Navigation Links
Acetaminophen, Cholesterol Drugs May Help Fight Stroke
Date:4/14/2009

Statins could help prevent attack, while painkiller might minimize damage, studies find

TUESDAY, April 14 (HealthDay News) -- Two new studies find that acetaminophen and statins can be of great benefit in either preventing or treating stroke.

In the first study, statin use seemed to be correlated with a lower risk of having a first stroke, according to a group of French researchers.

Meanwhile, another team in the Netherlands found that patients with a body temperature ranging from normal (98.6 F) to 102.2 F who received acetaminophen soon after the onset of a stroke fared better than patients who did not receive the drug.

Both studies are in the May issue of Lancet Neurology.

Prior studies have suggested that the use of cholesterol-lowering statins -- which include the blockbusters Crestor, Lipitor and Zocor -- can cut the risk of stroke for certain patients.

in the new study, French researchers reviewed 24 studies involving more than 165,000 patients. They found that for every 1 millimole per liter decrease in LDL ("bad") cholesterol brought about by using statins, the risk of stroke fell by about 21 percent, compared to people who did not take these drugs.

The data also suggests that statin use slows the formation of blockages in the carotid arteries, which lead from the heart to the brain.

"It crystallizes the fact that there's a direct relationship between lowering LDL and lowering the risk of stroke," said Dr. Jonathan Friedman, an associate professor of surgery and of neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine. "It's not just a matter of putting patients at risk for stroke on a statin and considering that a success, but actually being aggressive about lowering LDL and monitoring and making sure the response is as significant as you can expect. The amount that you lower the LDL actually matters. That wasn't so obvious to a lot of us," he said.

Then, there's the second study, focusing on the pain reliever acetaminophen -- best known in the United States under the brand name Tylenol. According to background information in the study, many patients having a stroke experience fever, and they tend to have poorer recovery.

"The theory is that certain cells in the brain are not getting enough blood flow, and if the temperature of the body is high, then the metabolic rate of the cells is high, and they need more blood and oxygen -- or they will die," Friedman explained. "If the person is cool, then perhaps the metabolism will slow down and [the brain cells] could live longer."

Currently, guidelines recommend using acetaminophen or a related drug in patients whose temperature is above 99.5 degrees F, although, according to the authors, there has been little evidence to show that this actually improves outcomes.

For this study, 1,400 patients were randomly assigned to receive either acetaminophen or a placebo.

The therapy was started within 12 hours of symptoms of an ischemic stroke (the most common kind) or intracerebral hemorrhage.

Although giving acetaminophen did not significantly benefit the bulk of patients, 40 percent of patients with body temperatures ranging from normal to 102.2 F did benefit significantly, versus only 31 percent of those receiving a placebo.

The study authors warned that acetaminophen should not be dispensed to all patients having a stroke. And even the finding that the drug benefits those with a certain body temperature needs to be confirmed, they added.

Friedman agreed, and said that many doctors are already providing fever-relieving medicines to stroke patients who need it.

"I do not believe that most clinicians are using acetaminophen in the short term with all patients who have stroke, [although] most physicians feel that avoiding fever in people with stroke is important, and we would use acetaminophen in those who have a fever greater than 37.5 Celsius [99.5 F]," Friedman said. "But, we lack much data on that issue, and we definitely don't give acetaminophen to every patient with a stroke."

More information

There's more on the various types of stroke at the American Stroke Association.



SOURCES: Jonathan Friedman, M.D., associate professor, surgery, neuroscience and experimental therapeutics, Texas A&M Health Science Center College of Medicine, associate dean, HSC-College of Medicine Bryan, College Station campus, and director, Texas Brain and Spine Institute; May 2009, Lancet Neurology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. CVS Caremark Study Documents Changes in Prescription Drug Use to Treat High Blood Pressure, High Cholesterol and Diabetes in Children and Adolescents
2. Cheerios(R) Angel de mi Corazon Awards $25,000 to Those Who Fight Heart Disease and High Cholesterol in Hispanic Communities Across the U.S.
3. MSU researcher links cholesterol crystals to cardiovascular attacks
4. Lowest Blood Pressure, Cholesterol Levels the Best
5. Cholesterol Drugs Linked to Increased Fatigue
6. Spoonfuls of Strawberries Help the Cholesterol Go Down
7. Diabetes and Elevated Levels of Cholesterol Linked to Faster Cognitive Decline in Alzheimer's Patients
8. Largest Study to Date Compares Cholesterol Treatment in HIV Patients & Patients Without HIV Infection
9. Anti-Cholesterol Drug May Ease Back Pain
10. Metamucil(R), WomenHeart and Desperate Housewives Star Brenda Strong Partner to Encourage 100,000 Women to Lower Their Cholesterol
11. Got High Cholesterol? Statins Are Not the Only Answer, Says Natural Solutions Magazine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Acetaminophen, Cholesterol Drugs May Help Fight Stroke
(Date:12/2/2016)... ... 02, 2016 , ... Two years ago, Arizona State University ... live by 1 million viewers and won numerous honors, including the region’s top ... the Walter Cronkite School of Journalism and Mass Communication are following up their ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... the launch of its 60-day free trial program for all of the company’s ... the offer a truly hassle free experience. , FlexiSpot’s unique desktop risers use ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... of two ostomy patients, standing as living proof that attitude and determination can ... diseases and issues that spike around the holidays. This campaign will offer patients ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd Regional Conference will ... Spa in Honolulu, offering local frontline clinicians the opportunity to extend their certified ... demand for supplemental training related to pain management has surged dramatically in recent ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... "Pro3rd Accents ... FCPX editors to create versatile lower third titles with just a few clicks of ... Accents Volume 2 includes 30 lower third animations. Choose from various styles with accented ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... ALEXANDRIA, Va. , Dec. 2, 2016 /PRNewswire-USNewswire/ ... year by the Academy of Managed Care Pharmacy ... care organizations can better address the opioid addiction ... Medication Assisted Therapies (MAT). ATAG,s newly ... in Improving Access to Naloxone," addresses many issues ...
(Date:12/2/2016)... 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today announced ... ("PSI").  The combination of Texas -based Maxor ... PSI bring together both company,s clinical expertise and high-touch patient ... industry-leading specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... , Dec. 2, 2016 CVS Health Corporation ... Analyst Day in New York City on Thursday, December 15, 2016, beginning ... leadership team will provide an in-depth review of the ... value. The company will also discuss 2017 earnings guidance ... webcast of the event will be broadcast simultaneously on ...
Breaking Medicine Technology: