Navigation Links
Activation of the prefrontal cortex improves working memory

This release is available in Spanish.

Psychologists and neurologists invest considerable effort in the study of working memory. In terms of information retention, there is a difference between long-term memory, which is affected in diseases such as Alzheimer, and short-term or working memory, which allows us to make immediate decisions or structure a discourse. This more ephemeral memory is affected in diseases such as schizophrenia and depression, although a cause-effect relationship has not been established. People with a higher working-memory capacity score higher on intelligence tests and, for this reason, it is thought that it may be intimately linked to people's cognitive ability. A study by IDIBAPS uses computational systems neurobiology models and functional magnetic resonance imaging scans to show that there are two parts of the cerebral cortex with highly differentiated roles implicated in this type of memory. The results of the study were published in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS), in an article headed by Dr. Albert Compte of the Systems Neuroscience team of the Institut d'Investigacions Biomdiques August Pi i Sunyer (IDIBAPS), and with Fredrik Edin as the first author. This study was carried out in collaboration with two other laboratories of the Karolinska Institute, Stockholm, led by professors Torkel Klingberg and Jesper Tegnr.

Thanks to complex computer algorithms, it is possible to simulate a virtual network in which a large number of neurons interact. These models can simulate the functioning of the structures in our brains. According to the computer model published in PNAS, when the working memory needs to be increased, the prefrontal cortex reinforces the activation of the parietal cortex, in which the information is temporarily stored. A brief stimulus that reaches the parietal cortex generates a reverberating activation that maintains a subpopulation active, while inhibitory interactions with neurons further away (lateral inhibition) prevents activation of the entire network. This lateral inhibition is also responsible for limiting the mnemonic capacity of the parietal network. The reinforcement of the parietal cortex by the prefrontal cortex prevents its inhibition, thereby temporarily improving working memory.

To verify this hypothesis, 25 healthy individuals carried out simple visual-memory tests while inside a functional magnetic resonance scanner. The differences in their ability to complete the exercises were linked to the intensity of activation of the prefrontal cortex and to their interconnection with the parietal cortex. The IDIBAPS and Karolinska researchers thus confirmed the hypothesis formulated based on the computer model. The more the prefrontal cortex is activated, the greater the capacity of the parietal cortex for retaining short-term visual information - an indicator of working-memory capacity.

This study explains many diverse results that have been obtained in recent years in psychology and neuroimaging studies on working memory. This is an innovative view of the neurobiological mechanisms of cognitive control and opens up new lines of research. Clinical studies will be needed to determine whether the stimulus of the prefrontal cortex, or its training by means of memory exercises and games, can have an effect on diseases in which working memory is damaged, such as depression or schizophrenia.


Contact: Alex Argemi
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer

Related medicine news :

1. Pedophilia patients are found to have deficits in brain activation
2. MedCom USAs Subsidiary Card Activation Technologies, Inc.s SB2 Registration Declared Effective by SEC
3. MedCom Announces Court Rules Card Activation Technologies Patent Is Valid
4. MedCom Announces Card Activation Wins Significant Court Ruling
5. Sysmex America to Enable Prolonged Hematology Instrument Uptime for Hagerstown Medical Laboratory With 1,000th SNCS Activation
6. Activation of LYN kinase is associated with imatinib-resistance in CML patients
7. Wellcorps International Releases Breakthrough Multi-Benefit WellCapAM(TM) Activation Complex
8. Wesley Mosley Selected to Participate in Global Youth Activation Summit During the 2009 Special Olympics World Winter Games
9. LifeMasters Introduces Health Activation Tool to Disease Management Participants
10. In jazz improv, large portion of brains prefrontal region takes 5 to let creativity flow
11. Selective attention increases both gain and feature selectivity of the human auditory cortex
Post Your Comments:
(Date:10/12/2015)... ... October 12, 2015 , ... To help ... its charitable donation to the National Breast Cancer Foundation. The National Breast Cancer ... breast cancer through early detection, education, and support services. , The annual campaign ...
(Date:10/12/2015)... ... October 12, 2015 , ... SQM Group ... a contact channel benchmarking study. Be a part of this insightful ... for improving customer experience, customer journey, contact channel execution and intelligence, workforce optimization, ...
(Date:10/12/2015)... ... ... Holcomb – Kreithen Plastic Surgery and MedSpa, PLLC (“Holcomb – Kreithen”), one of ... Surgery University,” an educational series of mini seminars covering aesthetic and plastic surgery options, ... Saturday, October 24, 2015. , The goal of the event is to provide hands-on ...
(Date:10/12/2015)... ... October 12, 2015 , ... The Asthma and ... Engagement Award by the Patient-Centered Outcomes Research Institute (PCORI) for a new project ... , The project, entitled “Training Patients with Asthma to Understand and Participate in ...
(Date:10/12/2015)... ... October 12, 2015 , ... International law firm Greenberg ... with the U.S. Biomedical Advanced Research and Development Authority (BARDA) reported to be ... ReCell® Autologous Cell Harvesting Device under a U.S. mass casualty preparedness program. ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... New York , October 12, 2015 ... (FMI) delivers key insights on the global vital signs monitoring ... Devices Market: Global Industry Analysis and Opportunity Assessment 2015-2025." The ... at a healthy CAGR of 9.5% and 9.2% in terms ... to factors, regarding which FMI offers major insights in detail ...
(Date:10/12/2015)... Oct. 12, 2015 Beginning October 1, 2015 ... Partner, the fastest growing practice management system for therapists, ... easily converts all patient diagnostic codes from the former ... --> --> Therapy Partner has ... mental health practitioners to easily understand the conversion to ...
(Date:10/12/2015)... , Oct. 12, 2015 Indivior PLC (LON: INDV) ... of Delaware granted the Company,s motion ... Abbreviated New Drug Application (ANDA) No. 205299 to market a ... and naloxone) Sublingual Film (CIII) in the United ... Since August 2013, Indivior has received Paragraph IV certifications ...
Breaking Medicine Technology: