Navigation Links
Acid Reducers May Not Help All With Asthma
Date:4/8/2009

Study finds benefit only for those with evident symptoms of heartburn

WEDNESDAY, April 8 (HealthDay News) -- Acid-suppressing medications won't ease asthma symptoms if you don't have heartburn symptoms, too, a new study has found.

Many people with asthma also have gastroesophageal reflux disease, or GERD. But some people have what's known as silent GERD, meaning they have no symptoms.

Doctors have suspected that if people with asthma breathe in during reflux, they might breathe irritating stomach fluids into the lungs. To reduce that possibility, doctors have been prescribing acid-suppressing medications known as proton pump inhibitors (PPI).

But a study in the April 9 issue of the New England Journal of Medicine repots that a PPI probably isn't going to help lessen wheezing in people with silent GERD.

"Patients with asthma that is not adequately controlled with the usual asthma medications, and who have no symptoms of heartburn, but who may or may not have silent GERD, don't seem to have any improvement of asthma when treated with esomeprazole (Nexium)," said one of the study's authors, Dr. Robert Wise, a professor of medicine in the division of pulmonary and critical care medicine at Johns Hopkins University School of Medicine in Baltimore.

Although the two conditions may seem quite different, doctors have long suspected that they're linked, with each disorder possibly triggering the other. Acid reflux might cause asthma symptoms through aspiration of fluid into the airways, or acid might irritate the esophagus and upper airway, according to the study. And asthma might trigger GERD when it causes difficulty breathing. The diaphragm may overinflate, and the extra pressure may cause the esophageal sphincter to herniate, allowing fluids to wash out of the stomach.

Proton pump inhibitors work by suppressing acid production.

The study, which was funded by the American Lung Association and the U.S. National Institutes of Health, included 412 people whose asthma was badly controlled even though they were being treated with inhaled corticosteroids. All had either no symptoms or just minimal symptoms of GERD. They took 40 milligrams of Nexium or a placebo twice a day.

According to Wise, people given the drug took a larger-than-standard dose. In most people, he said, a 40-mg dose would suppress nearly all acid production in the stomach.

There was no statistically significant difference between those who took Nexium and the placebo group with respect to asthma control, lung function, GERD symptoms, night awakenings and quality of life, the study found. The rate of asthma events was 2.3 per person-year for the placebo group and 2.5 events per person-year for the treatment group.

"Our study showed this is not an effective practice," Wise said. "These drugs are effective for treating heartburn, and if you have asthma and heartburn, then these drugs may well be used for those symptoms."

Wise said the researchers were not advocating that anyone stop taking their medications, but that they should talk with their physicians. "People need to follow their doctor's advice and take their asthma medications on a regular basis," he said.

Blair Hains, a spokesman for AstraZeneca, which makes Nexium, said that the drug is not indicated for use in asthma and asymptomatic GERD. "The vast use is around treatment of GERD and heartburn," he said.

"For those who have asthma and have GERD, we want to make sure they continue to take their medications as directed," Hains said. "If you have questions or concerns because you're taking Nexium or another proton pump inhibitor, talk to your doctor."

More information

The U.S. National Heart, Lung, and Blood Institute has more on asthma treatments.



SOURCES: Robert Wise, M.D., professor of medicine, division of pulmonary and critical care medicine, Johns Hopkins University School of Medicine, Baltimore; Blair Hains, spokesman, AstraZeneca; April 9, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Enzyme and vitamin define the yin and yang of asthma
2. Video: New Childrens Storybook Helps Parents Teach Their Children With Asthma About Their Condition
3. Major Asthma Research Discovery Could Lead to New Drugs
4. New Treatments Improve Control for Severe Asthma
5. Using Music and Sports to Improve Kids Asthma
6. UniCare Health Plan of West Virginia Providing Assistance for Asthma Education Training
7. Experimental Drug May Dampen Severe Asthma
8. 9 key messages about asthma in Australia
9. 2 Hours Glued to TV Doubles Kids Asthma Risk
10. Broccoli may help protect against respiratory conditions like asthma
11. American Lung Association of New England Launches Online Asthma Control Test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Acid Reducers May Not Help All With Asthma
(Date:8/22/2017)... ... ... “To Walk Away”: a captivating and romantic sequel to the romantic story ... is the creation of published author, Larry R. Sherman, a retired chemistry professor from ... religion, as well as four novels. , Though the book opens in 1947, ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Without Love’s Beauty ... neglect, and the struggles faced while hoping for a better life. “Without Love’s ... Judy Von Bernewitz, who spent 13 years working with deprived/neglected adolescents and almost ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: is a ... “Glimpses Of Light” is the creation of published author, J.M. Shepherd, a writer, teacher, ... answers to life’s perplexing mysteries. , Shepherd shares, “Love is one of the least ...
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class ... Fatigue . , As the stress of modern life continually makes more demands on ... use of artificial stimulants can trap people in vicious high/low cycles and can also ...
(Date:8/22/2017)... Indiana (PRWEB) , ... August 22, 2017 , ... Although ... Fourth of July, many communities have begun providing weekend displays, and numerous households celebrate ... most humans, they can be downright terrifying for pets. , Kris Zambo, owner ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... and BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital ... environmental services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new ... robot that uses UVC light energy to kill deadly pathogens such as C. diff ... Tru-D SmartUVC ... Tru-D in action in a ...
(Date:7/31/2017)... July 31, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), has ... Michigan by Crain,s Detroit Business . ... public companies by three-year revenue growth. This year,s edition measures ... To view the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... an incredible triumph," said Phil Hagerman , CEO and ...
(Date:7/28/2017)... July 28, 2017 EnvoyHealth, a Diplomat company, has ... program for CleverCap LITE, a technology designed to improve ... deliver innovative health technology solutions and services that help ... CleverCap LITE offers medication monitoring and ... cover: Records date ...
Breaking Medicine Technology: