Navigation Links
Abnormal Protein May Signal Pancreatic Cancer
Date:8/18/2009

'Prion' could become diagnostic tool, researcher says

TUESDAY, Aug. 18 (HealthDay News) -- Prion, an abnormal protein, is a biomarker of early pancreatic cancer, a new study suggests.

Prion accumulation causes mad cow disease, but very little is known about prions outside of the brain. This study identified the mechanism by which prions cause pancreatic tumors to grow more aggressively, said researchers at Case Western Reserve University School of Medicine in Cleveland.

They found that prion is incompletely processed in pancreatic cancer cells and binds to a molecule inside the cells called filamin A, which is a regulator of the cell's skeleton and its signaling machineries. By binding to filamin A, incompletely processed prion disrupts the tumor cells' organization and signaling, causing more aggressive cancer growth.

When the prion level is reduced, the cancer cell loses the ability to grow in tissue culture and in animals.

The researchers also found that patients with incompletely processed prion protein in their pancreatic cancer had significantly shorter survival than patients whose tumors didn't have prion.

"Currently, there is no early diagnostic marker for pancreatic cancer. Detection of the incompletely processed prion may provide such a marker. Preventing the binding of prion to filamin A may open new avenues for therapeutic intervention of this deadly disease," study co-author Man-Sun Sy, professor of pathology, said in a university news release.

The study appears in the September issue of the Journal of Clinical Investigation.

More information

The U.S. National Cancer Institute has more about pancreatic cancer.



-- Robert Preidt



SOURCE: Case Western Reserve University, news release, Aug. 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers find alcoholics display abnormal brain activity when processing facial expressions
2. Abnormal Brain Circuits May Prevent Movement Disorder
3. Chromosome Abnormality Tied to Autistic Behavior in Mice
4. Patients Often Not Told About Abnormal Test Results
5. Women with previous abnormal cervical cells at higher risk for recurrence and invasive cancer
6. Injured Marines at Risk for Abnormal Bone Growth
7. Injured Marines at risk for abnormal bone growth
8. Abnormal Heartbeat After Bypass a Bad Sign
9. New MR sequence helps radiologists more accurately evaluate abnormalities of the uterus and ovaries
10. Abnormal EKG can predict death in stroke patients
11. Brain abnormality found in boys with attention deficit hyperactivity disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Abnormal Protein May Signal Pancreatic Cancer
(Date:2/12/2016)... ... ... The law firm of Morrow, Morrow, Ryan & Bassett is offering scholarships to ... to encourage applicants to pursue a degree in their field of study and upon ... “We have available jobs in St. Landry and Evangeline Parishes that can be filled ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, ... ... in Store?, Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, ... burner issue in the life cycle of pharmaceutical products, garnering increased attention from ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a ... closed for the ISE Southeast Awards 2016. Finalists and winners of the ISE® ... Southeast Executive Forum and Awards Gala on March 15, 2016 at the Westin ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Fisher House Foundation ... Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns ... the VA Southern Nevada Healthcare System. This will be the first Fisher House ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Erlanger Agency ... the greater Columbus, OH area. The latest campaign focuses on the fight against breast ... Donations are now being accepted here . , Carmen is a loving single ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)...  Memorial Hermann Health System has teamed up with ... bring a one-of-a-kind experience to pediatric patients at ... as 360-degree video and Google Cardboard, Howard was able ... giving the patients and their families an unexpected, and ... on video . Memorial Hermann IRONMAN ...
(Date:2/12/2016)... Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... the Company will ring the Nasdaq Closing Bell at ... York at 4:00 p.m. ET on Tuesday, ... Adrian Adams , will perform the ... to 4:00 p.m. ET.  A live webcast will be ...
(Date:2/12/2016)... 2016 --> ... Inflammation Global Clinical Trials Review, H2, 2015 provides ... clinical trials landscape along with top level data ... (G7 & E7), Trial Status, Trial Phase, Sponsor ... companies involved and enlists all trials (Trial title, ...
Breaking Medicine Technology: