Navigation Links
Absence of CLP protein can be indicative of oral cancer
Date:1/7/2009

Poulsbo, WA January 7, 2009 Human calmodulin-like protein (CLP) is found in many cell types including breast, thyroid, prostate, kidney, and skin. The protein can regulate many cell activities and has a highly specific expression. Gaining an understanding about the expression of CLP in oral epithelial cells and its possible downregulation (or lack of production) in cancer may be a potentially valuable marker in early detection of oral cancer. A new study in the Journal of Prosthodontics found that CLP is expressed in normal human oral muscosal cells and that downregulation of this protein may be an indicator of malignancy or cancer.

Michael D. Brooks, DMD, MS, Richard D. Bennett, PhD, Emanuel E. Strehler, PhD, Thomas J. Sebo, MD, PhD, Stephen E. Eckert, DDS, MS, and Alan B. Carr, DMD, MS used a method of staining oral skin cells to see if they expressed this protein. A breast tissue sample that was known to have this protein was used as a basis for comparison. Normal cells in the mouth also possessed CLP. In malignancy or cancer, the same type of skin cells no longer expressed this protein.

In the areas of cancerous cells, a decrease in CLP occurred. There was a sharp contrast in staining quality and clarity between benign and malignant tissue. In the majority of the cancerous regions, a complete lack of CLP was noted.

This may be significant because calmodulin-like protein could be a marker for normal healthy oral cavity cells and diminished or complete loss of the protein could be an indicator of oral cancer or oral cancer development.

"Perhaps a non-invasive method could be developed to screen for oral cancer," the authors note. "Unlike other screening methods that attempt to mark actual cancer cells, this marker would show in healthy cells and would decrease only in cancer transformation."


'/>"/>

Contact: Amy Molnar
professionalnews@bos.blackwellpublishing.net
201-748-8844
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. Spotting Vitamin-D Deficiency in the Absence of Symptoms: ZRT Laboratorys New, One-of-a-Kind Blood Spot Test Answers the Call for Early Detection of Rapidly Rising D-Deficiencies
2. Integrated Benefits Institute Releases Research on True Cost of Absence for Employers
3. Jackson Lewis to Support Presagias Integrated Absence & Disability Management Solution
4. Proteins essential role in repairing damaged cells revealed
5. Redesigned protein accelerates blood clotting
6. 2 Cardiovascular Proteins Tied to Severity of Alzheimers
7. Two cardiovascular proteins pose a double whammy in Alzheimers
8. Manipulating Key Protein May Prevent Eczema
9. Stopping ovarian cancer by blocking proteins coded by notorious gene
10. Tau protein expression predicts breast cancer survival -- though not as expected
11. Einstein researchers discover protein that contributes to cancer spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... Lynx ... among the top US security companies for consecutive years, today announced the appointment ... a year-long independent board nomination process to a close and positions Lynx for ...
(Date:1/17/2017)... ... January 17, 2017 , ... Twelve ... State University’s Athletic Training Education program forged a relationship built upon the foundation ... Program, which is consists of both student members and certified members of the ...
(Date:1/16/2017)... ... , ... California Southern University has named Dr. Steven Beazley University President. ... as a core faculty member, teaching master’s and doctoral courses in the university’s School ... University, where he earned his Doctor of Psychology degree in 1998. Dr. Beazley also ...
(Date:1/16/2017)... ... January 16, 2017 , ... With the Grand Opening Event planned for ... use by sports teams and the general public. Built in five months by Centerpoint, ... be converted into basketball or pickleball courts. The space is also suitable for indoor ...
(Date:1/16/2017)... New York (PRWEB) , ... January 16, 2017 ... ... SightMD today announced the addition of Victor Giamos, MD to their ... of SightMD and Managing Partner at North Shore Eye Care, a division of ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017   Tocagen Inc ., a clinical-stage, ... Ph.D., executive vice president, research and pharmaceutical development at Tocagen, will ... to be held Jan. 17-20 in Miami . ... ... oxymoron: exciting manufacturing for replicating viruses - what to do when ...
(Date:1/17/2017)... ROCKLAND, Mass. , Jan. 17, 2017  EMD ... Germany , in the U.S. and ... R. Smith has joined the company as Senior ... In this role, Mr. Smith will oversee the Fertility ... Fertility Technologies division, which launched its first product last ...
(Date:1/17/2017)... LONDON , January 17, 2017 ... poised to potentially earn millions in revenue with the ... prevent massive numbers of strokes with a simple test ... Biotech Companies with latest developments in the markets today ... PLC (NYSE: AZN ), Cancer Genetics, Inc. ...
Breaking Medicine Technology: