Navigation Links
Accurate prognosis for epilepsy patients
Date:7/17/2013

Scientists at Bonn University Hospital and at the Max Planck Institute for neurological research in Cologne have developed a method with which the chances of success of a surgical procedure for temporal lobe epilepsy can be accurately predicted. The rate of accurate predictions is more than 90%. The results are now being presented in the scientific journal "NeuroImage:Clinical."

When many nerve cells simultaneously fire in the brain, an epileptic seizure results. The most frequent form is temporal lobe epilepsy. It originates in one of the two temporal lobes which contain, among other things, important structures for coordinating memory. Because many patients do not respond to medication over the long term, the seizure focus in the affected temporal lobe is often removed in a neurosurgical procedure. However, approximately one-third of patients who undergo surgery do not experience any subsequent improvement. "The procedure is associated with risks -- therefore a reliable prognosis regarding the chances of success is very important," says Prof. Dr. Bernd Weber from the Department of Epileptology of Bonn University Hospital.

An Algorithm Assesses Patients' Brain Images

At the Life&Brain Center, the Bonn epilepsy specialists, together with scientists from the Max Planck Institute for Neurological Research in Cologne, have found a way for the chances of success of a temporal lobe procedure in epilepsy patients to be predicted with a striking degree of accuracy. The researchers used images from magnetic resonance imaging from a total of 49 epilepsy patients who had previously undergone surgical removal of the seizure focus in the left temporal lobe. Using a special computer program developed by Lisa Feis from the Max Planck Institute as a part of her dissertation, the scientists looked at the brain images for differences between the patient group whose seizures had improved following surgery and those with unchanged symptoms. "Using brain images, we trained the algorithm to differentiate in the best possible way between seizure-free and non-seizure-free patients," reports Prof. Weber.

Hitting the Mark with Striking Accuracy

Using the algorithm results, the scientists then calculated the chances of success of an intervention and compared them with the actual findings after the surgery. Because the brains of women and men differ, for example in the symmetry of the halves of the brain, the researchers evaluated the data according to gender. The rate of accurate predictions was 96% in the case of female patients and 94% in the case of male patients.

Additional Research Needed

The tests have been performed retrospectively to date: The researchers applied the method retrospectively on patients who have already undergone surgery. As the next step, the scientists want to examine how well the method predicts chances of success in epilepsy patients who still have yet to undergo a procedure on the temporal lobe. Other university medical centers and even more detailed imaging procedures will be included in this. "At present, we are still at a stage that is too early for clinical application; further research is needed," says Prof. Dr. Christian Elger, director of the Bonn Epilepsy Clinic.


'/>"/>

Contact: Dr. Bernd Weber
bernd.weber@ukb.uni-bonn.de
49-228-688-5262
University of Bonn
Source:Eurekalert

Related medicine news :

1. ACS NSQIP® data is more accurate than administrative data for tracking 30-day hospital readmissions
2. Background mortality rates key to accurate reporting of vaccine safety risks
3. Entertainment and Media Launch National Campaign to Encourage Accurate Storytelling on Mental Health
4. Telerehabilitation allows accurate assessment of patients with low back pain
5. CosmosID unveils new tool for faster, specific and accurate testing of probiotics products
6. Health Strategies & Solutions, Inc., Develops Updated Physician Ratios for More Accurate Forecasting of Physician Need
7. More accurate, powerful genetic analysis tool opens new gene-regulation realms
8. Dual energy CT accurately identifies ACL tears in emergency department
9. AIS’s Directory of Health Plans Celebrates 10 Years of Accurate Health Plan Enrollment Data
10. Norah Guide Offers New Amazingly Accurate Transition Period Guide to Luck and Happiness
11. Florida Social Security Disability Attorney Larry Disparti Says Sequester Cuts Make Filing Accurate, Complete Claims Crucial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... 2017 , ... TransPixel Volume 2 is a set of transitions that create ... effect isolates horizontal and vertical lines of pixels and sorts their pixels by darkness, ... animation and can be changed using a drop-down menu. Create amazing and artistic transitions ...
(Date:7/20/2017)... , ... July 20, 2017 , ... ... firm headquartered in Houston, is pleased to announce their expansion to the Midwest ... housing experience, directors Alysse Hollis and Ronald Bell, and of counsels, John Peck ...
(Date:7/20/2017)... ... July 20, 2017 , ... Doctors on Liens, the leading ... Horine Chiropractic , directed by Dr. Russell Horine, DC to their exclusive list ... run with Dr. Russell Horine serving as the clinic director and his son Dr. ...
(Date:7/20/2017)... ... July 20, 2017 , ... The Dermatology Clinic announced today the ... his BS in Biology from LSU, graduating summa cum laude. He attended Emory University ... his residency in St. Louis, Dr. Dunbar moved to New York to complete an ...
(Date:7/20/2017)... ... July 20, 2017 , ... With nearly half of ... insurance solution company VisitorsCoverage Inc. has launched TMQuotes, a new cloud-based solution platform ... products online, under their own brand. The online marketplace bridges the technological gap ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... 2017  Sysmex America, Inc., a leading provider ... as well as middleware information systems technology, today ... quality assurance easier and more risk free than ... for the innovation that it delivers to the ... assurance processes to a new level with automated, ...
(Date:7/11/2017)... JERUSALEM , July 11, 2017 Oramed ... ), a clinical-stage pharmaceutical company focused on the development ... U.S. Food and Drug Administration (FDA) has agreed to ... successfully completed Phase IIb trial of its oral insulin ... The Phase IIb trial met primary and secondary endpoints ...
(Date:7/10/2017)... 2017 The Institute for In Vitro Sciences ... recipient of a VITROCELL® inhalation exposure system thanks to ... The device, which is designed to replace animals in ... cells to airborne test materials in an environment that ... system for testing combustible tobacco products, as well as ...
Breaking Medicine Technology: