Navigation Links
Abnormal Protein May Explain Loss of Smell With Alzheimer's
Date:9/29/2011

THURSDAY, Sept. 29 (HealthDay News) -- A loss of a sense of smell can be one of the earliest signs of Alzheimer's disease.

New research suggests that an abnormal form of a protein -- amyloid precursor protein, or APP -- which has been previously associated with the Alzheimer's disease may be to blame.

A study in mice found that animals genetically engineered to produce high levels of the abnormal protein experienced high levels of death in nerve cells in their nose compared to normal mice.

Researchers say the findings may explain why people suffering from the progressive illness often lose their sense of smell while the disease is still in its initial stages. They added this new insight might help doctors detect the condition early on.

"Deficits in odor detection and discrimination are among the earliest symptoms of Alzheimer's disease, suggesting that the sense of smell can potentially serve as a canary in the coal mine for early diagnosis of the disease," study leader Leonardo Belluscio of the U.S. National Institute of Neurological Disorders and Stroke, said in a news release.

"The changes taking place in the olfactory system as a result of Alzheimer's disease may be similar to those in other regions of the brain but appear more rapidly," he added.

APP has been detected in the nose nerve cells of some people with early onset Alzheimer's, a rare form of the disease that runs in families and strikes before age 65.

The researchers found mice making the mutated form of APP had four times as much olfactory nerve cell death at three weeks of age than normal mice.

When researchers blocked the production of high levels of the mutated protein, more olfactory nerve cells survived.

"Reducing APP production suppressed the widespread loss of nerve cells, suggesting that such disease-related death of nerve cells could potentially be stopped," explained Belluscio.

The study, publ
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. New study finds 70 percent of able-bodied hockey players have abnormal hip and pelvis MRIs
2. Autism Consortium study in Pediatrics shows CMA finds more genetic abnormalities than current tests
3. Mount Sinai researchers are the first to identify heart abnormalities in World Trade Center workers
4. Researchers ID brain abnormalities in children exposed to methamphetamine in utero
5. Abnormal Heart Rhythm Linked to Alzheimers
6. High doses of antioxidant supplements induce stem cell genetic abnormalities
7. Visually guided laser may be viable treatment for abnormal heartbeat
8. Cold sore virus may contribute to cognitive and brain abnormalities in schizophrenia
9. Harmless Brain Abnormalities in Kids Pose Disclosure Dilemmas
10. Specially trained nurse practitioner detected same breast abnormalities as surgeon
11. Abnormal brain activity in migraineurs is not restricted to attacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... According to the Metabolic Enhancement Training program ... bodybuilding program that helps men lose body fat and ... The program also instructs men how to melt fat ... reveals in its review that this program includes a ... get ripped and jacked at the same time. Vkool ...
(Date:7/26/2014)... July 26, 2014 As the ... the true vision of Xoçai is ... its exclusive and healthy chocolate products. One such ... of cacao, açaí berries and blueberries, an ingredient ... high-antioxidant blend is utilized in all of Xoçai ...
(Date:7/25/2014)... Ireland (PRWEB) July 26, 2014 ... quality legal help to people who have suffered ... the launch of both their new company, and ... article on the new website explained, http://www.personalinjurysolicitorsireland.com/personal-injury-claims ... law. The focus of the company is always ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 In recent years, ... and eager to reverse the symptoms associated with age-related testosterone ... media at large, a new case study from ... benefits of testosterone therapy using bioidentical hormones. , The ... father from Seattle who found himself beginning to feel the ...
(Date:7/25/2014)... A federal judge has denied defense ... Pinnacle hip lawsuits ( http://www.depuypinnacle-lawsuit.com/ ) selected as ... go before a jury on September 1, 2014, Bernstein ... 18th, U.S. District Judge Ed Kinkeade of the Northern ... may proceed to trial against Johnson & Johnson, the ...
Breaking Medicine News(10 mins):Health News:Metabolic Enhancement Training Review Exposes Scott Abel's Program for Bodybuilding – Vkool.com 2Health News:Metabolic Enhancement Training Review Exposes Scott Abel's Program for Bodybuilding – Vkool.com 3Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 2Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 3Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 4Health News:PersonalInjurySolicitorsIreland.com Announces the Launch of their New Company and Website 2Health News:New Case Study Highlights Effectiveness of Testosterone Therapy in Fighting Weight Gain and Fatigue 2Health News:New Case Study Highlights Effectiveness of Testosterone Therapy in Fighting Weight Gain and Fatigue 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 2Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 4
... available at www.urac.org/bestpractices WASHINGTON, Feb. 13 ... Practices in Health Care Consumer Empowerment and Protection Conference ... In addition to Ian Morrison,s opening keynote address ... for Value for All Americans , and Lee Woodruff,s ...
... Medical Inc. (NYSE: SMA ), a leading independent ... other medical markets, announced today that Brian S. Moore, President ... President and Chief Financial Officer, are scheduled to present at ... Nevada, Las Vegas on Tuesday, February 24, 2009 at ...
... 13 Micromet, Inc. (Nasdaq: MITI ), today announced that ... Annual Orange County Growth Stock Conference at the Ritz-Carlton Laguna Niguel on ... Annual Orange County Growth Stock Conference, Date: ... Pacific Time, Place: The Ritz-Carlton Laguna Niguel, ...
... Feb. 13 /PRNewswire-Asia/ -- The Hong Kong Sanatorium ... team had,successfully performed a large number of cases ... the application of computer-assisted,navigation system since its first ... hospital in Hong Kong which has acquired the ...
... "number sense" appear to be part of the shared ... language to explain abstractions that apparently takes human math ... an assistant professor of psychology and neuroscience at Duke ... monkeys think about numbers without using language. She,s looking ...
... SAVANNAH, Ga., Feb. 13 Founders Club will donate $5 ... the Mammography Fund at St. Joseph,s/Candler. "The Mammography Fund ... crucial in the fight against cancer," Jeff Andrews, CEO of ... be sold at Edwin Watts Golf stores and specialty golf ...
Cached Medicine News:Health News:URAC Announces Agenda for 2009 Best Practices in Health Care Consumer Empowerment and Protection Conference 2Health News:URAC Announces Agenda for 2009 Best Practices in Health Care Consumer Empowerment and Protection Conference 3Health News:Micromet To Present at the ROTH 21st Annual Orange County Growth Stock Conference 2Health News:Micromet To Present at the ROTH 21st Annual Orange County Growth Stock Conference 3Health News:Micromet To Present at the ROTH 21st Annual Orange County Growth Stock Conference 4Health News:Navigation System Significantly Improves the Surgical Accuracy of Total Knee Replacement for Arthritis Patients 2Health News:Navigation System Significantly Improves the Surgical Accuracy of Total Knee Replacement for Arthritis Patients 3Health News:Navigation System Significantly Improves the Surgical Accuracy of Total Knee Replacement for Arthritis Patients 4Health News:Pre-verbal number sense common to monkeys, babies, college kids 2Health News:Founders Club Proudly Supports the St. Joseph's/Candler Mammography Fund 2
(Date:7/25/2014)... BERWYN, Pa. , July 25, 2014  AMETEK, ... appointment of Kurtis L. Goos as Vice ... Engineered Materials, Interconnects and Packaging (EMIP) Division. ... has extensive general management and business development experience, especially ... to make important contributions to the continued growth and ...
(Date:7/25/2014)... -- Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ) today ... second quarter 2014 financial results before the NASDAQ Global ... same day, Arena will host a conference call and ... Time). The conference call may be ... for international callers. Please specify to the operator that ...
(Date:7/24/2014)... 24, 2014  PTC Therapeutics, Inc. (NASDAQ: ... a webcast conference call to report its second quarter ... company,s business and outlook on Thursday, August 7, 2014 ... market. The call can be accessed ... five minutes prior to the start of the call ...
Breaking Medicine Technology:AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 3
Provide 1.5mm protection throughout. Six durable, attractive vinyl coverings are available. Lead glass window factory installed. Larger window available....
Height-Adjustable Mobile X-ray Barrier lets you get close to your patient during special procedures like cardiac cath. 24"H x 36"W viewing panel shields the upper body of one or two people and swivel...
RayShield Frame Mounted Overhead Lead Acrylic Barriers are offered in a choice of three sizes: 60 cm x 80 cm ( 24" x 32") wide, 60 cm x 50 cm( 24" x 20") wide. Lead acrylic windows of 0.5 mm and 1.0 ...
Protective Curtain for Barriers can be used on any of our RayShield® Barriers. Whether they are ordered with the barrier or as a retrofit, RayShield Protective Curtains are easy to install with s...
Medicine Products: