Navigation Links
Abnormal growth regulation may occur in children with heart defects
Date:2/19/2013

The poor growth seen in children born with complex heart defects may result from factors beyond deficient nutrition. A new study by pediatric researchers suggests that abnormalities in overall growth regulation play a role.

"When compared with their healthy peers, children with congenital heart disease have impaired growth, as measured in weight, length, and head circumference," said senior author Meryl S. Cohen, M.D., a pediatric cardiologist in the Cardiac Center at The Children's Hospital of Philadelphia. "We investigated patterns of poor growth in these children, as a starting point in guiding us toward more effective treatments."

The study appeared as an online article in the January 2013 issue of Pediatrics.

The researchers performed a retrospective analysis of medical records of 856 children with congenital heart disease (CHD), compared to 7,654 matched control subjects. All the children were measured up to age 3, and all were drawn from the healthcare network of The Children's Hospital of Philadelphia.

Within weeks of birth, the children with CHD had significant deficits in weight, length and head circumference, compared to matched controls without CHD. The largest differences in weight occurred at 4 months of age. Among the 856 children with CHD, the 248 who required surgical repair were much more likely to be below the 3rd percentile in weight, length and head circumference during early infancy, and their growth by age 3 did not catch up with that of their healthy peers.

In the 608 children with CHD who did not require surgery, growth differences were not as pronounced, but even their growth patterns lagged behind those of healthy controls.

Researchers already knew that children with CHD have an increased risk for poor growth, but this analysis provides a fuller picture of the problem. Cohen observed that in the general population, when caloric intake is insufficient, an infant's weight is usually affected first, followed by length and head circumference. "The fact that all three parameters changed simultaneously rather than sequentially supports the idea that impaired growth in children with heart disease is affected at least in part by factors unrelated to nutrition."

She added that further studies should investigate the possible roles of growth hormones and other physiologic factors that affect growth regulation in children with CHD.


'/>"/>

Contact: Joey McCool Ryan
McCool@email.chop.edu
267-426-6070
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Veterans with mild traumatic brain injury have brain abnormalities
2. Epigenomic abnormalities predict patient survival in non-Hodgkins lymphoma
3. Abnormal DNA maintenance related to cancer
4. Documenting womens experiences with chromosome abnormalities found in new prenatal test
5. Abnormal carotid arteries found in children with kidney disease
6. Double drug combo could shut down abnormal blood vessel growth that feeds disease
7. Brain Scans of Hoarders Show Unique Abnormalities
8. Gene Mutation Linked to Facial, Skull Abnormalities
9. Myelodysplastic Syndrome Linked to Abnormal Stem Cells
10. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
11. Abnormal gene product associated with prostate cancer generated by unusual mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited to ... Recovery® program to drive cancer patients to and from their cancer treatments. Comfort ... quality of life and ongoing independence. Getting to and from medical treatments is ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... People across ... in Genome magazine’s Code Talker Award, an essay contest in which patients and their ... award to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... 2022" report to their offering. ... with kidney failure, it replaces the function of kidneys by ... and thus the treatment helps to keep the patient body,s ... Increasing number of ESRD patients & substantial healthcare ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: