Navigation Links
Acid Reducers May Not Help All With Asthma
Date:4/8/2009

Study finds benefit only for those with evident symptoms of heartburn

WEDNESDAY, April 8 (HealthDay News) -- Acid-suppressing medications won't ease asthma symptoms if you don't have heartburn symptoms, too, a new study has found.

Many people with asthma also have gastroesophageal reflux disease, or GERD. But some people have what's known as silent GERD, meaning they have no symptoms.

Doctors have suspected that if people with asthma breathe in during reflux, they might breathe irritating stomach fluids into the lungs. To reduce that possibility, doctors have been prescribing acid-suppressing medications known as proton pump inhibitors (PPI).

But a study in the April 9 issue of the New England Journal of Medicine repots that a PPI probably isn't going to help lessen wheezing in people with silent GERD.

"Patients with asthma that is not adequately controlled with the usual asthma medications, and who have no symptoms of heartburn, but who may or may not have silent GERD, don't seem to have any improvement of asthma when treated with esomeprazole (Nexium)," said one of the study's authors, Dr. Robert Wise, a professor of medicine in the division of pulmonary and critical care medicine at Johns Hopkins University School of Medicine in Baltimore.

Although the two conditions may seem quite different, doctors have long suspected that they're linked, with each disorder possibly triggering the other. Acid reflux might cause asthma symptoms through aspiration of fluid into the airways, or acid might irritate the esophagus and upper airway, according to the study. And asthma might trigger GERD when it causes difficulty breathing. The diaphragm may overinflate, and the extra pressure may cause the esophageal sphincter to herniate, allowing fluids to wash out of the stomach.

Proton pump inhibitors work by suppressing acid production.

The study, which was funded by the American Lung Association and the U.S. National Institutes of Health, included 412 people whose asthma was badly controlled even though they were being treated with inhaled corticosteroids. All had either no symptoms or just minimal symptoms of GERD. They took 40 milligrams of Nexium or a placebo twice a day.

According to Wise, people given the drug took a larger-than-standard dose. In most people, he said, a 40-mg dose would suppress nearly all acid production in the stomach.

There was no statistically significant difference between those who took Nexium and the placebo group with respect to asthma control, lung function, GERD symptoms, night awakenings and quality of life, the study found. The rate of asthma events was 2.3 per person-year for the placebo group and 2.5 events per person-year for the treatment group.

"Our study showed this is not an effective practice," Wise said. "These drugs are effective for treating heartburn, and if you have asthma and heartburn, then these drugs may well be used for those symptoms."

Wise said the researchers were not advocating that anyone stop taking their medications, but that they should talk with their physicians. "People need to follow their doctor's advice and take their asthma medications on a regular basis," he said.

Blair Hains, a spokesman for AstraZeneca, which makes Nexium, said that the drug is not indicated for use in asthma and asymptomatic GERD. "The vast use is around treatment of GERD and heartburn," he said.

"For those who have asthma and have GERD, we want to make sure they continue to take their medications as directed," Hains said. "If you have questions or concerns because you're taking Nexium or another proton pump inhibitor, talk to your doctor."

More information

The U.S. National Heart, Lung, and Blood Institute has more on asthma treatments.



SOURCES: Robert Wise, M.D., professor of medicine, division of pulmonary and critical care medicine, Johns Hopkins University School of Medicine, Baltimore; Blair Hains, spokesman, AstraZeneca; April 9, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Enzyme and vitamin define the yin and yang of asthma
2. Video: New Childrens Storybook Helps Parents Teach Their Children With Asthma About Their Condition
3. Major Asthma Research Discovery Could Lead to New Drugs
4. New Treatments Improve Control for Severe Asthma
5. Using Music and Sports to Improve Kids Asthma
6. UniCare Health Plan of West Virginia Providing Assistance for Asthma Education Training
7. Experimental Drug May Dampen Severe Asthma
8. 9 key messages about asthma in Australia
9. 2 Hours Glued to TV Doubles Kids Asthma Risk
10. Broccoli may help protect against respiratory conditions like asthma
11. American Lung Association of New England Launches Online Asthma Control Test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Acid Reducers May Not Help All With Asthma
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Halo Labs announces the European launch of their new ... at MIBio 2017 in Cambridge, U.K on ... in biopharmaceutical samples with unprecedented speed and sensitivity while using far ... Membrane Imaging. ... particle analysis system ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
Breaking Medicine Technology: