Navigation Links
Abnormal chromosome indicator of treatment and outcome in patients with rare brain tumor
Date:1/19/2012

A recent analysis of clinical trial results performed by the Radiation Therapy Oncology Group (RTOG) demonstrate that a chromosomal abnormalityspecifically, the absence (co-deletion) of chromosomes 1p and 19qhave definitive prognostic and predictive value for managing the treatment of adult patients with pure and mixed anaplastic oligodendrogliomas. The presence of the chromosomal abnormality was associated with a substantially better prognosis and near-doubling of median survival time when treatment with combined chemotherapy and radiation therapy was compared to treatment with radiation therapy alone.

Oligodendrogliomas are uncommon tumors that represent approximately 4.0% of all brain tumors. Mixed oliogdendrogliomas (those also containing astrocytic elements) account for 1.0% of all brain tumors. Pure and mixed oligodendrogliomas that contain anaplastic (malignant) cells typically grow more rapidly than non-anaplastic tumors.

The RTOG 9402 trial A Phase III Intergroup Randomized Comparison of Radiation Alone vs. Pre-Radiation Chemotherapy for Pure and Mixed Anaplastic Oligodendrogliomas was conducted with four other National Cancer Institute (NCI)-supported cooperative groups. Trial participants had a pathologically confirmed pure or mixed anaplastic oligodendroglioma and were randomly assigned into one of two treatment arms. The 148 participants randomized to Arm 1 were treated with PCV (procarbazine, CCNU [lomustine] and vincristine) chemotherapy and radiation therapy (RT), and the 143 participants randomized to Arm 2 were treated with RT alone.

RTOG 9402 study results reported with a minimum follow-up time of 3 years in the Journal of Clinical Oncology (2006 Jun 20; 24(18): 2707-14) showed no survival benefit for patients treated with early PVC chemotherapy plus RT over RT alone. Although a significant impact on median progression-free survival time was realized (2.6 years versus 1.7 years for RT alone), the regimen was associated with significantly more adverse side effects. The study authors also reported that study participants in both arms whose tumor lacked chromosomes 1p and 19q had longer median survival times as compared with participants without these deletions (> 7 vs. 2.8 years, respectively). This led the study authors to conclude that "tumors with 1p and 19q co-deletion are less aggressive or more responsive to PCV chemotherapy or both."

A recent analysis undertaken of the RTOG 9402 data (at a median study participant follow-up time of 11 years) is planned for submission to the 2012 American Society of Clinical Oncology Annual Meeting. However, due to the finding's significance for patient care, results are reported here in advance of submission.

The abstract reports that the 126 study participants with 1p and 19q co-deletion, the median survival time (MST) of 59 participants randomized to the PCV chemotherapy and RT arm was much longer than the 67 participants randomized to the RT alone arm (14.7 years vs. 7.3 years). Interestingly, for study participants whose tumors contained only one deletion (either 1p or 19q) or no deletions, no difference was found in MST between the two treatment arms (2.6 years vs. 2.7 years).

"The profound association between improved outcome for patients who lack the 1p and 19q chromosomes and were treated with PCV chemotherapy and radiation therapy has significant implication for patients with anaplastic oligodendrogliomas. We now have unequivocal evidence that the chromosomal structure of 1p and 19q co-deletion can be used as a marker to determine which patients will benefit from combined chemotherapy and radiation therapy" says the principal investigator for the RTOG 9402 trial and the abstract's primary author J. Gregory Cairncross, MD, Professor and Head of the Department of Clinical Neurosciences at the University of Calgary, Alberta, Canada.

The other NCI-supported cooperative groups participating in the intergroup (INT 0149) trial are the Eastern Oncology Cooperative Group, SWOG, North Central Cancer Treatment Group, and the NCIC Clinical Trials Group.

"These are exciting and practice-changing results," says Walter J. Curran, Jr., MD, RTOG Group Chair and Executive Director of the Winship Cancer Institute of Emory University in Atlanta. "Given the low incidence of this disease, this achievement required the close collaboration of many groups and centers and everyone associated with the trial should be proud of the accomplishment."


'/>"/>
Contact: Shawn Farley
PR@acr.org
703-648-8936
American College of Radiology
Source:Eurekalert

Related medicine news :

1. Statins may increase risk of interstitial lung abnormalities in smokers
2. Depression and anxiety not linked to delayed resolution of abnormal mammograms, Pap tests
3. Antidepressant linked to developmental brain abnormalities in rodents
4. Could Airway Abnormality Point to Autism?
5. Abnormal Protein May Explain Loss of Smell With Alzheimers
6. Scientists identify a key molecule that blocks abnormal blood vessel growth in tumors
7. Brain Blood Flow Abnormalities Persist in Gulf War Vets
8. Mutant gene identified that causes abnormal chromosome count, leading to cancer
9. Abnormal liver tests associated with increased death rates in people over 75
10. Abnormal brain ultrasounds in premature infants indicate future risk of psychiatric disorders
11. Hereditary colon cancer syndrome marked by abnormally dense blood vessel growth in mouth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... A new ... schedule rates and Medicare rates for a variety of medical services in Illinois ... Evaluation of the 2015 Fee Schedule Rates in Illinois, are professional medical ...
(Date:2/9/2016)... ... February 09, 2016 , ... Establishment Labs, a global ... David Hung to the company´s Board of Directors. , “We are honored ... and an exceptional entrepreneur.” said Juan Jose Chacon Quiros, CEO of Establishment Labs. "David’s ...
(Date:2/9/2016)... County, CA (PRWEB) , ... February 09, 2016 , ... ... on home whitening packages. Teeth whitening is among the most popular cosmetic procedures in ... for their whitening needs. This can put them at risk of teeth whitening-related damage. ...
(Date:2/9/2016)... ... February 09, 2016 , ... Two renowned photographers, Robert ... a photographic adventure on the island, June 14-19, 2016, hosted by Four Seasons Resort ... , After a successful debut in 2015, the Maui Photo Expedition workshop ...
(Date:2/9/2016)... ... February 09, 2016 , ... Shark Finds and Kevin Harrington, and the ... with GRIP-DRY. , GRIP-DRY is a newly patented product that has solved some of the ... the wet and early morning dew or right after a rain shower, might understand the ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... or "Company") (NASDAQ: UNIS ; ASX: UNS), a developer ... results for the second quarter of fiscal 2016 (three months ended ... Financial Results for the Second Quarter of Fiscal 2016 ... for the second quarter of fiscal 2016 was $4.5 million, compared ... from customers for the second quarter of fiscal 2016 were $17.8 ...
(Date:2/9/2016)... Bermuda, Feb. 9, 2016  Axovant Sciences Ltd. ... on the treatment of dementia, today announced further ... cognitive, behavioral and functional aspects of Lewy body ... in the U.S. Two out of the three ... expected to start later this quarter. In addition, ...
(Date:2/9/2016)... Feb. 9, 2016 Hearing protection devices refer ... energy transmitted to the inner ear. Hearing protection devices ... These devices are recommended for users exposed to noise ... refer to HPD that are inserted in the ear ... designed to provide more natural sound perception with the ...
Breaking Medicine Technology: