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Abnormal chromosome indicator of treatment and outcome in patients with rare brain tumor
Date:1/19/2012

was associated with significantly more adverse side effects. The study authors also reported that study participants in both arms whose tumor lacked chromosomes 1p and 19q had longer median survival times as compared with participants without these deletions (> 7 vs. 2.8 years, respectively). This led the study authors to conclude that "tumors with 1p and 19q co-deletion are less aggressive or more responsive to PCV chemotherapy or both."

A recent analysis undertaken of the RTOG 9402 data (at a median study participant follow-up time of 11 years) is planned for submission to the 2012 American Society of Clinical Oncology Annual Meeting. However, due to the finding's significance for patient care, results are reported here in advance of submission.

The abstract reports that the 126 study participants with 1p and 19q co-deletion, the median survival time (MST) of 59 participants randomized to the PCV chemotherapy and RT arm was much longer than the 67 participants randomized to the RT alone arm (14.7 years vs. 7.3 years). Interestingly, for study participants whose tumors contained only one deletion (either 1p or 19q) or no deletions, no difference was found in MST between the two treatment arms (2.6 years vs. 2.7 years).

"The profound association between improved outcome for patients who lack the 1p and 19q chromosomes and were treated with PCV chemotherapy and radiation therapy has significant implication for patients with anaplastic oligodendrogliomas. We now have unequivocal evidence that the chromosomal structure of 1p and 19q co-deletion can be used as a marker to determine which patients will benefit from combined chemotherapy and radiation therapy" says the principal investigator for the RTOG 9402 trial and the abstract's primary author J. Gregory Cairncross, MD, Professor and Head of the Department of Clinical Neurosciences at the University of Calgary, Alberta, Canada.

The other NCI-supported cooperative groups par
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Contact: Shawn Farley
PR@acr.org
703-648-8936
American College of Radiology
Source:Eurekalert

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