Navigation Links
Absence of CLP protein can be indicative of oral cancer
Date:1/7/2009

Poulsbo, WA January 7, 2009 Human calmodulin-like protein (CLP) is found in many cell types including breast, thyroid, prostate, kidney, and skin. The protein can regulate many cell activities and has a highly specific expression. Gaining an understanding about the expression of CLP in oral epithelial cells and its possible downregulation (or lack of production) in cancer may be a potentially valuable marker in early detection of oral cancer. A new study in the Journal of Prosthodontics found that CLP is expressed in normal human oral muscosal cells and that downregulation of this protein may be an indicator of malignancy or cancer.

Michael D. Brooks, DMD, MS, Richard D. Bennett, PhD, Emanuel E. Strehler, PhD, Thomas J. Sebo, MD, PhD, Stephen E. Eckert, DDS, MS, and Alan B. Carr, DMD, MS used a method of staining oral skin cells to see if they expressed this protein. A breast tissue sample that was known to have this protein was used as a basis for comparison. Normal cells in the mouth also possessed CLP. In malignancy or cancer, the same type of skin cells no longer expressed this protein.

In the areas of cancerous cells, a decrease in CLP occurred. There was a sharp contrast in staining quality and clarity between benign and malignant tissue. In the majority of the cancerous regions, a complete lack of CLP was noted.

This may be significant because calmodulin-like protein could be a marker for normal healthy oral cavity cells and diminished or complete loss of the protein could be an indicator of oral cancer or oral cancer development.

"Perhaps a non-invasive method could be developed to screen for oral cancer," the authors note. "Unlike other screening methods that attempt to mark actual cancer cells, this marker would show in healthy cells and would decrease only in cancer transformation."


'/>"/>

Contact: Amy Molnar
professionalnews@bos.blackwellpublishing.net
201-748-8844
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. Spotting Vitamin-D Deficiency in the Absence of Symptoms: ZRT Laboratorys New, One-of-a-Kind Blood Spot Test Answers the Call for Early Detection of Rapidly Rising D-Deficiencies
2. Integrated Benefits Institute Releases Research on True Cost of Absence for Employers
3. Jackson Lewis to Support Presagias Integrated Absence & Disability Management Solution
4. Proteins essential role in repairing damaged cells revealed
5. Redesigned protein accelerates blood clotting
6. 2 Cardiovascular Proteins Tied to Severity of Alzheimers
7. Two cardiovascular proteins pose a double whammy in Alzheimers
8. Manipulating Key Protein May Prevent Eczema
9. Stopping ovarian cancer by blocking proteins coded by notorious gene
10. Tau protein expression predicts breast cancer survival -- though not as expected
11. Einstein researchers discover protein that contributes to cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... Homeowners that are wondering how they can tell ... more. Clean Crawls gives 5 signs of poor ... it comes to insulation in their recently released article. ... Clean Crawls, can cause problems throughout your entire home. ... deteriorated, become damp, or been infested with pests should ...
(Date:10/25/2014)... -- Interrupting blood supply to an arm or a leg ... the surgery, according to a new study. "During ... the heart to be able to operate on it. After ... ability to produce energy because it doesn,t get oxygen. When ... such as an arm or a leg, the body prepares ...
(Date:10/25/2014)... large influx of international aid is needed, and soon, ... of deaths from the widening Ebola crisis, a team ... specially designed mathematical model, the researchers looked at the ... populated county of hard-hit Liberia -- Montserrado County, home ... said that if international aid isn,t delivered to Liberia ...
(Date:10/22/2014)... October 22, 2014 At a time ... among parents and athletes at all levels, the ... change the current discussion where two powerful messages are ... therapies that result in full recoveries every day. , ... based in fact and research, UPMC and the Concussion ...
(Date:10/22/2014)... MI (PRWEB) October 22, 2014 ... Schools of Allied Health Professions (ASAHP) Conference on October ... and CEO will participate in a panel discussion on ... Practice. , Isabel Healthcare provides a diagnostic decision support ... improving the diagnosis skills of students and clinical learners. ...
Breaking Medicine News(10 mins):Health News:5 Signs Indicating That Insulation Needs Replacing as Told By Clean Crawls in Recent Article 2Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Experts Predict 'Catastrophic' Ebola Epidemic in West Africa if Aid Delayed 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 3Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 4Health News:Isabel Healthcare to Participate in The Association of Schools of Allied Health Professions (ASAHP) 2014 Conference 2
... , , THURSDAY, Oct. 25 (HealthDay News) -- What,s good for ... have discovered that an extract of broccoli sprouts protects the ... the same as calling the extract a sunscreen, however. , ... the ultraviolet rays of the sun," explained Dr. Paul Talalay, ...
... on Growth of Services Revenues, Higher Margins for ... for 2007 Net Results, POWAY, Calif., Oct. 25 ... of medical diagnostic imaging systems,and services to physicians, offices, ... third quarter and nine months ended,September 30, 2007, on ...
... Ala. Providing HIV combination antiretroviral drug therapy is key ... disease. , Letting nurses and other trained health care workers ... in short supply, is just as important to saving lives, ... at Birmingham (UAB). , Data for the study was gathered ...
... Use, Offer Free Training on Site, SAN DIEGO, ... equipment manufacturer which develops oxygen systems,known worldwide for their ... its portable Eclipse(R) Oxygen System units for,use by wildfire ... portable oxygen concentrator. The 17-pound unit, on,wheels and about ...
... TOWN, Cayman Islands, Oct. 24 United,America Indemnity, Ltd. ... third,quarter of 2007. The Company also announced that its ... to $50 million in the Company,s common,shares through a ... ), Selected financial data for the third quarter ...
... taking steps to help members get the care they ... AET ) is making it,easier for members impacted ... and access employee assistance and,behavior health programs. In addition, ... to help them access care in San Diego,County, where ...
Cached Medicine News:Health News:Broccoli May Help Fight Skin Cancer 2Health News:Broccoli May Help Fight Skin Cancer 3Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 2Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 3Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 4Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 5Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 6Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 7Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 8Health News:Digirad Reports 2007 Third-Quarter, Nine-Month Financial Results 9Health News:JAMA study shows what works in treating HIV-infected African children 2Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 2Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 3Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 4Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 5Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 6Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 7Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 8Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 9Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 10Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 11Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 12Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 13Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 14Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 15Health News:United America Indemnity, Ltd. Reports Third Quarter 2007 Results and Share Repurchase Program 16Health News:Aetna Reminds Members Affected by California Wildfires Where to Call for Help 2Health News:Aetna Reminds Members Affected by California Wildfires Where to Call for Help 3
(Date:10/25/2014)... 24, 2014  As the building blocks of ... access to diverse skill sets and expertise, knowledge ... business hours for efficiency. However, effectively managing these ... According to recent research, more than 25 ... a project not move forward due to lack ...
(Date:10/22/2014)... October 22, 2014 Investor-Edge has ... (NASDAQ: FOLD ), Progenics Pharmaceuticals Inc. (NASDAQ: ... THLD ), Idera Pharmaceuticals Inc. (NASDAQ: ... research on these five companies can be accessed at: ... 2014, the NASDAQ Composite ended at 4,419.48, up 2.40%, ...
(Date:10/22/2014)... Oct. 22, 2014  Paper Pak Industries, a ... APLS ® Body Guard Bio, a disposable, ... of bacteria and virus while protecting service providers ... Bio features a rugged, external nylon shell, watertight ... a leak-proof inner chamber that contains contaminated and ...
Breaking Medicine Technology:Work Around the Clock: Successfully Building & Managing Global Virtual Teams 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2
... 2011 Omeros Corporation (NASDAQ: OMER ) ... in the Company,s Phase 3 clinical program evaluating OMS302 ... proprietary PharmacoSurgery™ products, is added to standard irrigation solution ... maintain intraoperative mydriasis (pupil dilation) and reduce postoperative pain ...
... YORK, Oct. 11, 2011 Reportlinker.com announces ... available in its catalogue: ... 2016 http://www.reportlinker.com/p0336530/Asia-Pacific-Orthopedic-Devices-Market-Outlook-to-2016.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic ... Outlook to 2016 Summary ...
Cached Medicine Technology:Omeros Announces First Patients Treated in Phase 3 Clinical Program Evaluating OMS302 2Omeros Announces First Patients Treated in Phase 3 Clinical Program Evaluating OMS302 3Asia-Pacific Orthopedic Devices Market Outlook to 2016 2Asia-Pacific Orthopedic Devices Market Outlook to 2016 3Asia-Pacific Orthopedic Devices Market Outlook to 2016 4Asia-Pacific Orthopedic Devices Market Outlook to 2016 5Asia-Pacific Orthopedic Devices Market Outlook to 2016 6Asia-Pacific Orthopedic Devices Market Outlook to 2016 7Asia-Pacific Orthopedic Devices Market Outlook to 2016 8Asia-Pacific Orthopedic Devices Market Outlook to 2016 9Asia-Pacific Orthopedic Devices Market Outlook to 2016 10Asia-Pacific Orthopedic Devices Market Outlook to 2016 11Asia-Pacific Orthopedic Devices Market Outlook to 2016 12Asia-Pacific Orthopedic Devices Market Outlook to 2016 13Asia-Pacific Orthopedic Devices Market Outlook to 2016 14Asia-Pacific Orthopedic Devices Market Outlook to 2016 15Asia-Pacific Orthopedic Devices Market Outlook to 2016 16Asia-Pacific Orthopedic Devices Market Outlook to 2016 17Asia-Pacific Orthopedic Devices Market Outlook to 2016 18Asia-Pacific Orthopedic Devices Market Outlook to 2016 19
... 2 O W/O Adapter., ... humidifier systems feature a dual-purpose reservoir with a ... secure attachment of a humidifier adapter. The oxygen ... reaching oxygen delivery tubing. An audible relief valve ...
... EMPTY W/AIR ENT 35%-100% FIO2, ,Empty ... 35% to 100%. It has ports for ... ,Empty Nebulizers 5007P and 5207 have ... , ,Convenient slip-on heaters are also ...
... , One device provides ... therapy from a single gas source ... decreasing the number of SKUs dedicated ... and inconvenience of double or wye ...
MISTY OX® Hi-Fi Nebulizer...
Medicine Products: