Navigation Links
Abnormal growth regulation may occur in children with heart defects
Date:2/19/2013

The poor growth seen in children born with complex heart defects may result from factors beyond deficient nutrition. A new study by pediatric researchers suggests that abnormalities in overall growth regulation play a role.

"When compared with their healthy peers, children with congenital heart disease have impaired growth, as measured in weight, length, and head circumference," said senior author Meryl S. Cohen, M.D., a pediatric cardiologist in the Cardiac Center at The Children's Hospital of Philadelphia. "We investigated patterns of poor growth in these children, as a starting point in guiding us toward more effective treatments."

The study appeared as an online article in the January 2013 issue of Pediatrics.

The researchers performed a retrospective analysis of medical records of 856 children with congenital heart disease (CHD), compared to 7,654 matched control subjects. All the children were measured up to age 3, and all were drawn from the healthcare network of The Children's Hospital of Philadelphia.

Within weeks of birth, the children with CHD had significant deficits in weight, length and head circumference, compared to matched controls without CHD. The largest differences in weight occurred at 4 months of age. Among the 856 children with CHD, the 248 who required surgical repair were much more likely to be below the 3rd percentile in weight, length and head circumference during early infancy, and their growth by age 3 did not catch up with that of their healthy peers.

In the 608 children with CHD who did not require surgery, growth differences were not as pronounced, but even their growth patterns lagged behind those of healthy controls.

Researchers already knew that children with CHD have an increased risk for poor growth, but this analysis provides a fuller picture of the problem. Cohen observed that in the general population, when caloric intake is insufficient, an infant's weight is usually affected first, followed by length and head circumference. "The fact that all three parameters changed simultaneously rather than sequentially supports the idea that impaired growth in children with heart disease is affected at least in part by factors unrelated to nutrition."

She added that further studies should investigate the possible roles of growth hormones and other physiologic factors that affect growth regulation in children with CHD.


'/>"/>

Contact: Joey McCool Ryan
McCool@email.chop.edu
267-426-6070
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Veterans with mild traumatic brain injury have brain abnormalities
2. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
3. Abnormal DNA maintenance related to cancer
4. Documenting womens experiences with chromosome abnormalities found in new prenatal test
5. Abnormal carotid arteries found in children with kidney disease
6. Double drug combo could shut down abnormal blood vessel growth that feeds disease
7. Brain Scans of Hoarders Show Unique Abnormalities
8. Gene Mutation Linked to Facial, Skull Abnormalities
9. Myelodysplastic Syndrome Linked to Abnormal Stem Cells
10. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
11. Abnormal gene product associated with prostate cancer generated by unusual mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... NE (PRWEB) , ... June 28, 2017 , ... ... Medical has been recognized for excellence in employee engagement. Omaha-based C&A ... the Achievers 50 Most Engaged Workplaces™ in North America for 2017. ...
(Date:6/28/2017)... ... June 28, 2017 , ... Anyone with a remote control has seen the never-ending ... it, you the flipper will get rich in no time. But what about the ... can get for the buyer of a flipped house. An email recently sent to ...
(Date:6/28/2017)... ... ... Park Systems , a leader in Atomic Force Microscopy (AFM) since ... Park customers on July 11, 2017 from 12-2pm at the Thirsty Bear Brewing Company. ... Park Systems, and Prof. Krishna Saraswat , Rickey/Nielsen Professor in the School of ...
(Date:6/28/2017)... ... June 28, 2017 , ... The ... throughout the greater Cincinnati metropolitan area, is teaming up with the local chapter ... with children receiving treatment in nearby hospitals. , Ronald McDonald House of Greater ...
(Date:6/27/2017)... ... 27, 2017 , ... Salucro, the cloud-based payment platform that ... hospitals and provider groups, has announced that it will now offer Parasail’s payment ... a San Francisco health-finance startup that has launched a series of tech-based products ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... 2017  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, ... Iowa location. The ... features an ISO 7 cleanroom—the standard needed to compound intravenous (IV) ... level of pollutants. "Our new ... better serve our Iowa patients," said ...
(Date:6/3/2017)...  Eli Lilly and Company (NYSE: ... Phase 3 MONARCH 2 study showed that abemaciclib, ... combination with fulvestrant, significantly improved progression-free survival (PFS) ... with hormone-receptor-positive (HR+), human epidermal growth factor receptor ... or progressed after endocrine therapy (median PFS, 16.4 ...
(Date:5/30/2017)... 30, 2017 DarioHealth Corp. (NASDAQ: DRIO), a leading global ... announced that it will be presenting at the 7th annual LD ... Erez Raphael , CEO, of DarioHealth will be giving the ... held on June 6th & 7th, 2017 at the Luxe Sunset ... / micro-cap space. About LD ...
Breaking Medicine Technology: