Navigation Links
Accelerated chemotherapy given before surgery benefits patients with muscle-invasive bladder cancer
Date:5/17/2012

CHICAGO, IL (May 16, 2012)For some patients with muscle-invasive bladder cancer, treatment may begin before they undergo cystectomy, or surgical removal of the bladder. They may be advised by oncologists to receive chemotherapy before surgery. A large randomized clinical trial published in 2003 demonstrated a survival benefit for neoadjuvant, or pre-surgical, MVAC (methotrexate, vinblastine, doxorubicin and cisplatin) using a standard dose and schedule. However, in an effort to improve toxicity, standard MVAC has been essentially abandoned in favor of other regimens. All current standard neoadjuvant regimens require 12 weeks of chemotherapy.

Now, final results from a phase II clinical trial at Fox Chase Cancer Centerto be presented at the 2012 American Society of Clinical Oncology Annual Meeting on Saturday, June 2point to a treatment regimen that delivers benefits comparable to those of standard MVAC but without the same time requirement. Preliminary findings from the trial show that when MVAC is administered on an accelerated schedule (six weeks instead of 12), accelerated MVAC (AMVAC) patients experienced similar response rates and lower toxicity.

"Accelerated MVAC is an excellent option in terms of efficiency, quick time to surgery, tolerability, and complete response rate," says Elizabeth Plimack, M.D., a medical oncologist at Fox Chase. "It means less time off work for the patient, and less time elapses between their diagnosis and surgery. We hope that this regimen, which is well tolerated and can be given efficiently and quickly without sacrificing effectiveness, will help improve acceptance of neoadjuvant chemotherapy in the medical oncology and urology community."

Plimack and her colleagues recruited patients with muscle-invasive bladder cancer from Fox Chase and the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia. Patients underwent AMVAC every two weeks for six weeks and had a radical cystectomy with
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Accelerated infant growth increases risk of future asthma symptoms in children
2. UCI-led study links prenatal exposure to stress with accelerated cell aging
3. Increased metabolic rate may lead to accelerated aging
4. Chronic stress of cancer causes accelerated telomere shortening
5. Experts call for accelerated national sodium reduction initiatives
6. Accelerated radiation therapy reduces toxicity in patients with advanced head and neck cancers
7. PHNS Implements New Accelerated Claims Resolution Services With iSoftStone
8. Chemotherapys effect on overall survival seems to increase based on tumor size
9. Genetic predictor of breast cancer response to chemotherapy
10. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
11. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... May 25, 2013 A disorder of ... of peripheral neuropathy. According to neuropathy expert doctor Helen ... is estimated that the disorder affects almost 50% of ... arising from Diabetes. The high blood sugar levels in ... patients suffering from it usually tend to have abnormally ...
(Date:5/25/2013)... May 25, 2013 Radius Engineering ... shelter company in the US and has been ... for over 35 years. M.E. and President, Walton ... of NBC Weapon Fundamentals and Shelter Engineering Standards, ... bible on shelter engineering. McCarthy is considered the ...
(Date:5/25/2013)... May 25, 2013 Pradaxa lawsuits ... life-threatening episodes of internal bleeding while using the blood thinner ... District Court, Southern District of Illinois, Bernstein Liebhard LLP reports. ... Pradaxa side effect claims had been filed in ... from 705 claims reported by the Court on May 15th. ...
(Date:5/25/2013)... Many orthodontists have thought about moving ... that cloud is. Most people would naturally assume ... provide their cloud service and support would own and ... they're selling, they'd be wrong. Cloud providers lease ... redundant facility that houses servers and related equipment to ...
(Date:5/25/2013)... CA (PRWEB) May 25, 2013 IBISWorld estimates ... grow at an average annual rate of 28.7% to $1.0 ... 17.9% in 2013. From 2002 and 2008, no new cell ... Culbert, causing relatively modest growth during that period. In the ... approved six new products. This factor contributed to the industry's ...
Breaking Medicine News(10 mins):Health News:Diabetic Neuropathy treatment hits new grounds- Neuracel launches the complete natural treatment 2Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 2Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 3Health News:Pradaxa Lawsuits Mount, as Filings in Federal Pradaxa Side Effect Litigation Exceed 800, Bernstein Liebhard LLP Reports 2Health News:Pradaxa Lawsuits Mount, as Filings in Federal Pradaxa Side Effect Litigation Exceed 800, Bernstein Liebhard LLP Reports 3Health News:Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other 2Health News:Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld 3
... , Cancer Treatment Centers ... from Italy , PHILADELPHIA, Nov. 18 A radiation ... to the current average of six weeks, has arrived at ... CTCA will become the first in the country to offer this ...
... , , NEW YORK, Nov. ... kids, featuring reviews and commentary about products, discoveries on the ... kids behind WAT,s-THE-WORD?! are four young boys who helped their ... Cameron, age 10, recommended to his mom a "cooler" and ...
... , AUSTIN, Texas, Nov. 18 The Advisory Board of ... launch of a new online community for athletes overcoming accident, ... forum where athletes can share stories, set goals and report ... by providing encouragement, advice and mentoring. , IWillAgain.com is inspired ...
... , CALGARY, Nov. 18 /PRNewswire-FirstCall/ - Oncolytics ... announced today that it has entered into an underwriting agreement ... common share and 0.4 of a common share purchase warrant, ... proceeds of US$12,750,000. Each whole common share purchase warrant entitles ...
... , , WASHINGTON, Nov. 18 ... a wholly owned subsidiary of ULLICO Inc., a privately ... Prescription Solutions will provide pharmacy benefit management services to ... union trust funds, union employers and their members with ...
... 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in ... diseases. Nearly 30% of the users suffer from gastric ... the stomach, misoprostol, a non-selective prostaglandin E1 (PGE1) analogue, ... of NSAID-induced injuries, but often induces severe adverse effects. ...
Cached Medicine News:Health News:Radiation Breakthrough Gives Breast Cancer Patients Hope in Single Dose 2Health News:Radiation Breakthrough Gives Breast Cancer Patients Hope in Single Dose 3Health News:WAT-AAH!, The First Functional Bottled Water For Kids, Announces The Release of WAT's-THE-WORD?! 2Health News:IWillAgain.com Launches Online Community for Athletes Overcoming Accident, Illness or Injury 2Health News:Oncolytics Biotech(R) Inc. Announces Terms of Unit Offering 2Health News:Oncolytics Biotech(R) Inc. Announces Terms of Unit Offering 3Health News:Oncolytics Biotech(R) Inc. Announces Terms of Unit Offering 4Health News:Union Labor Life Selects Prescription Solutions To Provide Pharmacy Benefit Management Services 2Health News:Union Labor Life Selects Prescription Solutions To Provide Pharmacy Benefit Management Services 3
(Date:5/23/2013)... -- Texas, premier physician associations today announced the establishment of ... need to provide demonstrably better and more efficient patient ... "I am confident the Physician Services Organization for ... Stephen L. Brotherton , MD, president of the ... doctors are determined to make health care better and ...
(Date:5/23/2013)... 2013  Ameritox, the nation,s leader in pain ... Inc. to become part of its Urine Drug ... costs and improve the clinical outcomes for injured ... benefit manager in the workers, compensation industry, has ... pain management strategy for several years. By establishing ...
(Date:5/23/2013)... Medical Systems, Inc. (NASDAQ: CASM ) (CASMED), a ... that Thomas M. Patton , President and ... Annual Marcum MicroCap Conference on Thursday, May 30, 2013, at ... . The presentation is scheduled to begin ... will be available via a live webcast at http://wsw.com/webcast/marcum/casm/ ...
Breaking Medicine Technology:TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 2Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 3CASMED to Present at the 2nd Annual Marcum MicroCap Conference 2
... VILLAGE, Calif., Dec. 21 Specialists On Call, ... 10,000th emergency teleneurology consultation since the company,s inception. ... SOC,s leadership position as the largest private emergency teleneurology ... when it recently responded to a neurologic emergency at ...
... , LJUBLJANA, Slovenia, Dec. 21 Slovenian Minister of ... Novalis Tx(TM) radiosurgery platform for modern radiotherapy and radiosurgery ... platform from Varian Medical Systems (NYSE: VAR ... the country,s only radiotherapy department access to advanced radiotherapy ...
Cached Medicine Technology:Specialists On Call Delivers 10,000th Emergency Teleneurology Consultation 2Specialists On Call Delivers 10,000th Emergency Teleneurology Consultation 3Slovenia's Sole Radiotherapy Hospital Unveils Novalis Tx(TM) Platform From Varian and BrainLAB 2Slovenia's Sole Radiotherapy Hospital Unveils Novalis Tx(TM) Platform From Varian and BrainLAB 3Slovenia's Sole Radiotherapy Hospital Unveils Novalis Tx(TM) Platform From Varian and BrainLAB 4
... Leptin is a proteohormone with a molecular weight ... by the ob gene and produced by adipocytes [1,2]. ... in the regulation of body weight [1-3]. In ... in both men and women [4]. A relationship ...
ACTIVATED CLOTTING TIME SYSTEM...
... CT is a completely automated, ... performing clotting assays in random ... method of sample management offers ... of STAT samples without the ...
... ACTH (adrenocorticotropic hormone) is synthesized in the ... and is secreted into the peripheral circulation, ... 20 minutes [1]. ACTH is secreted in ... hypothalamus [1]. The actions of CRF are ...
Medicine Products: