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Access to clinical trials drives dramatic increases in survival from childhood cancer
Date:7/17/2012

More children are surviving cancer in Britain than ever before according to new research published in the cancer journal Annals of Oncology [1] today (Wednesday). The improvement in survival has been driven by the increasing numbers taking part in clinical trials since 1977 when the UK Children's Cancer Study Group (UKCCSG) [2] was established.

The UKCCSG's principal aim was to set up a comprehensive portfolio of national and international trials for the majority of children's cancers. As result, between 1978 and 2005 two-thirds of children diagnosed with cancer in Britain had a cancer type for which there was an open national or international clinical trial. During this time, survival for the whole population of affected children increased significantly in all these categories, with the greatest improvements being seen in germ cell tumours (tumours in the testes and ovaries), and hepatoblastoma (a rare liver tumour). Only 28% of children diagnosed with cancer between 1966-1970 survived for five years. By 2005 this had increased dramatically to 79%

Charles Stiller, Registry Director at the Childhood Cancer Research Group, University of Oxford (UK) and first author of the study, said: "The results of our study show that improvements in childhood cancer survival match those reported by the relevant clinical trials that were running between 1978 and 2005. During this time there has been an increasing level of participation in trials, with around 90% of all children with many types of cancer enrolled, and this has been facilitated by the organisation of care into specialist children's cancer units. These developments have underpinned the substantial improvements in survival seen at the population level in other words, among a large, unselected group of all children with cancer in Britain.

"Although trends in childhood cancer survival have been reported in relation to improvements in treatment in the UK and elsewhere, this is the f
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Contact: Emma Mason
wordmason@mac.com
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3 4

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