Navigation Links
Abnormal gene product associated with prostate cancer generated by unusual mechanism
Date:6/19/2012

cis-SAGe occurred when an RNA that crossed the boundary between the two genes was formed.

The protein CCCTC-binding factor normally acts to insulate SLC45A3 and ELK4 from each other. Li and his colleagues found that levels of this protein at the gene boundary inversely correlated with the amount of SLC45A3-ELK4 fusion RNA generated, providing molecular insight into how the quantity of this fusion RNA could be regulated.

A functional role for the SLC45A3-ELK4 fusion RNA in prostate cancer was suggested by two observations. First, it promoted the growth of the two prostate cancer cell lines in culture. Second, its levels in human prostate samples correlated with prostate cancer disease progression normal prostate tissue expressed the lowest levels and prostate cancer specimens from men with metastatic disease expressed the highest levels.

"These data are not sufficient to say that the SLC45A3-ELK4 fusion RNA has a causal role in prostate cancer," said Li. "But they are highly suggestive, and I am very excited that this high-risk project, which I would not have been able to pursue without the grant from Stand Up To Cancer, has uncovered what seems to be a new way in which cancer can be driven."


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Epilepsy Leads to More Brain Abnormalities Over Time
2. Study Pinpoints New Abnormality in Athletes Heart
3. Insecticide Linked to Brain Abnormalities in Kids
4. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
5. Treatment of childhood OSA reverses brain abnormalities
6. Researchers find evidence of banned antibiotics in poultry products
7. Pig stomach mucins are effective as anti-viral agents for consumer products
8. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
9. Probiotic Products May Prevent Antibiotic-Linked Diarrhea
10. Email Vacations Boost Job Productivity, Lower Stress: Study
11. Productivity gains from health IT must await bigger health system changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... 17, 2014) Two recent papers by a ... colleagues may help scientists develop treatments or vaccines ... Japanese encephalitis and other disease-causing flaviviruses. , Jeffrey ... molecular genetics at the School of Medicine and ... Medical Institute, and colleagues recently published articles in ...
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
(Date:4/17/2014)... Rochelle, NY, April 17, 2014U.S. military personnel who ... plus impact" concussive traumatic brain injury (TBI) were ... evacuated for other medical reasons. Differences in measures ... depression 6-12 months after injury are reported in ... a peer-reviewed journal from Mary Ann Liebert, Inc., ...
(Date:4/17/2014)... It,s estimated that as many as 10 million older ... of loneliness and isolation. , However, new research ... retired older Americans for six years found that ... of depression by more than 30 percent. , "That,s ... State University professor of telecommunication, information studies and media ...
(Date:4/17/2014)... 17, 2014-- Colic affects about one in five infants ... pediatric visits during the first several months after birth. ... was showing promise; however, the April 1, 2014 issue ... Valerie) reported on a study, "Probiotics and Infant Colic," ... reuteri for infant colic did not reduce ...
Breaking Medicine News(10 mins):Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Internet use can help ward off depression among elderly 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... NEW YORK, May 16, 2012 -- A collaboration to ... children is being launched by Cincinnati Children,s Hospital Medical ... Negev (BGU) in Beer-Sheva, Israel. The goal is to ... that is customized to meet childrens, unique physiological differences ...
... May 16, 2012The inaugural issue of BioResearch ... access journal, was released today by Mary Ann ... rapid-publication forum for a broad range of scientific ... cellular biology, tissue engineering and biomaterials, regenerative medicine, ...
... Breast cancer stem cells wear a cell surface protein ... as potent tumor-generating cells and flagging their vulnerability to a ... Center report online in Journal of Clinical Investigation . ... stem cells and also found that it,s targetable with a ...
... has replaced another minimally invasive operation as the main ... the diseased organ, and with comparable results, according to ... While the study shows that robot-assisted partial nephrectomy ... complications than laparoscopic partial nephrectomy (LPN), the researchers cautioned ...
... undergo radical surgery for prostate cancer may expect better ... hospitals with residency programs, and better still if the ... study by Henry Ford Hospital. The study, which ... throughout the U.S., also found that those with fewer ...
... Black prostate cancer patients may not be getting ... to a first-of-its-kind study by researchers at Henry Ford ... surgery to remove diseased prostates. While it is ... why the results of radical prostatectomy are not as ...
Cached Medicine News:Health News:Ben-Gurion U. and Cincinnati Children's Hospital to develop pediatric-specific medical technologies 2Health News:Premier issue of BioResearch Open Access launched by Mary Ann Liebert Inc. publishers 2Health News:Scientists discover marker to identify, attack breast cancer stem cells 2Health News:Scientists discover marker to identify, attack breast cancer stem cells 3Health News:Scientists discover marker to identify, attack breast cancer stem cells 4Health News:Robot-assisted surgery now favored treatment for kidney cancer 2Health News:Fewer prostate cancer surgery complications found in teaching hospitals with fellowship programs 2Health News:Quality of care, other issues may cause worse results in black prostate cancer surgery patients 2
(Date:1/15/2014)... As health officials across the Midwest warn against the ... Michigan will offer free diagnostic testing ... pharmacists to administer tests and, in some cases, fill the ... in the study. The Grand Rapids, ...
(Date:1/15/2014)... N.J. , Jan. 15, 2014  Celsion Corporation (the "Company") ... has received commitments from institutional investors to purchase an ... stock in an at-the-market registered direct offering, led by ... entered into definitive purchase agreements with these investors pursuant ...
(Date:1/15/2014)... 15, 2014  Humberto C. Antunes,  Galderma  worldwide CEO, will ... Journal of Drugs in Dermatology (JDD) at ... The event is January 17-20, 2014, at the Omni Orlando Resort ... The ODAC is a distinguished event that ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
... BRUNSWICK, N.J., Nov. 28, 2011  Johnson & Johnson (NYSE: ... Annual Health Care Conference on Tuesday, Nov. 29 th at ... Chairman, Ethicon will present in a session scheduled at 8:00 a.m. ... investors and other interested parties by accessing the Johnson & Johnson ...
... 2011 The National Association of Drug Diversion ... cooperation between law enforcement, healthcare professionals, state regulatory ... investigation of drug diversion – today applauded the ... Exchange (NPLEx) demonstrating the real-time, stop-sale system in ...
Cached Medicine Technology:Alabama Stop-Sale System Blocks Illegal Sales & Allows Legal Ones 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: