against cancer cells
Date:12/4/2013

A University of Colorado Cancer Center study published online ahead of print in the journal Nutrition and Cancer describes the laboratory synthesis of the most active component of grape seed extract, B2G2, and shows this synthesized compound induces the cell death known as apoptosis in prostate cancer cells while leaving healthy cells unharmed.

"We've shown similar anti-cancer activity in the past with grape seed extract (GSE), but now we know B2G2 is its most biologically active ingredient which can be synthesized in quantities that will allow us to study the detailed death mechanism in cancer cells," says Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences. Tyagi works in the lab of CU Cancer Center investigator and Skaggs School of Pharmacy faculty member, Chapla Agarwal, PhD.

The group has spent more than a decade demonstrating the anti-cancer activity of GSE in controlled, laboratory conditions. For example, previous studies have shown the GSE effectiveness against cancer cells and have also shown its mechanism of action. "But until recently, we didn't know which constituent of GSE created this effect. This naturally occurring compound, GSE, is a complex mixture of polyphenols and also so far it has been unclear about the biologically active constituents of GSE against cancer cells," Tyagi says.

Eventually the group pinpointed B2G2 as the most active compound, but, "it's expensive and it takes a long time to isolate B2G2 from grape seed extract," Tyagi says.

This expense related to the isolation of B2G2 has limited the group's further exploration. So instead of purifying B2G2 from GSE, the group decided to synthesize it in the lab. The current study reports the success of this effort, including the ability to synthesize gram-quantity of B2G2 reasonably quickly and inexpensively.

In the paper's second half, the group shows anti-cancer activity of synthesize
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. 62 percent of men and 37 percent of women over the age of 65 are sexually active
2. Gene Signal presents data at ARVO 2012 showing topical aganirsen is active in retinal disease
3. Introducing Screenplay: An interactive childrens waiting room experience
4. Inherited DNA change explains overactive leukemia gene
5. Key to More Active, Slimmer Kids: Friends
6. New anti-inflammatory drugs pinch off reactive oxygen species at the source
7. Parents - not TV - may determine whether kids are active or couch potatoes
8. SingleSource Background Screening Company Calls On Adults To Take Proactive Approach To Stop Child Sexual Abuse
9. Active, Outdoor Teens Are Happier Teens: Study
10. Author, Speaker Richard London Battles Parkinson’s with an Active Lifestyle and the Desire to Give Back
11. Friends Life Care, a Pennsylvania Based Long-Term Care Provider, Launches VigR eMeetinghouse — An Interactive Online Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... (PRWEB) December 26, 2014 Yisrayl Hawkins, Pastor ... an open letter in light of the Ferguson, Missouri unrest. ... of civil unrest and explains why it has only increased. ... mankind was even created. He says there is a very ... Yisrayl also says there is a set of rules, or ...
(Date:12/26/2014)... Pentec Health, Inc. number fourteen on the ... for 2014. The awards program, created in 2000, is ... in the country. The program is a public/private partnership ... and Economic Development, the Pennsylvania State Council of the ... Business Journal. , Charlie Wilson, Vice President ...
(Date:12/25/2014)... December 26, 2014 The ... combines beauty, strength and durability. Today, the business ... which is valid until Jan. 30, 2015. , ... of traditional hardwood. BambooFlooringChina.com is a well-known brand ... consumers worldwide to find a reliable bamboo flooring ...
(Date:12/25/2014)... 2014 Recently, iFitDress.com, the popular online supplier ... announced its new selection of black one-shoulder cocktail dresses ... now; they are available at discounted prices, up to 70% ... will last for three weeks only. You know, we have ... are interested in our new items can visit our website ...
(Date:12/25/2014)... December 25, 2014 Helen Harris’ RP ... Woodland Hills, California after an 8 year battle with ... Christmas Eve evening in her home in Woodland Hills ... breast cancer. , As the founder ... years, she pioneered and championed many of today's greatest ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... to educate Americans about their risk of type 2 diabetesPORT ... Alert(R) Day. The American Diabetes Association urges all Americans ... have it. To help educate the public, the American ... Medical Supply, Inc., have teamed up to provide an online ...
... changes. , ... Milwaukee, WI (Vocus) ... provider of Individual Medical, Small Group and Specialty health insurance ... they face economic hardship., , , , ,“In these challenging ...
... Option for Adult Patients Suffering From Community-Acquired Bacterial ... a division of Wyeth (NYSE: WYE ... Drug Administration (FDA) approved TYGACIL(R) (tigecycline), for the ... (CABP) caused by susceptible strains of indicated pathogens. ...
... is too strictly controlled, study finds , , TUESDAY, March 24 ... or ICUs, often experience spikes in blood sugar, and current ... a new study found that this strategy might actually boost ... "Intensively lowering blood glucose in critically ill patients is not ...
... Victoria,s Secret Fashion Show and Armani Exchange model to ... cureHOLLYWOOD, Fla., March 24 Brazilian supermodel Izabel Goulart ... for the Diabetes Research Institute Foundation, the nonprofit organization ... the world-renowned Diabetes Research Institute (DRI) at the ...
... alcoholism, abuse and unwanted pregnancies are quite common and ... Marie-Dominique Beaulieu, a professor at the Universit de Montral,s ... my practice," says Beaulieu, who also holds the Dr. ... to feelings of guilt, anger and helplessness. These feelings ...
Cached Medicine News:Health News:American Diabetes Association Alert(R) Day Video - Do You Have Diabetes? 2Health News:American Diabetes Association Alert(R) Day Video - Do You Have Diabetes? 3Health News:American Diabetes Association Alert(R) Day Video - Do You Have Diabetes? 4Health News:Assurant Health Helps People Keep Their Insurance 2Health News:Assurant Health Helps People Keep Their Insurance 3Health News:FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia 2Health News:FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia 3Health News:FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia 4Health News:FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia 5Health News:FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia 6Health News:FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia 7Health News:Tight Blood Sugar Control May Raise Risks in the ICU 2Health News:Tight Blood Sugar Control May Raise Risks in the ICU 3Health News:Tight Blood Sugar Control May Raise Risks in the ICU 4Health News:Supermodel Izabel Goulart Partners With Diabetes Research Institute Foundation as International Ambassador 2Health News:Supermodel Izabel Goulart Partners With Diabetes Research Institute Foundation as International Ambassador 3
(Date:12/24/2014)... and FARMINGTON, Conn. , ... (NYSE MKT: PTN), a biopharmaceutical company developing targeted, ... with significant unmet medical need and commercial potential, ... private placement of 2,050,000 shares of its common ... shares of its common stock.  Funds under the ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
(Date:12/24/2014)... , December 24, 2014 ... Report on Global Disposable Syringe Industry of ... its online business intelligence library. ... Disposable Syringe Industry is a professional and ... market.  For overview analysis, the report introduces ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5
... CHAPEL HILL, N.C., Dec. 17, 2010 The oncology ... by many organizations in the bio-pharmaceutical sector. It,s in ... are scrutinizing their strategies and tactics to support market ... successful launch, it,s critical that companies inform thought leaders, ...
... the growing cholera epidemic in Haiti, the American Red ... the Pan American Health Organization (PAHO) to purchase, ship, ... (Logo: http://photos.prnewswire.com/prnh/20090108/RedCrossLOGO ) ... in Haiti has now exceeded 100,000. Funds will provide ...
Cached Medicine Technology:Research from Best Practices, LLC Delivers Effective Market Education Tactics and Strategies for New Oncology Products 2Red Cross Supports Pan American Health Organization with $1.5 Million in Medicine and Supplies for Cholera Response 2
Weighing just two ounces, this durable, self-contained unit delivers an accurate pulse rate and bloodoximetry in just seconds....
The SportStat Pulse Oximeter shines red and infrared light through a finger and detects the fluctuating signals caused by blood flow. Pulse rate is determined from the signals received by a light det...
The FetalSAT™ System with DualSens Sensor displays continuous, real-time fetal pulse oximetry (FSpO2) and fetal pulse rate (FPR) values in one compact monitor....
The OX-2 is configured asstandalone or handheld unit, designed for hospital, transport and home use....
Medicine Products: