Navigation Links
Abnormal Protein May Signal Pancreatic Cancer
Date:8/18/2009

'Prion' could become diagnostic tool, researcher says

TUESDAY, Aug. 18 (HealthDay News) -- Prion, an abnormal protein, is a biomarker of early pancreatic cancer, a new study suggests.

Prion accumulation causes mad cow disease, but very little is known about prions outside of the brain. This study identified the mechanism by which prions cause pancreatic tumors to grow more aggressively, said researchers at Case Western Reserve University School of Medicine in Cleveland.

They found that prion is incompletely processed in pancreatic cancer cells and binds to a molecule inside the cells called filamin A, which is a regulator of the cell's skeleton and its signaling machineries. By binding to filamin A, incompletely processed prion disrupts the tumor cells' organization and signaling, causing more aggressive cancer growth.

When the prion level is reduced, the cancer cell loses the ability to grow in tissue culture and in animals.

The researchers also found that patients with incompletely processed prion protein in their pancreatic cancer had significantly shorter survival than patients whose tumors didn't have prion.

"Currently, there is no early diagnostic marker for pancreatic cancer. Detection of the incompletely processed prion may provide such a marker. Preventing the binding of prion to filamin A may open new avenues for therapeutic intervention of this deadly disease," study co-author Man-Sun Sy, professor of pathology, said in a university news release.

The study appears in the September issue of the Journal of Clinical Investigation.

More information

The U.S. National Cancer Institute has more about pancreatic cancer.



-- Robert Preidt



SOURCE: Case Western Reserve University, news release, Aug. 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers find alcoholics display abnormal brain activity when processing facial expressions
2. Abnormal Brain Circuits May Prevent Movement Disorder
3. Chromosome Abnormality Tied to Autistic Behavior in Mice
4. Patients Often Not Told About Abnormal Test Results
5. Women with previous abnormal cervical cells at higher risk for recurrence and invasive cancer
6. Injured Marines at Risk for Abnormal Bone Growth
7. Injured Marines at risk for abnormal bone growth
8. Abnormal Heartbeat After Bypass a Bad Sign
9. New MR sequence helps radiologists more accurately evaluate abnormalities of the uterus and ovaries
10. Abnormal EKG can predict death in stroke patients
11. Brain abnormality found in boys with attention deficit hyperactivity disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Abnormal Protein May Signal Pancreatic Cancer
(Date:3/24/2017)... ... 24, 2017 , ... As the standards bearer of advanced ... that positions them as the go-to thought leader in all matters concerning oncology ... an always-on, always-fresh news, views and advocacy engine, called ONS Voice. , The ...
(Date:3/24/2017)... ... ... Viewers who like to educate themselves on current issues and who enjoy ... societal issues tend to appreciate and love the "Informed" series, hosted by Rob Lowe. ... for causes around the world. , Running for charity has become a ...
(Date:3/24/2017)... ... , ... “Finding Christ Through Social Media: Year One #A365DayJourney ... writer’s path toward true communion with God. “Finding Christ Through Social Media: Year ... of published author Lea Michelle Johnson, a follower of Christ, wife and mother ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Adventures of Joey, The Dog ... dog who lives his life to the fullest, as God intended. “The Adventures of ... Holmgren, a mother and grandmother pursuing her passion for writing, especially about truth and ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... their communities, 16 more public health departments have been awarded national accreditation through ... 4.5 million people into the expanding network of communities across the nation whose ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 ... to develop sutezolid as effective response to infectious disease ... Alliance and the Medicines Patent Pool (MPP) announced a ... antibiotic drug candidate which demonstrated encouraging results in early ... in combination with other TB drugs and follows the ...
(Date:3/23/2017)... , March 23, 2017 The ... ageing population, increasing diabetic population, accelerating economic growth and increasing ... this industry are higher life expectancy of ESRD patients, rising ... emerging markets. However, the expansion of the market is hindered ... ...
(Date:3/23/2017)... INDIANAPOLIS , March 23, 2017 /PRNewswire/ ... and the William Sansum Diabetes Center have established a ... affected by diabetes through enhanced research, education and care. ... cardiovascular disease bears a disproportionate weight on Latino families ... David Kerr , M.D., FRCPE, director of Innovation ...
Breaking Medicine Technology: