Navigation Links
Abnormal Protein May Explain Loss of Smell With Alzheimer's
Date:9/29/2011

THURSDAY, Sept. 29 (HealthDay News) -- A loss of a sense of smell can be one of the earliest signs of Alzheimer's disease.

New research suggests that an abnormal form of a protein -- amyloid precursor protein, or APP -- which has been previously associated with the Alzheimer's disease may be to blame.

A study in mice found that animals genetically engineered to produce high levels of the abnormal protein experienced high levels of death in nerve cells in their nose compared to normal mice.

Researchers say the findings may explain why people suffering from the progressive illness often lose their sense of smell while the disease is still in its initial stages. They added this new insight might help doctors detect the condition early on.

"Deficits in odor detection and discrimination are among the earliest symptoms of Alzheimer's disease, suggesting that the sense of smell can potentially serve as a canary in the coal mine for early diagnosis of the disease," study leader Leonardo Belluscio of the U.S. National Institute of Neurological Disorders and Stroke, said in a news release.

"The changes taking place in the olfactory system as a result of Alzheimer's disease may be similar to those in other regions of the brain but appear more rapidly," he added.

APP has been detected in the nose nerve cells of some people with early onset Alzheimer's, a rare form of the disease that runs in families and strikes before age 65.

The researchers found mice making the mutated form of APP had four times as much olfactory nerve cell death at three weeks of age than normal mice.

When researchers blocked the production of high levels of the mutated protein, more olfactory nerve cells survived.

"Reducing APP production suppressed the widespread loss of nerve cells, suggesting that such disease-related death of nerve cells could potentially be stopped," explained Belluscio.

The study, publ
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New study finds 70 percent of able-bodied hockey players have abnormal hip and pelvis MRIs
2. Autism Consortium study in Pediatrics shows CMA finds more genetic abnormalities than current tests
3. Mount Sinai researchers are the first to identify heart abnormalities in World Trade Center workers
4. Researchers ID brain abnormalities in children exposed to methamphetamine in utero
5. Abnormal Heart Rhythm Linked to Alzheimers
6. High doses of antioxidant supplements induce stem cell genetic abnormalities
7. Visually guided laser may be viable treatment for abnormal heartbeat
8. Cold sore virus may contribute to cognitive and brain abnormalities in schizophrenia
9. Harmless Brain Abnormalities in Kids Pose Disclosure Dilemmas
10. Specially trained nurse practitioner detected same breast abnormalities as surgeon
11. Abnormal brain activity in migraineurs is not restricted to attacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... is a popular high school sport in the United ... study by researchers in the Center for Injury Research ... to compare and describe the occurrence and distribution patterns ... high school athletic training setting among adolescents and teens. ... of Athletic Training , examined data relating to adolescents ...
(Date:4/22/2014)... have characterized a set of clock genes that drive ... of species, from flies to humans. Over 15 mammalian ... are more. A team from the Perelman School of ... approaches could find them. , To accelerate clock-gene ... of Pharmacology and first author Ron Anafi, MD, PhD, ...
(Date:4/22/2014)... of all lung cancers are small cell lung ... resistance to chemotherapy. However, researchers at Virginia Commonwealth ... into the mechanisms leading to this resistance that ... work primarily by mediating B-cell lymphoma 2 (Bcl-2) ... death. Depending on their function, this family of ...
(Date:4/22/2014)... The International Communication Association will hold its ... The theme of the 2014 conference will explore ... and digital society. , Featuring over 2,300 academic ... Communication scholars representing over 40 countries, the ICA ... in the world. This year,s conference features sessions ...
(Date:4/22/2014)... is available in German . ... intracellular signaling molecules, but their mode of action is ... cellular function and behavior, while at high concentrations they ... DNA. To analyze how redox signaling unfolds in single ... technique has been developed jointly by the teams of ...
Breaking Medicine News(10 mins):Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 2Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 3Health News:Bioinformatics profiling identifies a new mammalian clock gene 2Health News:Scientists pinpoint protein that could improve small cell lung cancer therapies 2Health News:International Communication Association to hold Annual Conference in Seattle, Washington 2Health News:Neuroimaging: Live from inside the cell 2
... effect on quality of life. New invasive procedures, such ... stimulation, may help patients with chronic refractory headache. This ... and co-authors from the Department of Neurology at the ... Deutsches rzteblatt International (Dtsch Arztebl Int 2011; ...
... Aug. 24 (HealthDay News) -- Exclusive breast-feeding of infants ... against developing the itchy skin disorder known as eczema ... an infant receives only breast milk, with no additional ... Exclusive breast-feeding up to 6 months of age is ...
... in the UK, US and Canada are undermining tobacco prevention ... report by public health researchers says. The paper, published in ... films with tobacco imagery should be ineligible for public funding ... public health goals. Earlier research shows that young people ...
... Reporter , TUESDAY, Aug. 23 (HealthDay News) -- From ... in what,s been dubbed the "mancession" are redefining their ... working partners, a small study suggests. University of ... interviews of 19 recently unemployed men. She and her ...
... HealthDay Reporter , TUESDAY, Aug. 23 (HealthDay News) ... to treat psoriasis -- an autoimmune disorder triggering itchy, ... linked to higher heart risks. But, the study ... makers impeded their ability to assess potential dangers noted ...
... , CHAMPAIGN, Ill. Assembling chemicals can be like ... developed a way of fitting the pieces together to ... and promising antioxidant. Led by chemistry professor Martin ... of the chemistry journal Angewandte Chemie . ...
Cached Medicine News:Health News:Breast-Feeding Won't Prevent Kids' Eczema, Researchers Say 2Health News:Government subsidies to the US film industry promote youth smoking, argue researchers 2Health News:In Tough Times, Jobless Men Embrace Housework 2Health News:In Tough Times, Jobless Men Embrace Housework 3Health News:Injectable Psoriasis Drugs May Not Hike Heart Risks: Study 2Health News:Injectable Psoriasis Drugs May Not Hike Heart Risks: Study 3Health News:A new set of building blocks for simple synthesis of complex molecules 2
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading health care ... new IT value-added reseller (VAR) national contracts that expand ... and services at lower costs. These include manufacturer product ... as initiative assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... 2014 BreedIT Corp (OTC: BRDT), through ... of highly sophisticated agro-breeding solutions for plant breeders and ... Company,s board of directors appointed chemistry and pharmaceutical industry ... member of the board. From 1975 to ...
(Date:1/15/2014)... Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... Symphony® CGM System as a non-invasive, wireless continuous glucose ... , Executive Chairman and Interim CEO of Echo Therapeutics, ... Annual Equity Conference. Mr. Doman will ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
...  The Centers for Disease Control and Prevention (CDC) has ... as many people as car accidents.  Drug diversion is ... as the U.S. House of Representatives Energy and Commerce ... – "Prescription Drug Diversion: Combating the Scourge" ...
... SYDNEY, March 1, 2012  In a single bound, Nepean ... radiation therapy for its prostate cancer cases to a ... Arc Therapy), a technique that is even quicker with ... NCCC physicians treated their first patient with prostate cancer ...
Cached Medicine Technology:Australian Clinic Puts Prostate Cancer Radiation Therapy on Fast Track With Elekta VMAT and Integrity Digital Control System 2Australian Clinic Puts Prostate Cancer Radiation Therapy on Fast Track With Elekta VMAT and Integrity Digital Control System 3
The AcuMatch M-Series modular femoral stem is a unique, innovative three-piece modular stem designed to address even the most complicated of clinical indications....
The link classic plus hip stem for cemented primary hip replacement surgery...
The uncemented hip joint prosthesis system...
The Quatroloc primary hip system offers 35 primary stems to fit almost all femurs for primary hip arthroplasty....
Medicine Products: