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Access Pharmaceuticals Closes Acquisition of MacroChem Corp.
Date:2/26/2009

- Acquisition of Four Clinical Stage Product Candidates Adds to Robust Pipeline -

DALLAS, Feb. 26 /PRNewswire-FirstCall/ -- Access Pharmaceuticals, Inc. (OTCBB: ACCP) announced today that it has closed the acquisition of MacroChem Corporation through the issuance of 2.5 million shares of Access Pharmaceuticals' common stock, as previously announced. Access gains the rights to MacroChem's product portfolio which includes two clinical stage oncology products, 4-thio Ara-C (Thiarabine), which is a next generation nucleoside analogue licensed from Southern Research Institute and sodium phenylbutyrate, which is licensed from the NIH. MacroChem's portfolio of late stage clinical drug candidates includes Pexiganan, a novel topical anti-infective for the treatment of diabetic foot infection that has already completed two Phase 3 clinical trials; EcoNail, a novel topical treatment for onychomycosis that completed a Phase 2 clinical trial; and two proprietary dermatology drug platforms, SEPA(R) and MacroDerm.

"The acquisition of MacroChem brings additional late-stage clinical drug candidates into the Access pipeline," stated Jeffrey B. Davis, Access' President and CEO. "We are currently active in partnering and out-licensing discussions, and MacroChem's assets will be added to that partnering effort. The oncology assets are highly synergistic with the oncology development efforts ongoing at Access and we look forward to the opportunity to move them along in the clinic."

About Thiarabine: Thiarabine, or 4-thio Ara-C, is a next generation nucleoside analogue licensed from Southern Research Institute. The compound has been in two Phase 1/2 solid tumor human clinical trials and was shown to have anti-tumor activity. Access is working with leukemia and lymphoma specialists at M.D. Anderson Cancer Center in Houston and intends to initiate additional Phase 2 clinical trials in adult AML, ALL and other indications.


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SOURCE Access Pharmaceuticals, Inc.
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