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Acid reflux, functional dyspepsia have significant impact on disordered sleep
Date:10/18/2010

"The improved ESS score suggests that reduced sleepiness contributed to improved performance," said Dr. Johnson. "We know that GERD impairs sleep quality and next day function as measured by quality of life and work productivity assessments. Furthermore, sleep dysfunction (such as sleep apnea) has been linked to impaired psychomotor function including worsening driving simulator performance.

Therefore, appropriate treatment for patients with GERD and nocturnal symptoms may have potentially new and life‐saving implications."

Dr. Johnson also noted that further prospective blinded controlled trials are warranted to validate these findings.

Baclofen Decreases Reflux, Improving Sleep Quality for Nighttime Heartburn Sufferers

Nighttime heartburn sufferers also may get relief and better sleep quality, from the muscle‐relaxant and antispastic drug, baclofen, according to results of another new study unveiled today, "Baclofen Decreases Reflux and Improves Sleep Quality in Individuals with Nighttime Heartburn."

While baclofen has been shown to reduce episodes of GERD, this new study found that in addition to reducing the number of reflux events during sleep, baclofen significantly improved several measures of sleep in patients with documented GERD and sleep disturbances.

"About 70 percent of individuals who have GERD also suffer from nighttime heartburn, and 40 percent of those people say they experience disturbed sleep at night," said study co‐author Dr. William Orr, president and CEO of the Lynn Health Science Institute and a clinical professor of medicine at the University of Oklahoma Health Sciences Center. "They don't feel good the next day and they don't perform as well."

Approved by the FDA in 1977, bacolfen is typically used by neurologists to treat uncontrolled movements, such as shakes and tremors. The drug inhibits nerve activity within the part of the brain that controls the contraction and relaxation
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Contact: Jacqueline Gaulin
mediaonly@acg.gi.org
202-255-5541
American College of Gastroenterology
Source:Eurekalert

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