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Acetaminophen use in adolescents linked to doubled risk of asthma
Date:8/13/2010

y increasing oxygen stress resulting from the depletion of glutathione-dependent enzymes, which may in turn lead to enhanced TH2 allergic immune responses. Furthermore, acetaminophen may suppress the immune response to, and prolong the symptomatic illness from, rhinovirus infections, which are a common cause of severe asthma exacerbations in childhood.

Given the increased risk associated with acetaminophen usage, Dr. Beasley and colleagues calculated that the population attributable risksthe percentage of cases that might be avoided if the risk factor were to be eliminatedwere indicative of a remarkable impact from acetaminophen usage.

"The overall population attributable risks for current symptoms of severe asthma were around 40 percent, suggesting that if the associations were causal, they would be of major public health significance," said Dr. Beasley. "Randomized controlled trials are now urgently required to investigate this relationship further and to guide the use of antipyretics, not only in children but in pregnancy and adult life."


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Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

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