Navigation Links
Abnormal Protein May Signal Pancreatic Cancer

'Prion' could become diagnostic tool, researcher says

TUESDAY, Aug. 18 (HealthDay News) -- Prion, an abnormal protein, is a biomarker of early pancreatic cancer, a new study suggests.

Prion accumulation causes mad cow disease, but very little is known about prions outside of the brain. This study identified the mechanism by which prions cause pancreatic tumors to grow more aggressively, said researchers at Case Western Reserve University School of Medicine in Cleveland.

They found that prion is incompletely processed in pancreatic cancer cells and binds to a molecule inside the cells called filamin A, which is a regulator of the cell's skeleton and its signaling machineries. By binding to filamin A, incompletely processed prion disrupts the tumor cells' organization and signaling, causing more aggressive cancer growth.

When the prion level is reduced, the cancer cell loses the ability to grow in tissue culture and in animals.

The researchers also found that patients with incompletely processed prion protein in their pancreatic cancer had significantly shorter survival than patients whose tumors didn't have prion.

"Currently, there is no early diagnostic marker for pancreatic cancer. Detection of the incompletely processed prion may provide such a marker. Preventing the binding of prion to filamin A may open new avenues for therapeutic intervention of this deadly disease," study co-author Man-Sun Sy, professor of pathology, said in a university news release.

The study appears in the September issue of the Journal of Clinical Investigation.

More information

The U.S. National Cancer Institute has more about pancreatic cancer.

-- Robert Preidt

SOURCE: Case Western Reserve University, news release, Aug. 17, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers find alcoholics display abnormal brain activity when processing facial expressions
2. Abnormal Brain Circuits May Prevent Movement Disorder
3. Chromosome Abnormality Tied to Autistic Behavior in Mice
4. Patients Often Not Told About Abnormal Test Results
5. Women with previous abnormal cervical cells at higher risk for recurrence and invasive cancer
6. Injured Marines at Risk for Abnormal Bone Growth
7. Injured Marines at risk for abnormal bone growth
8. Abnormal Heartbeat After Bypass a Bad Sign
9. New MR sequence helps radiologists more accurately evaluate abnormalities of the uterus and ovaries
10. Abnormal EKG can predict death in stroke patients
11. Brain abnormality found in boys with attention deficit hyperactivity disorder
Post Your Comments:
Related Image:
Abnormal Protein May Signal Pancreatic Cancer
(Date:12/1/2015)... ... December 01, 2015 , ... Baptist Medical Center Jacksonville has ... the only hospital in the region providing what is known as the world’s ... patients were revealed recently at a medical conference and published in The New ...
(Date:12/1/2015)... TX (PRWEB) , ... December 01, 2015 , ... Dr. ... of Vitenas Cosmetic Surgery, has been named by MedEsthetics magazine as the Best Single ... of the best among the many elite aesthetic physicians honored by the industry publication. ...
(Date:12/1/2015)... ... December 01, 2015 , ... Growth in medical payments ... to decreases in utilization of hospital and nonhospital care, according to a recent study ... Benchmarks for Louisiana, 16th Edition , found medical payments per claim with more than ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... the 1980s we have seen vast improvements in scientific research and discoveries, leading ... strides, providing increased hope and relief to those affected by HIV/AIDS. Mediaplanet’s cross-platform ...
(Date:12/1/2015)... ... , ... It’s official: Tattoo taboo is a thing of the past. One ... (a whopping one in three aged 18 to 25 is inked). As tattoos transition ... ink. In fact, RealSelf , the world’s largest community for learning and sharing ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , December 1, 2015 ... Contraceptive Injectables, Topical Contraceptives, Male Condoms, Female ... Vaginal Rings, Contraceptive Diaphragms, Contraceptive Sponges, Non-Surgical ... Size, Share, Growth, Trends and Forecast 2014 ... Transparency Market Research (TMR).The report states that ...
(Date:12/1/2015)... 1, 2015  InCarda Therapeutics, Inc. (InCarda), a privately-held ... therapies for cardiovascular conditions via the inhalation route, today ... Australia . InCarda is planning to ... Australia in the first half of 2016. ... centers in Adelaide and Melbourne.  ...
(Date:12/1/2015)... 2015 ) ... Alert Systems/Personal Emergency Response System (PERS) Market by ... Forecas" report to their offering. --> ... the "Medical Alert Systems/Personal Emergency Response System ... Geography - Global Forecas" report to their ...
Breaking Medicine Technology: