Navigation Links
Abnormal neural activity recorded from the deep brain of Parkinson's disease and dystonia patients
Date:3/9/2011

Movement disorders such as Parkinson's diseases and dystonia are caused by abnormal neural activity of the basal ganglia located deep in the brain. The basal ganglia are connected to the cerebral cortex in the brain surface through complex neural circuits. Their basic structure and connections, as well as the dysfunctions in movement disorders, have been examined extensively by using experimental animals. On the other hand, little is known about the human brain that is much more complex in either normal or diseased states.

An international joint research team led by Professor Toru Itakura and Assistant Professor Hiroki Nishibayashi from Wakayama Medical University, Japan, Professor Atsushi Nambu from the National Institute for Physiological Sciences, Japan, and Professor Hitoshi Kita from The University of Tennessee Health Science Center, TN, succeeded, for the first time, in recording cortically induced neural activity of the basal ganglia in patients with Parkinson's disease and dystonia during stereotaxic neurosurgery for the deep brain stimulation (DBS). This research has been reported in "Movement Disorders".

With the consent of patients and based on the ethical guidelines of Wakayama Medical University, the team recorded the neural activity of the globus pallidus, one of the nuclei in the basal ganglia, and examined their activity changes in response to the stimulation of the primary motor cortex. Typical triphasic responses were observed in patients with Parkinson's disease, and enhanced inhibitory responses were observed in a dystonia patient. The results confirmed previous data observed in experimental animals. These results suggest: 1) Cortically evoked neural responses in the basal ganglia can be useful for determining the target location of the DBS electrodes, and 2) Enhanced inhibitory neural responses in the globus pallidus may cause abnormal movements observed in dystonia.


'/>"/>

Contact: Atsushi Nambu
nambu@nips.ac.jp
81-564-557-771
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists Link Sets of Genetic Abnormalities to Autism Risk
2. Study finds close linkage between a rare, deadly lung condition and blood cell abnormalities
3. Male cancer survivor offspring slightly higher risk of congenital birth abnormalities
4. Researchers use cell profiling to detect abnormalities -- including cancer
5. Abnormal blood vessel function found in women with broken heart syndrome
6. Statins OK for Patients With Abnormal Liver Function: Study
7. Targeted breast ultrasound plays key role in evaluating breast abnormalities in women younger than 40
8. Could brain abnormalities cause antisocial behavior and drug abuse in boys?
9. Vision Abnormality Seen in Close Relatives of Autism Patients
10. Childhood cancer survivors may have abnormal long-term cardiac function
11. Abnormal brain activity in migraineurs is not restricted to attacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... Donuts Franchising Company LLC, announced the first national #QuackGivesBack campaign which supported ... , “This was our first franchise-wide Quack Gives Back initiative, and ...
(Date:12/8/2016)... ... ... CURE Media Group, the nation’s leading digital and print media enterprise focused ... in efforts to combat lung cancer, announced CURE Media Group President Michael J. Hennessy, ... is honored to team up with Upstage Lung Cancer in order to make major ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView ... customers and employees that are both engaging and easy to use. Coming off ... the software company revealed today its plans to roll out new AI-powered self-service ...
(Date:12/8/2016)... ... , ... STAT courier is pleased to announce that due to customer demand, ... expanding their presence in Dallas. One of the most exciting parts for STAT is ... the Dallas and Forth Worth market. STAT takes pride in treating their employees with ...
(Date:12/8/2016)... ... 08, 2016 , ... Vida Health, the digital health platform that ... Canvas Ventures . Other investors include Nokia Growth Partners (NGP) and returning investor ... more consumers who are managing chronic conditions or simply want to improve ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016  EIP Pharma, LLC ( ... proof-of-mechanism for neflamapimod (previously code named VX-745), with ... clinical trials that demonstrated significant Alzheimer,s disease relevant ... treatment) and Study 303 (6-week treatment) are the ... Alzheimer,s Disease (CTAD) scientific conference in ...
(Date:12/8/2016)... A Small Business Innovative Research (SBIR) grant ... (NIH) to Phoenix -based NeuroEM Therapeutics, ... grant will seek to determine an optimal set of ... waves to treat Alzheimer,s Disease. The grant will also ... treat other neurologic disorders such as Parkinson,s Disease and ...
(Date:12/8/2016)... New York , December 8, 2016 ... global Diabetes Injection Pens Market is expected to ... compared to US$4.9 bn in 2015. Between the forecast years ... rise at a CAGR of 7.9%. The leading players operating ... A/S, Eli Lilly and Company, AstraZaneca plc., Biocon Ltd., and ...
Breaking Medicine Technology: