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Access Pharmaceuticals Announces New Data on Angiolix(R)
Date:4/17/2008

New Preclinical Data Suggests Potent Anti-Tumor Activity

DALLAS, April 17 /PRNewswire-FirstCall/ -- ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP) announced results from preclinical studies ongoing at the prestigious Imperial College London on Angiolix(R), a proprietary humanized monoclonal antibody. The new data, presented by Dr. Mahendra Deonarain and Laura Bonney, Department of Biochemistry, demonstrate that Angiolix has unusually high accumulation in multiple solid tumor types, including breast and ovarian cancer. Angiolix interferes with binding of a proprietary marker known as lactadherin, which is produced by cancer cells and binds to an adhesion molecule specifically expressed on new blood vessels produced by tumors. Lactadherin is not expressed in normal tissues and therefore it is a suitable marker for tumor targeting. Angiolix has previously been shown by the Cancer Institute of Contra Costa in San Francisco to be able to destroy transplanted human breast cancer tumors.

"This new data shows that Angiolix interferes with binding of lactadherin on new blood vessels and many different tumor types including breast, ovary, stomach, as well with surrounding tissues the extra cellular matrix around tumors and new blood vessels formed by tumors. Angiolix has similar effects to Avastin(R) (Genentech). Avastin targets VEGF instead of lactadherin and since Angiolix works on a different pathway to Avastin, it could potentially be synergistic," said Agamemnon Epenetos, Ph.D., Access' Chief Scientific Officer - Europe. "We believe this two-pronged attack could potentially inhibit the process of angiogenesis and also induce apoptosis, promoting cancer cell death. Based on this data, we are commencing additional studies where Angiolix is administered in combination with chemotherapy in multiple tumor types, including breast and ovarian cancers."

"No other product against the unique tumor marker, Lactadherin, for the treatment of
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SOURCE Access Pharmaceuticals, Inc.
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