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Abnormal chromosome indicator of treatment and outcome in patients with rare brain tumor
Date:1/19/2012

A recent analysis of clinical trial results performed by the Radiation Therapy Oncology Group (RTOG) demonstrate that a chromosomal abnormalityspecifically, the absence (co-deletion) of chromosomes 1p and 19qhave definitive prognostic and predictive value for managing the treatment of adult patients with pure and mixed anaplastic oligodendrogliomas. The presence of the chromosomal abnormality was associated with a substantially better prognosis and near-doubling of median survival time when treatment with combined chemotherapy and radiation therapy was compared to treatment with radiation therapy alone.

Oligodendrogliomas are uncommon tumors that represent approximately 4.0% of all brain tumors. Mixed oliogdendrogliomas (those also containing astrocytic elements) account for 1.0% of all brain tumors. Pure and mixed oligodendrogliomas that contain anaplastic (malignant) cells typically grow more rapidly than non-anaplastic tumors.

The RTOG 9402 trial A Phase III Intergroup Randomized Comparison of Radiation Alone vs. Pre-Radiation Chemotherapy for Pure and Mixed Anaplastic Oligodendrogliomas was conducted with four other National Cancer Institute (NCI)-supported cooperative groups. Trial participants had a pathologically confirmed pure or mixed anaplastic oligodendroglioma and were randomly assigned into one of two treatment arms. The 148 participants randomized to Arm 1 were treated with PCV (procarbazine, CCNU [lomustine] and vincristine) chemotherapy and radiation therapy (RT), and the 143 participants randomized to Arm 2 were treated with RT alone.

RTOG 9402 study results reported with a minimum follow-up time of 3 years in the Journal of Clinical Oncology (2006 Jun 20; 24(18): 2707-14) showed no survival benefit for patients treated with early PVC chemotherapy plus RT over RT alone. Although a significant impact on median progression-free survival time was realized (2.6 years versus 1.7 years for RT alone), the regimen
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Contact: Shawn Farley
PR@acr.org
703-648-8936
American College of Radiology
Source:Eurekalert

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