Navigation Links
Abnormal Protein May Signal Pancreatic Cancer
Date:8/18/2009

'Prion' could become diagnostic tool, researcher says

TUESDAY, Aug. 18 (HealthDay News) -- Prion, an abnormal protein, is a biomarker of early pancreatic cancer, a new study suggests.

Prion accumulation causes mad cow disease, but very little is known about prions outside of the brain. This study identified the mechanism by which prions cause pancreatic tumors to grow more aggressively, said researchers at Case Western Reserve University School of Medicine in Cleveland.

They found that prion is incompletely processed in pancreatic cancer cells and binds to a molecule inside the cells called filamin A, which is a regulator of the cell's skeleton and its signaling machineries. By binding to filamin A, incompletely processed prion disrupts the tumor cells' organization and signaling, causing more aggressive cancer growth.

When the prion level is reduced, the cancer cell loses the ability to grow in tissue culture and in animals.

The researchers also found that patients with incompletely processed prion protein in their pancreatic cancer had significantly shorter survival than patients whose tumors didn't have prion.

"Currently, there is no early diagnostic marker for pancreatic cancer. Detection of the incompletely processed prion may provide such a marker. Preventing the binding of prion to filamin A may open new avenues for therapeutic intervention of this deadly disease," study co-author Man-Sun Sy, professor of pathology, said in a university news release.

The study appears in the September issue of the Journal of Clinical Investigation.

More information

The U.S. National Cancer Institute has more about pancreatic cancer.



-- Robert Preidt



SOURCE: Case Western Reserve University, news release, Aug. 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers find alcoholics display abnormal brain activity when processing facial expressions
2. Abnormal Brain Circuits May Prevent Movement Disorder
3. Chromosome Abnormality Tied to Autistic Behavior in Mice
4. Patients Often Not Told About Abnormal Test Results
5. Women with previous abnormal cervical cells at higher risk for recurrence and invasive cancer
6. Injured Marines at Risk for Abnormal Bone Growth
7. Injured Marines at risk for abnormal bone growth
8. Abnormal Heartbeat After Bypass a Bad Sign
9. New MR sequence helps radiologists more accurately evaluate abnormalities of the uterus and ovaries
10. Abnormal EKG can predict death in stroke patients
11. Brain abnormality found in boys with attention deficit hyperactivity disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Abnormal Protein May Signal Pancreatic Cancer
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... On Dec. ... the Hard Rock Hotel San Diego honoring the 2016 MPN Heroes—eight individuals who have ... (MPNs) by going above and beyond the standard of care, demonstrating leadership within the ...
(Date:12/2/2016)... ... ... Advanced Inc., a leading provider of travel therapy and travel nursing across ... Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason previously served as Vice ... leadership experience to Advanced Inc. He began his career in finance at Ernst & ...
(Date:12/2/2016)... Raleigh, NC (PRWEB) , ... December 02, 2016 , ... ... the Open Enrollment Period (or Annual Election Period), is ending December 7th. Currently-enrolled Medicare ... plan (Part C) or prescription drug plan (Part D) need to make changes during ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... interview of two ostomy patients, standing as living proof that attitude and determination ... digestive diseases and issues that spike around the holidays. This campaign will offer ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Health" in USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized ... fulfilling lives. “We are prolonging life 6 years in the last 3 decades,” ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 According to a ... by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical ... Nephrology, Infectious Diseases) - Forecast to 2021" published ... USD 60.22 Billion in 2016. This market is ... during the forecast period (2016-2021) to reach USD ...
(Date:12/2/2016)...  The Addiction Treatment Advisory Group (ATAG), created ... Pharmacy (AMCP), has released detailed findings on how ... addiction crisis, including through improved access to naloxone ... newly released paper, "The Role of Managed Care ... issues around gaps and barriers to addiction treatment ...
(Date:12/2/2016)... -- Boston Scientific Corporation (NYSE: BSX ) ... assets and capabilities of the Neovasc, Inc., (NASDAQ: ... as well as a 15% equity stake in Neovasc, ... Neovasc advanced biological tissue business makes elements used in ... System. * Upon completion of the transaction, the ...
Breaking Medicine Technology: