Navigation Links
Abnormal carotid arteries found in children with kidney disease

A federally funded study led by researchers at Johns Hopkins Children's Center has found that children with mild to moderate kidney disease have abnormally thick neck arteries, a condition known as carotid atherosclerosis, usually seen in older adults with a long history of elevated cholesterol and untreated hypertension.

The findings published online ahead of print on Sept. 13 in the Clinical Journal of the American Society of Nephrology are particularly striking, the researchers say, because they point to serious blood vessel damage much earlier in the disease process than previously thought. As a result, they add, even children with early-stage kidney disease should be monitored aggressively and treated promptly for both hypertension and high cholesterol to reduce the risk for serious complications down the road.

The researchers caution they are not sure whether the same fatty deposits that clog adult arteries are the reason behind the abnormally thick carotid arteries they observed in the study. But because most of the children involved in the research already had high cholesterol and hypertension the leading causes of adult atherosclerosis the investigators believe they are dealing with a disturbingly early onset of this condition in an already vulnerable population.

"Untreated hypertension and high cholesterol increase the risk for long-term vascular damage in any child, but in a child with kidney disease they can wreak much more serious havoc," says study lead investigator Tammy Brady, M.D., M.H.S., a pediatric nephrologist at Hopkins Children's.

Chronic kidney disease by itself increases cardiovascular risk because of chronic inflammation and altered metabolism, the investigators say. But the presence of any additional risk factors such as obesity, high cholesterol and hypertension can further fuel that risk and put children with kidney disease on a path to early heart attack and stroke if left untreated, they add.

In the current multi-center study, which compared 101 children with kidney disease to 97 healthy children, the majority of patients with kidney disease had high blood pressure (87 percent) and elevated cholesterol (55 percent). One-quarter of them were overweight or obese.

Elevated cholesterol and chronically high blood pressure can cause fatty build-up inside the arteries and make them harder and stiffer. A narrowed carotid artery the neck vessel that carries blood from the heart to the brain not only restricts blood flow to the brain but is vulnerable to dangerous fatty plaque ruptures that can lead to heart attacks or strokes.

In their study, researchers performed neck ultrasounds to measure the internal thickness of the carotid artery. On average, children with kidney disease had carotid arteries about 0.02 millimeters thicker than those of children without kidney disease, but some children had arteries up to 0.06 millimeters thicker than their healthy counterparts. High blood pressure and elevated cholesterol increased the difference. Children with hypertension had arteries 0.04 millimeters thicker on average, and children with elevated triglyceride levels had arteries that were 0.05 millimeters thicker.

"We cannot emphasize this enough: Pediatricians who take care of children with chronic kidney disease even kids with early-stage kidney disease should screen them early for cardiovascular damage, assess their risk factors and treat hypertension and high cholesterol promptly and aggressively," Brady says.

An estimated 20 million Americans have chronic kidney disease, according to the CDC. Because chronic kidney disease often evolves silently over a period of years, researchers estimate that many adults with late-stage or end-stage kidney disease developed the disease as children.


Contact: Ekaterina Pesheva
Johns Hopkins Medicine

Related medicine news :

1. Double drug combo could shut down abnormal blood vessel growth that feeds disease
2. Brain Scans of Hoarders Show Unique Abnormalities
3. Gene Mutation Linked to Facial, Skull Abnormalities
4. Myelodysplastic Syndrome Linked to Abnormal Stem Cells
5. Genome-wide analysis shows previously undetected abnormalities in parents of affected children
6. Abnormal gene product associated with prostate cancer generated by unusual mechanism
7. Treatment of childhood OSA reverses brain abnormalities
8. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
9. Insecticide Linked to Brain Abnormalities in Kids
10. Study Pinpoints New Abnormality in Athletes Heart
11. Epilepsy Leads to More Brain Abnormalities Over Time
Post Your Comments:
(Date:11/28/2015)... Aliso Viejo, CA (PRWEB) , ... November 28, 2015 , ... ... 30 new fully customizable media panels to choose from, the possibilities are endless. Users ... angle, and more. With the ProPanel: Pulse masking effects, users are sure to get ...
(Date:11/27/2015)... CO (PRWEB) , ... November 27, 2015 , ... According ... cities are not changing the way that they are handling security in light of ... police and security presence in an attempt to stop an attack from reaching U.S. ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... were," said an inventor from Hillside, N.J. "Many people catch diseases simply from ... that individuals will always be protected from germs." , He developed the patent-pending ...
(Date:11/27/2015)... ... , ... MPWH, the No.1 Herpes-only dating community in the world, revealed that over 50% of ... than 3.7 billion people under the age of 50 – or 67% of the population ... global estimates of HSV-1 infection . , "The data shocks us highly!" said Michelle ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... Secura Consultants has prided itself for not only fulfilling the needs of advisers ... solutions at an affordable price and providing top-tier customer service. However, there's always ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... addition of the "Radioimmunoassay Market by ... (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic Labs), ... Global Forecast to 2020" report to ... has announced the addition of the ...
(Date:11/25/2015)... 25, 2015  Amgen (NASDAQ: AMGN ) today ... with the United States (U.S.) ... biosimilar candidate to Humira ® (adalimumab). Amgen believes ... to the FDA and represents Amgen,s first BLA submission ... Harper , M.D., executive vice president of Research and ...
(Date:11/25/2015)... On Tuesday, November 24, 2015, the ... Wright Medical Technology, Inc. for product liability and ... implant device, awarded $11 million in favor of ... and three days of deliberations, the jury found ... designed and unreasonably dangerous, and that Wright Medical ...
Breaking Medicine Technology: