Navigation Links
Abnormal EKG can predict death in stroke patients

People who suffer an ischemic stroke and also have an abnormality in the heart's electrical cycle are at a higher risk of death within 90 days than people who do not have abnormal electrical activity at the time of emergency treatment, according to new research.

The study also provides a threshold at which the threat of death is highest: QTc intervals greater than 440 milliseconds in women and 438 milliseconds in men have the worst prognosis. The findings are published online March 20, 2009, in the Journal of Stroke and Cerebrovascular Diseases.

"From a clinical perspective, our study offers additional parameters to consider while treating stroke patients in the Emergency Department setting,' said corresponding author Latha G. Stead, M.D., professor and chair of the Department of Emergency Medicine at the University of Rochester Medical Center, who recently joined the URMC from the Mayo Clinic. "It appears that reviewing the medications a patient is taking and looking specifically for those that might prolong the QTc interval would be a useful practice."

The QTc interval is a measure of the electrical activity of the heart. An EKG records the waves of activity and its pattern, which is labeled with letters Q and T. Doctors look for the appropriate intervals between each letter, showing that the heart's electrical signals are steadily passing through the ventricles. A prolonged QTc interval means it takes too long for the electrical signal to pass.

Prolonged QTc intervals can be the result of a rare genetic disorder, medications, electrolyte imbalances, or congenital heart disease. Scientific data on the relationship between abnormal QTc intervals and death has been inconsistent, and few studies have looked at this relationship in the context of acute ischemic stroke, Stead said.

Researchers studied the medical records of 345 ischemic stroke patients at the Mayo Clinic, treated between 2001 and 2004, and followed for 90 days. Further analysis was done to see if the researchers could identify a QTc cutoff that would accurately predict death within 90 days.

About 35 percent of the patients had a prolonged QTc interval at the time of the emergency department visit. An estimated 81 percent of all patients were expected to survive the next three months. However, results showed that only 70.5 percent of the patients with a prolonged QTc interval survived compared with 87.1percent of the patients without a prolonged QTc interval.

In addition, researchers found that although the causes of death ranged from stroke to cardiac illnesses to cancer and respiratory failure, most patients died of stroke or cardiac causes. In those cases, about half of the patients had prolonged QTc intervals. Among the stroke survivors, patients with prolonged QT intervals had poorer functional outcomes.

About 795,000 Americans each year suffer a new or recurrent stroke. That means, on average, a stroke occurs every 40 seconds, according to the American Stroke Association. Ischemic strokes, obstructions of the blood vessels supplying blood to the brain, account for the majority of cases.

Stead is supported by the Mayo Foundation Emergency Medicine Career Research Career Development Award.


Contact: Leslie Orr
University of Rochester Medical Center

Related medicine news :

1. Brain abnormality found in boys with attention deficit hyperactivity disorder
2. Abnormal Heart Rhythm Boosts Death Risk for Diabetics
3. Risk Score May Predict Abnormal Heart Rhythm
4. New Drug Shows Promise Against Heartbeat Abnormality
5. Rhythm abnormality of unknown origin strongly predicts sudden death risk in heart disease patients
6. Abnormal Heart Function Reduces Exercise Capacity
7. Gene abnormality found to predict childhood leukemia relapse
8. Decreased activity of basal ganglia is the main cause of abnormal muscle constrictions in dystonia
9. Molecular Breast Imaging Performs Better Than Ultrasound in Patients With Mammographic Abnormalities
10. Novel imaging technique reveals brain abnormalities that may play key role in ADHD
11. Scans Reveal Brain Abnormalities in Fibromyalgia Patients
Post Your Comments:
(Date:11/27/2015)... Rosa, CA (PRWEB) , ... November 27, 2015 , ... ... Northern California Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at ... meeting. They observed that both STEMI and Sepsis conditions present in similar ways and ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... contact center software Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term ... fully supported Asterisk 11 LTS brings Q-Suite 5.10 up-to-date with a version of ...
(Date:11/26/2015)... NV (PRWEB) , ... November 26, 2015 , ... Inevitably ... strategy. Many customers choose to buy during the Black Friday and Cyber Monday ... Shoppers don’t need to search the Internet high and low to find the best ...
(Date:11/26/2015)... ... 2015 , ... Somu Sivaramakrishnan announced today that he joined ... offers travelers, value and care based Travel Services, including exclusive pricing on a ... cabin upgrades and special amenities such as, shore excursions, discounted fares, travel gifts ...
(Date:11/26/2015)... ... November 26, 2015 , ... Jobs in hospital medical laboratories ... and offered by healthcare staffing agency Aureus Medical Group . These ... October 2015 among those searching for healthcare jobs through the company’s website, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Marker Testing Market: Supplier Shares, Competitive ... offering.  --> ) ... "2016 Future Horizons and Growth Strategies ...
(Date:11/25/2015)... , Nov. 25, 2015  Linden Care, LLC, ... optimizing treatment outcomes for patients suffering from chronic pain, ... for a Temporary Restraining Order (TRO) enjoining Express Scripts ... two companies. --> --> ... all of its legal options. --> ...
(Date:11/25/2015)... Israel , November 25, 2015 ... KTOV ) (TASE: KTOV), a biopharmaceutical company focused ... treatment of various clinical conditions, today announced the closing ... American Depository Shares ( ADSs ), each representing 20 ... up to 3,158,900 ADSs. The ADSs and warrants were ...
Breaking Medicine Technology: