Navigation Links
Abnormal 'editing' of gene messages may be a cause of lupus
Date:5/19/2008

WINSTON-SALEM, N.C. Researchers at Wake Forest University have uncovered evidence that the abnormal editing of gene messages in a type of white blood cell may be behind the development of lupus. Scientists hope the finding will lead to earlier diagnosis, a way to monitor patients response to therapy and possibly a new way to treat the disease.

The findings, reported online in the journal Immunology, involve an enzyme that edits and modifies the messages of genes before the protein-making process. It is protein molecules that carry out the instructions of our genes and determine how an organism looks, how well its body metabolizes food or fights infection, and even how it behaves.

Dama Laxminarayana, Ph.D., assistant professor of internal medicine and senior author, said that in systemic lupus erythematosus, the normal editing process goes awry, causing a shift in the balance of proteins that results in impaired functions in T cells, a type of white blood cell involved in the regulation of immune functions.

Impaired T cell function is a hallmark of lupus, a complex chronic autoimmune disorder that can range from a benign skin disorder to severe, life-threatening multisystem disease. It primarily affects women in the child-bearing years and is more common in blacks.

The current research, which involved 13 patients with lupus and eight healthy participants, was based on Laxminarayanas earlier findings that 150-kDa ADAR1, one of the three enzymes involved in editing gene messages, is higher in the T cells of lupus patients compared to those without lupus. ADARs are ademosine deaminases that act on RNA.

Laxminarayana made the initial finding about 150-kDa ADAR1 levels in 2002 and has been working to solve the mystery of how it is related to the development of lupus. In the current study, Laxminarayana found that the higher levels of 150-kDa ADAR1 alters the editing induced by two other ADAR enzymes and may cause an imbalance of proteins. Editing by the two other ADAR enzymes is a normal cellular process; it is 150-kDa ADAR1 that causes normal editing to go awry.

The process is complicated and took Laxminarayana years to uncover. The current studies demonstrate that, essentially, too much 150-kDa ADAR1 results in an increase in the gene message of Phosphodiesterase 8A1 (PDE8A1), which is involved in the disruption of normal cell signaling and impairing cell function.

150-kDa ADAR1 is the culprit, Laxminarayana said. We are now working to find a safe way to block it.

In addition to targeting the enzyme as a treatment strategy, Laxminarayana said 150-kDa ADAR1 could also be used as a biomarker to detect the disease earlier, to monitor how patients respond to therapy, and to measure disease intensity.


'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Clinical depression linked to abnormal emotional brain circuits
2. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
3. Abnormal immune cells may cause unprovoked anaphylaxis
4. Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
5. CT colonography detects wide-range of extracolonic abnormalities in elderly patients
6. Scientists identify brain abnormalities underlying key element of borderline personality disorder
7. Body Abnormalities, Childhood Cancer May Share Genes
8. Chromosome Abnormalities Raise Risk for Autism
9. Siblings of schizophrenia patients display subtle shape abnormalities in brain
10. HRT Can Lead to Abnormal Mammograms, Biopsies
11. LA BioMed study finds hormone therapy increases frequency of abnormal mammograms, breast biopsies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the ... located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the ... living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an ...
(Date:3/23/2017)... Braunfels, TX (PRWEB) , ... March 23, 2017 , ... ... new clinic, located at 960 Gruene Road in Building 2. The clinic is the ... Dr. Andrew Bennett, PT, says opening the company’s second New Braunfels location brings things ...
(Date:3/23/2017)... ... 2017 , ... The IoT (Internet of Things) is revolutionizing the way the ... on businesses and individual consumers alike. Laboratories can maximize their profit margin by ... from $4 trillion to $11 trillion dollars by the year 2025. McKinsey expects the ...
(Date:3/23/2017)... NY (PRWEB) , ... March 23, 2017 , ... 82% of adults are unaware of ... kids do not brush their teeth the minimum two times a day that dentists recommend. ... students missing 51 million hours of school and adults missing 164 million hours of work ...
(Date:3/23/2017)... ... March 23, 2017 , ... March is National Kidney Month ... punch when it comes to maintaining good health. Every day, two kidneys filter about ... filter every drop of your blood, eliminating waste, regulating fluid levels and blood pressure, ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... VANCOUVER , March 23, 2017 /PRNewswire/ - INVICTUS ... OTC: IVITF; FRA: 8IS) Invictus MD announces that AB ... crops in its licensed production facility under the Access ... Hamilton, Ontario . ... ACMPR in October 2016, is currently operating at half ...
(Date:3/23/2017)... New York , March 23, 2017 /PRNewswire/ ... market exhibits a consolidated vendor landscape with the top ... overall market in 2015. These companies are Stryker ... Inc., Hygia Health Services, Inc., and VANGUARD AG. ... reprocessed medical devices market is witnessing the prevalence ...
(Date:3/23/2017)... 2017 Piramal Pharma ... gibt die Ernennung von Stuart E. Needleman ... globalen Pharmazeutikkunden eine einmalige integrierte End-to-End-Serviceplattform an ... für das erfolgreiche Wachstum und die Umsetzung ... Herr Needleman dafür verantwortlich sein, alle globalen ...
Breaking Medicine Technology: