Navigation Links
Acologix AC-200 Demonstrates Positive Effect on Bone in Preclinical Model of Chronic Kidney Disease
Date:11/7/2008

Data Presented at the 41st Annual Meeting of the American Society of

Nephrology

HAYWARD, Calif., Nov. 7 /PRNewswire-FirstCall/ -- Acologix, Inc., a privately held biopharmaceutical company, will present data indicating that its therapeutic product candidate AC-200 improved bone architecture in a rat model of chronic kidney disease. AC-200, an endogenous human protein produced by bone cells, was evaluated in a well accepted rodent model of chronic kidney disease (CKD) in which bone loss is rapid and substantial. The data will be presented by David Rosen, Ph.D on November 8, 2008 at the 41st ASN (American Society of Nephrology) Annual Meeting in Philadelphia, PA.

The effects of AC-200 on bone and mineral metabolism were evaluated in partially nephrectomized rats (5/6 Nx). These rats have reduced renal function which leads to elevated levels of serum phosphate and parathyroid hormone (PTH). Bone loss is an important feature of the model, similar to renal osteodystrophy seen in CKD patients. Recombinant AC-200 (MEPE: Matrix Extracellular Phosphoglycoprotein) or vehicle control were administered for 14 days by intravenous injections to 5/6 Nx rats. Serum and urine biochemistry assays were performed to determine the effects on renal function and mineral metabolism. Femurs were analyzed by X-ray and histology to determine effects on both cortical and trabecular bone.

AC-200 administration resulted in marked reductions in serum phosphorus and PTH levels compared to those in vehicle treated controls. The vehicle treated 5/6Nx group showed the expected changes in bone architecture due to the loss of kidney function, such as thinner trabecular bone in the metaphysis, increased cortical bone resorption and increased fibrosis in the marrow space. In contrast, in rats administered AC-200, bone architecture resembled that of sham operated controls. These data suggest that AC-200 offers a unique dual benefit in CKD, pot
'/>"/>

SOURCE Acologix, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Dawn McGuire, M.D. Joins Acologix, Inc. as Chief Medical Officer
2. New Study Demonstrates Cost Effectiveness of NeuroStar TMS Therapy(R) in the Treatment of Depression
3. WVU study demonstrates efficacy of CT perfusion in diagnosis of acute ischemic stroke
4. David B. Samadi, MD, Demonstrates Robotic Prostate Surgery During Live Webcast, August 13, 2008
5. New CDC Report Demonstrates Urgency for All States and Cities to Become Smokefree
6. New Survey Demonstrates Increased Awareness of the Dangers of Meth Use
7. Data from Pooled Analyses Demonstrates Welchol, Combined with Metformin- or Sulfonylurea-Based Therapy, Significantly Lowers Blood Glucose in Adults with Type 2 Diabetes
8. Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals
9. MEDai Demonstrates the Value of Implementing Predictive Analytics
10. NEJM study demonstrates carotid stenting with embolic protection is comparable to surgery
11. Siemens Demonstrates New Version of Multimodality Cardiology Image Management Solution at ACC 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Gwyneth Paltrow, Beyonce and Angelina Jolie are only ... dieters all over the United States, to find the best ... them quickly shed excess fat. And, recent inspiration has come ... all gluten products, eggs and meats for ingredients like goji ... following this type of diet, one must be a celebrity ...
(Date:8/29/2014)... August 29, 2014 Edvance360, a leading ... tools for online teaching, as well as 2011 winner ... or Learning Management System, announced that their CTO, Brian ... in the ALS Ice Bucket Challenge on behalf of ... Sanders, Edvance360 Co-Founder. , “We know that the options ...
(Date:8/29/2014)... NC (PRWEB) August 29, 2014 In ... of physicians retiring, merging or selling their practices. The ... physicians are likely to retire earlier than planned in ... survey, most U.S physicians are concerned about the future ... healthcare market. In general, physicians are cynical and worried ...
(Date:8/29/2014)... 29, 2014 Hope For The Warriors® ... Spouse/Caregiver Scholarships. Scholarships are awarded two times each year ... to spouses of fallen service members. Hope For The ... sense of self, restoring the family unit, and restoring ... , The Spouse/Caregiver Scholarship Program identifies, recognizes, and ...
(Date:8/29/2014)... Cincinnati, OH (PRWEB) August 29, 2014 Today, ... in the country with not only a healthcare network ... , “We started the network a few weeks ... every state,” said Michael Lee of Progene. , The ... get to take care of our customers before and after ...
Breaking Medicine News(10 mins):Health News:Diet Doc Announces Diet Plans that Deliver Fast Weight Loss Results at a Fraction of the Cost of Celebrity Diets 2Health News:Diet Doc Announces Diet Plans that Deliver Fast Weight Loss Results at a Fraction of the Cost of Celebrity Diets 3Health News:Edvance360 Participates In the ALS Ice Bucket Challenge (#ALSicebucketchallenge) 2Health News:Planning for Retiring, Selling, or Closing Down the Practice? Help is at Hand 2Health News:Planning for Retiring, Selling, or Closing Down the Practice? Help is at Hand 3Health News:Planning for Retiring, Selling, or Closing Down the Practice? Help is at Hand 4Health News:Hope For The Warriors Announces Fall 2014 Spouse/Caregiver Scholarship Recipients 2Health News:Hope For The Warriors Announces Fall 2014 Spouse/Caregiver Scholarship Recipients 3Health News:Progene Is Doctor Recommended Nationwide 2Health News:Progene Is Doctor Recommended Nationwide 3
... Ky., Dec. 23 A group representing some of the ... drop language that would require vending companies to disclose the ... the point of sale, Vend Marketing Institute (VMI) Executive Director ... both the House and Senate versions of the healthcare reform ...
... for King Herod Himself , WASHINGTON, Dec. 23 As ... Reid,s health care bill, Family Research Council Action (FRC Action) ... call campaign in six states -- Nebraska, Arkansas, Louisiana, South ... to contact their Senators and tell them "don,t trade the ...
... Female janitors, scientists among those at highest risk, study ... working women in the United States, teachers seem to ... defects, while those who work as janitors, scientists and ... The study looked at nearly 9,000 babies born with ...
... ... conference provides First Responders with professional education and networking opportunity. , ... (PRWEB) December 23, ... Responders with professional education and networking opportunity., , ,Against a background of threats ...
... ... provider, today announced the appointment of a new leader who will help expand its ... ... debate rages on all sides of healthcare reform, one fact remains: the heavy lifting ...
... A McMaster University researcher has found the first evidence ... in car exhaust fumes and industrial air pollution can lead ... Infectious disease specialist Mark Loeb led a research team ... and sulfur dioxide, both found in motor vehicle emissions, and ...
Cached Medicine News:Health News:Vend Marketing Institute Calls on Congress to Modify Calorie Disclosure Requirement: Supports Existing Disclosure Which Is More Complete and Effective 2Health News:Vend Marketing Institute Calls on Congress to Modify Calorie Disclosure Requirement: Supports Existing Disclosure Which Is More Complete and Effective 3Health News:FRC Action Launches Last Minute Phone Call Campaign in Six States 2Health News:Mom's Job Could Boost Baby's Odds for Birth Defect 2Health News:5th Annual Homeland Security Professionals Conference and Exposition in Vegas on October 25-29 2010 2Health News:5th Annual Homeland Security Professionals Conference and Exposition in Vegas on October 25-29 2010 3Health News:New Executive Director to Lead Medical Education to Greater Relevance 2Health News:Air pollution linked to hospitalizations for pneumonia in seniors 2
(Date:8/28/2014)... Mass. , Aug. 28, 2014  Seres ... for diseases related to the human microbiome, announced ... Executive Vice President of R&D and Chief Scientific ... Conference on Antimicrobial Agents and Chemotherapy (ICAAC). The ... of SER-109, a novel mixture of bacterial spores ...
(Date:8/28/2014)... 28, 2014 Reportlinker.com announces ... is available in its catalogue: ... Markets to 2020 - Novel Therapeutic ... Newly Diagnosed and Recurrent GBM ... Glioblastoma Multiforme Therapeutics in ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 ... new market research report is available ... Therapeutics to 2020 - Broadened Diagnostic ... Drive Market Growth despite Patent Expirations ... ADHD Therapeutics to 2020 ...
Breaking Medicine Technology:Seres Health to Present Clinical Findings at ICAAC 2014 Conference 2Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 2Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 3Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 4Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 5Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 6Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 7Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 8Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 9ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 2ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 3ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 4ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 5ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 6ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 7ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 8
... , JOHANNESBURG, South Africa, Nov. 26 ... the Year Award in the Generic Pharmaceutical Market is ... http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) , For the Company of the ... Cipla Medpro,s performance against key competitors: growth strategy and ...
... , BEDFORD, Mass., Nov. 25 Hologic, Inc. ... developer, manufacturer and supplier of premium diagnostics, medical imaging systems ... women, is using the annual meeting of the Radiological Society ... 29 through December 3, 2009 to highlight our new SecurView(®) ...
Cached Medicine Technology:Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 2Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 3Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 4New Hologic SecurView(R) DX Diagnostic Workstation Software Streamlines Workflow, Improves Radiologist Productivity 2New Hologic SecurView(R) DX Diagnostic Workstation Software Streamlines Workflow, Improves Radiologist Productivity 3New Hologic SecurView(R) DX Diagnostic Workstation Software Streamlines Workflow, Improves Radiologist Productivity 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: