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Acid reflux, functional dyspepsia have significant impact on disordered sleep
Date:10/18/2010

, Ph.D., associate professor of medicine, Dartmouth Medical School who presented the results of the study. "The key finding here is that disordered sleep may affect nerve function in upper GI tract which could lead to worsening dyspepsia, creating a vicious cycle leading to more pain and more insomnia," said Dr. Lacy. He added that, "future clinical trials for functional dyspepsia should include validated measures of sleep, as improvements in functional dyspepsia symptoms may be mirrored by improvements in sleep."

Esomeprazole Reverses Driving Impairment in GERD Induced Sleep Disorders

GERD‐induced sleep dysfunction has a previously unrecognized and significantly adverse affect on simulated driving performance, which improved with esomeprazole, according to the results of another study, "GERD‐Induced Sleep Disorders and a Reversible Driving Impairment with Esomeprazole‐A Prospective Pilot Study."

Dr. David A. Johnson, Chief of Gastroenterology and Professor of Medicine at Eastern Virginia Medical School in Norfolk, Va., presented the findings from this prospective‐pilot study that evaluated 11 healthy patients with well‐established GERD with nocturnal symptoms.

Testing was done in a validated commercial driving simulator that responds to driver inputs (steering, throttle, brake) and generates realistic roadway images. Driving performance (standard deviation of lane variation SDLP) was compared across six consecutive 10‐minute driving periods while subjects were on and off the drug.

According to the study, SDLP increased over time (p=0.0002) and improved with esomeprazole. Patients on esomeprazole had an overall average 62.5 percent decrease in the number of sleep disordered nights vs. a 9.5 percent decrease without the drug. The Epworth Sleepiness Scale, used to determine the level of daytime sleepiness, decreased to 5.9 and 3.5 from 7.9 and 2.5 and GERD symptom score decreased from 2.10 to 0.33.
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Contact: Jacqueline Gaulin
mediaonly@acg.gi.org
202-255-5541
American College of Gastroenterology
Source:Eurekalert

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