Navigation Links
Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Date:11/13/2007

Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.

Scientists at Emory University School of Medicine, in research with mice, now have discovered more specific information about how this inherited expansion of a normal repeated DNA sequence alters gene expression. The research is reported online in the journal Nature Neuroscience.

The inherited diseases caused by an abnormal number of glutamine repeats (generally, more than 37) are known as polyglutamine, or PolyQ diseases. The diseases lead to a progressive degeneration of nerve cells usually affecting people later in life. Although these diseases share the same abnormal expansion of the repeated glutamine sequence and some symptoms, the repeats for the different PolyQ diseases occur in genes on different chromosomes.

The scientists found that abnormal glutamine repeats interfere with the function of an essential transcription factor called TBP (TATA-box binding protein). In turn, the expanded polyQ sequence alters the interaction of TBP with other transcription factors, leading to neurodegeneration. Transcription is the process by which the genetic code in the DNA sequence is first transcribed into RNA. The RNA is subsequently translated into a protein.

"Our study has a broad impact for understanding transcriptional regulation of gene expression as well as the pathogenesis of neurodegeneration caused by expanded polyglutamine proteins," says Xiao-Jiang Li, MD, PhD, Distinguished Professor of Human Genetics in Emory University School of Medicine and the paper's senior author.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1

Related medicine news :

1. Clinical depression linked to abnormal emotional brain circuits
2. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
3. Abnormal immune cells may cause unprovoked anaphylaxis
4. UP Repeats NCQA Certification in Utilization Management
5. Cancer Doctors Across America Stunned at Governments Ruling Restricting Anemia Management Protocols for Cancer Patients, Call Ruling Interference in Practice of Medicine
6. Stress and Anxiety Interfere With Sleep
7. The ScottCare Corporation Completes Acquisition of Rozinn Electronics, a Leading Manufacturer of Cardiac Diagnostic Products
8. Omnicom Acquires Leading Healthcare Marketing Communications Firm in China
9. Leading Child Abuse Center Releases Back to School Tips to Protect Children From Internet Predators
10. Leading-edge body sensor could help produce sporting champions
11. Hospital Quality Info on Web Can Be Misleading
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... “Love in Tokyo” an independent romantic comedy ... and Amazon and will be released on DVD early next year, by ... Foreigner,” Itsuka, an actress and singer/songwriter, and Jason London, lead from “Dazed and Confused.” ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... will be participating at the highly anticipated Mississippi Gulf Babypalooza on September 19, ... from all over, from Gulfport, Biloxi, and beyond. We will be discussing setting ...
(Date:9/3/2015)... ... ... At Renew Man™, we have seen an increasing number of our clients ... primary care physician dictates and the patient obeys. Instead, our clients are members of ... and empowered to choose their own treatment options. , Recognizing that many men may ...
(Date:9/3/2015)... ... September 03, 2015 , ... About 220,800 new cases of prostate cancer are reported each year, ... diagnosed with prostate cancer during their lifetime. While only one man in 10,000 will typically ... by age 65, according to the American Cancer Society. , Prostate ...
(Date:9/3/2015)... ... ... James Earl Jones will be hosting an upcoming VOICES IN AMERICA segment that highlights ... segment that discusses why it is important for the workplace to be healthier, the ... working environment. , Employers are out billions of dollars year after year due to ...
Breaking Medicine News(10 mins):Health News:The Romantic Comedy Film "Love in Tokyo" Has Been Released on ITunes, Google Play, and Amazon 2Health News:State Farm Agent EJ Roberts to Help Expecting Mothers at the Mississippi Gulf Babypalooza 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 3Health News:Noted Santa Rosa Urologist Dr. Michael Lazar Provides Insights on Prostate Cancer Treatments in Recognition of Prostate Cancer Awareness Month 2Health News:Noted Santa Rosa Urologist Dr. Michael Lazar Provides Insights on Prostate Cancer Treatments in Recognition of Prostate Cancer Awareness Month 3Health News:James Earl Jones Hosts a New "Voices In America" Piece on Making the Workplace Healthier 2
... Ireland Cancer Center of University Hospitals Case Medical Center, in ... the Cancer Research Network, found that the majority of older ... the standard of treatment five years of daily oral ... the February issue of Journal of Clinical Oncology and released ...
... from fentanyl-laden patches , , , FRIDAY, Dec. 21 (HealthDay ... health officials are warning of reports of deaths and dangerous ... are prescribed to treat chronic pain. , The patches deliver ... primarily used by cancer patients who are tolerant to the ...
... Founder and CEO Dennis Gillings, Bain ... ... Quintiles,Transnational Corp. today announced the formation of a new investor,partnership to ... CEO Dennis Gillings, CBE, and the management team.,Gillings and global private ...
... Highlights include generic drug use, diagnostic imaging, ... to improve the quality and efficiency of care ... support for diagnostic,imaging which HealthPartners introduced in February, ... program provides physicians the latest,guidelines from the American ...
... NEWPORT BEACH, Calif., Dec. 21 When men leave ... of care and,treatment. More often than not, a spouse ... often lacks the information and confidence,necessary to provide all ... being under more stress than the patient., Laurel ...
... from 3 to 4 per day after service was added ... -- Simply adding a salad bar to the school lunch ... vegetables, U.S. researchers say. , The University of California, Los ... at three L.A. area schools. The children were interviewed before ...
Cached Medicine News:Health News:Ireland Cancer Center researcher finds standard treatment for breast cancer not followed 2Health News:FDA Renews Warnings on Pain-Relief Patch 2Health News:FDA Renews Warnings on Pain-Relief Patch 3Health News:FDA Renews Warnings on Pain-Relief Patch 4Health News:Quintiles Transnational Forms New Ownership Team with Current Investors Gillings, TPG and Temasek Joined by Bain Capital and 3i 2Health News:Quintiles Transnational Forms New Ownership Team with Current Investors Gillings, TPG and Temasek Joined by Bain Capital and 3i 3Health News:Quintiles Transnational Forms New Ownership Team with Current Investors Gillings, TPG and Temasek Joined by Bain Capital and 3i 4Health News:HealthPartners Reports 2007 Most Cost Effective Programs Reduce Expenses by $74 Million 2Health News:Helping Couples Fight Prostate Cancer, This Week on Your Cancer Today(TM) 2Health News:School Salad Bar Boosts Kids' Fruit, Veggie Intake 2
(Date:9/2/2015)... , Sept. 2, 2015 Research and ... of the "An Introduction to Medical Device ... 2-3, 2015)" conference to their offering. ... introduction to the regulations and requirements that apply ... highly interactive, using real life examples and state-of- ...
(Date:9/2/2015)... 2, 2015  Research and Markets ( http://www.researchandmarkets.com/research/rf2c5p/an_introduction ... "An Introduction to the Medical Devices Directive (London, ... their offering. This seminar provides ... legislation. It will explain the Directives and which ... how to choose one and outline what a ...
(Date:9/2/2015)... 2, 2015 Research and Markets ( http://www.researchandmarkets.com/research/6x789c/new_eu ... EU Pharmacovigilance Legislation (London, UK - November 16-17, 2015)" ... 15 new EU modules concerning Pharmacovigilance are a major ... in Europe . The intention of ... their requirements, examine how they overlap and fit together ...
Breaking Medicine Technology:An Introduction to Medical Device Software: Regulations and Requirements Course - London, UK - November 2-3, 2015 2
... Reportlinker.com announces that a new market research ... Rheumatoid Arthritis Market Forecast ... novel oral drugs and reformulations of current brands ... major markets, rising from $12bn in 2010 to ...
... 2011 Reportlinker.com announces that a ... in its catalogue: ... - Pipeline Assessment and Market Forecasts ... http://www.reportlinker.com/p0617091/Post-Menopausal-Hormone-Replacement-Therapy-HRT---Pipeline-Assessment-and-Market-Forecasts-to-2018.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Therapy Post-Menopausal ...
Cached Medicine Technology:Rheumatoid Arthritis Market Forecast 2Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 2Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 3Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 4Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 5Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 6Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 7Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 8Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 9
... Welch Allyn Frequency Doubling Technology. It ... field testing by combining early glaucoma ... and basic glaucoma management tools., ,Like ... doubles as an in-office glaucoma screener ...
... The Rapidlab 1200's speed and ... critical decisions in a timely manner ... will value, especially patients. In fact, ... all parameters in just one minute. ...
Erbium Laser with Sapphire Erbium Handpiece for Dermatological and Cosmetic Surgery...
... Utilizing process automation, robust ... and EMR/Practice Management), and rules-based ... issues, improves efficiency, reduces errors, ... of Harvest LIS includes many ...
Medicine Products: