Navigation Links
Acid reflux surgery could help prevent rejection in lung transplant patients
Date:6/28/2013

MAYWOOD, Il. - A Loyola University Medical Center study suggests that a procedure to treat acid reflux could help prevent chronic rejection in lung transplant patients.

The study also found that certain proteins found in lung fluid can help predict whether a patient's transplanted lung is more likely to fail.

Results are published in the July, 2013 issue of the Journal of the American College of Surgeons. Authors are P. Marco Fisichella, MD, FACS (first author), Christopher S. Davis, MD, MPH; Erin Lowery, MD, MS; Luis Ramirez, BS; Richard L. Gamelli, MD, FACS and Elizabeth J. Kovacs, PhD.

Lung transplant patients have the worst survivals of all solid organ transplant recipients. A major reason is bronchiolitis obliterans syndrome (BOS), a condition in which scar tissue forms around small airways in the lungs. BOS results from chronic rejection of the transplanted lung, and affects about half of lung transplant patients within five years.

Following lung transplantation, patients undergo a procedure every few months to inspect the airways. The procedure, called a bronchoscopy, removes fluid from the lung.

Loyola researchers analysed various biomarkers taken from lung fluid during bronchoscopies. Researchers found that, in patients examined 6 to 12 months after transplant, concentrations of certain biomarkers could predict the likelihood of BOS 30 months after transplant. For example, patients with high concentrations of the biomarker myeloperoxidase and low concentrations of the biomarker α-1 antitrypsin were more likely to develop BOS.

The study also found that patients who aspirate (inhale fluid into the lungs) show evidence of a more active immune system. In a condition called acid reflux, gastric contents back up from the stomach into the esophagus and can be inhaled into the lungs. The gastric contents irritate the lungs, triggering the immune system to ramp up and begin rejecting the transplanted lung. As evidence of this, patients who aspirate showed higher levels of neutrophils (a type of immune system white blood cell) and the immune system biomarker interleukin-8 (IL-8).

A minimally invasive procedure called laparoscopic anti-reflux surgery can treat acid reflux. The surgeon reinforces the valve between the esophagus and stomach by wrapping the upper portion of the stomach around the lowest portion of the esophagus. The 90-minute procedure requires five small incisions. Patients typically go home the next day, and take about one week to recover, Fisichella said.

Researchers wrote that their findings "justify the surgical prevention of aspiration and argue for the refinement of antirejection regimens."


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. West Penn Allegheny Health System Physicians Pinpoint Gastroesophageal Reflux Disease (GERD) as a Factor That May Cause Chronic Cough
2. Acid Reflux Treatment
3. How “Heartburn No More” Helps People Treat Acid Reflux – V-kool
4. Gastro Reflux Relief Just Got a Little Cheaper
5. Magnetic Implant May Ease Chronic Acid Reflux
6. Prescription problems for vets on reflux drug
7. Remedies For Heartburn
8. How Heartburn No More Can Help People Treat Acid Reflux Permanently - Tony Nguyen
9. Great recession reflux amounts to more hunger among seniors
10. Bile - not acid - is bad guy in triggering precancerous condition associated with reflux disease
11. Mayo Clinic offers newly approved treatment for acid reflux disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... Washington, D.C. (PRWEB) , ... February 08, 2016 ... ... has officially launched its newly redesigned website, federallabs.org . The site houses ... technologies or license available federal technologies through the process called technology transfer (T2). ...
(Date:2/8/2016)... Houma, LA (PRWEB) , ... February 08, 2016 ... ... Louisiana from offices in Houma, LA, celebrates the beginning of a new charity ... raised to assist Court Appointed Special Advocates (CASA). In the belief that children ...
(Date:2/8/2016)... ... February 08, 2016 , ... Brenton Engineering , ... bags, and flow wrapped products at WestPack 2015, February 9-11, in Anaheim, California. ... up to semi-automatic or fully-automatic case packing with a small footprint, rugged, highly ...
(Date:2/8/2016)... ... February 08, 2016 , ... Steve Helwig & Associates Insurance ... new community enrichment program, has teamed up with Citizens Opposed to Domestic Abuse in ... intimate abuse. To support all those victimized by the fear of violence in their ...
(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California and its affiliated ... , Gary D. Radine, who recently retired as president and CEO of Delta Dental ... 2015 CEO of the Year , helped lead the effort to raise funds for ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 2016  HemaFlo Therapeutics, Inc. announced today that the United ... Number 9,119,880 covering the use of NephroFlow to treat acute ... HemaFlo,s founder, said, "We are pleased to secure our rights ... Peterson , PhD, HemaFlo,s founder, said, "We are pleased to ... --> Dale Peterson , PhD, HemaFlo,s founder, said, ...
(Date:2/8/2016)... Feb. 8, 2016 Palatin Technologies, Inc. ... receptor-specific peptide therapeutics for the treatment of diseases ... announced today that the United States Patent and ... Allowance for U.S. Patent Application Serial Number 14/313,258 ... methods of treating female sexual dysfunction using the ...
(Date:2/5/2016)... , Feb. 5, 2016 Amgen (NASDAQ: AMGN ... Annual Global Healthcare Conference at 9:15 a.m. ET on Wednesday, ... . David W. Meline , executive vice president and ... Live audio of the presentation can be accessed from the ... A replay of the webcast will also be available on ...
Breaking Medicine Technology: