Navigation Links
Absence of CLP protein can be indicative of oral cancer
Date:1/7/2009

Poulsbo, WA January 7, 2009 Human calmodulin-like protein (CLP) is found in many cell types including breast, thyroid, prostate, kidney, and skin. The protein can regulate many cell activities and has a highly specific expression. Gaining an understanding about the expression of CLP in oral epithelial cells and its possible downregulation (or lack of production) in cancer may be a potentially valuable marker in early detection of oral cancer. A new study in the Journal of Prosthodontics found that CLP is expressed in normal human oral muscosal cells and that downregulation of this protein may be an indicator of malignancy or cancer.

Michael D. Brooks, DMD, MS, Richard D. Bennett, PhD, Emanuel E. Strehler, PhD, Thomas J. Sebo, MD, PhD, Stephen E. Eckert, DDS, MS, and Alan B. Carr, DMD, MS used a method of staining oral skin cells to see if they expressed this protein. A breast tissue sample that was known to have this protein was used as a basis for comparison. Normal cells in the mouth also possessed CLP. In malignancy or cancer, the same type of skin cells no longer expressed this protein.

In the areas of cancerous cells, a decrease in CLP occurred. There was a sharp contrast in staining quality and clarity between benign and malignant tissue. In the majority of the cancerous regions, a complete lack of CLP was noted.

This may be significant because calmodulin-like protein could be a marker for normal healthy oral cavity cells and diminished or complete loss of the protein could be an indicator of oral cancer or oral cancer development.

"Perhaps a non-invasive method could be developed to screen for oral cancer," the authors note. "Unlike other screening methods that attempt to mark actual cancer cells, this marker would show in healthy cells and would decrease only in cancer transformation."


'/>"/>

Contact: Amy Molnar
professionalnews@bos.blackwellpublishing.net
201-748-8844
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. Spotting Vitamin-D Deficiency in the Absence of Symptoms: ZRT Laboratorys New, One-of-a-Kind Blood Spot Test Answers the Call for Early Detection of Rapidly Rising D-Deficiencies
2. Integrated Benefits Institute Releases Research on True Cost of Absence for Employers
3. Jackson Lewis to Support Presagias Integrated Absence & Disability Management Solution
4. Proteins essential role in repairing damaged cells revealed
5. Redesigned protein accelerates blood clotting
6. 2 Cardiovascular Proteins Tied to Severity of Alzheimers
7. Two cardiovascular proteins pose a double whammy in Alzheimers
8. Manipulating Key Protein May Prevent Eczema
9. Stopping ovarian cancer by blocking proteins coded by notorious gene
10. Tau protein expression predicts breast cancer survival -- though not as expected
11. Einstein researchers discover protein that contributes to cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... agency serving communities in the greater Dallas, Miami, and Raleigh regions, is organizing ... fighting to overcome a rare and deadly chromosome abnormality. , After struggling since ...
(Date:10/13/2017)... WI (PRWEB) , ... October 13, 2017 , ... As ... in medicine known as “patient engagement.” The patient is doing more than filling out ... partners. , “There is an increasing emphasis in health care and research on ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's (ABFM) ... and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton ... until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role of ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile app ... struggle to reverse the tide of prescription drug addiction. The ... their medicine intake and stepping down their dosage in a ... launch in December 2017; the first 100,000 people to sign ... at http://www.rebound-solution.com/ ...
(Date:9/27/2017)... MIAMI , Sept. 27, 2017  Commended for their ... recent notable awards. Ranked as number one in the South ... ninth time in Inc. 5000 yearly list, the national specialty ... CEO, Armando Bardisa will soon be honored by ... Set to receive his award ...
Breaking Medicine Technology: