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Active Smoking Can Worsen Response to Treatment in Patients With Metastatic Kidney Cancer
Date:12/5/2013

Durham, NC (PRWEB) December 05, 2013

A recent study featured in the latest issue of The Oncologist shows that active smoking greatly diminishes patients’ chances of responding to chemotherapeutic treatment for renal cell carcinoma (RCC). The research team, jointly led by Dr. Michael Carducci from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD and Dr. Daniel Keizman from the Sackler School of Medicine at Tel Aviv University, conducted a retrospective analysis exploring the association of various risk factors for RCC with patient response rate and survival following sunitinib treatment.

RCC is the most common type of malignancy of the kidney and the tenth most common cause of cancer-related death among men in the US. Approximately 30% of patients with RCC present with metastases, and 40% of those treated for a localized tumor eventually show recurrence. Sunitinib, a vascular endothelial growth factor (VEGF)-targeting drug, is widely used as a first-line treatment for this disease; however, its efficacy is limited, and tumors will often progress post treatment.

The researchers utilized data from 278 metastatic RCC patients who had undergone sunitinib treatment at 7 different institutions in the US and Israel and assessed known risk factors for the disease, including smoking, obesity, and diabetes, all of which have been associated with poor therapeutic outcome in various cancers. Concordant with RCC epidemiology, the median age of the participants was 63 and about two-thirds of them were men. While about half of the patients were never smokers, more than 20% were active smokers, and the remainder had some history of smoking. Nearly a quarter of the patients were obese, more than a quarter were diabetic, and more than half of them had hypertension prior to sunitinib treatment.

After a median follow-up period of 55 months, imaging evaluations revealed a complete response in 3% o
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